期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 46, 期 1, 页码 118-125出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/21691401.2017.1296850
关键词
Doxorubicin; niosome; magnetite nanoparticles; intraperitoneal chemotherapy; cytotoxicity
资金
- Kerman Neuroscience Research Center (KNRC) [85-32/4]
The current work deals with developing a suitable drug delivery system of doxorubicin (DOX) for intraperitoneal chemotherapy using niosomes through formulating non-ionic surfactants consisting of Brij (TM) 52, span (TM) 60 and Solulan (TM) C24. Entrapping the magnetite nanoparticles in the hydrophilic parts of niosomes was accompanied with high-efficient DOX loading by the current novel remote-loading method. Cytotoxicity of the prepared formulations was evaluated in vitro against A549 and PC-12 cell lines using the colorimetric WST-1 assay test. The obtained results revealed that, the cytotoxicity of DOX increased up to 22% especially on A549 cells by the current delivery system.
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