Article
Biotechnology & Applied Microbiology
N. Gonzalez-Ballesteros, N. Florez-Fernandez, M. D. Torres, H. Dominguez, M. C. Rodriguez-Arguelles
Summary: Crude fucoidans extracted from Sargassum muticum using hot water extraction were utilized in the synthesis of gold nanoparticles, with an optimization process to achieve homogeneous nanoparticles. A fucoidan fraction with higher sulfate content was obtained during extraction, containing additional beneficial components. The synthesized nanoparticles were thoroughly characterized to ensure their performance.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Pablo G. del Rio, Noelia Florez-Fernandez, Milena Alvarez-Vinas, Maria Dolores Torres, Aloia Romani, Herminia Dominguez, Gil Garrote
Summary: The study proposed a closed loop biorefinery employing sustainable technologies for the complete exploitation of invasive brown macroalgae Sargassum muticum. Sequential extraction methods were used to recover fucoidan efficiently and increase antioxidant capacity content. Additionally, ethanol and heat were produced from the resulting spent solid, verifying the cascade biorefinery as an appropriate strategy for the valorization of Sargassum muticum.
Article
Environmental Sciences
Valeria Acevedo-Garcia, Noelia Florez-Fernandez, Marta Lopez-Garcia, Jose Manuel Lopez Vilarino, Herminia Dominguez, Maria Dolores Torres
Summary: The brown seaweed Sargassum muticum can be processed to extract fucoidan through non isothermal autohydrolysis, with acetone precipitation used for recovery of fucose-containing oligosaccharides in the hydrolyzates. The acetone:hydrolyzate volume ratio affects both the yields and composition of the precipitated fractions. The precipitated fractions with different acetone volumes exhibit varying levels of phenolic and sulfate content, antiradical activity, and slight cytotoxic activity against human colon adenocarcinoma cells.
WASTE AND BIOMASS VALORIZATION
(2021)
Article
Engineering, Environmental
Noelia Florez-Fernandez, Marta Illera, Marta Sanchez, Pablo Lodeiro, Maria Dolores Torres, Maria Elvira Lopez-Mosquera, Manuel Soto, Manuel Sastre de Vicente, Herminia Dominguez
Summary: This study investigates a novel biorefinery scheme for comprehensive valorization of Sargassum muticum by producing a Sap fraction with plant biostimulant potential through initial pressing and subsequent autohydrolysis treatment, high-yield biogas, and the possibility of preparing adsorbents from waste solids.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Agricultural Engineering
Igor N. Caxiano, Pedro A. Mello, Pedro H. R. Alijo, Leonardo V. Teixeira, Rodrigo F. Cano, Jeiveison G. S. S. Maia, Joao B. V. Bastos, Mauro S. G. Pava
Summary: This study evaluates the scale effects in designing a biorefinery from Sargassum muticum seaweed by conducting detailed process modeling. The results show that there are differences in capital expenditures and product selling prices between the two projects.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Roza V. Usoltseva, Anastasiya O. Zueva, Olesya S. Malyarenko, Stanislav D. Anastyuk, Olga P. Moiseenko, Vladimir V. Isakov, Mikhail I. Kusaykin, Airong Jia, Svetlana P. Ermakova
Summary: This study reports the structure of fucoidan from Sargassum miticum and its enhanced inhibitory effect on the colony formation of cancer cells when used in combination with a glycolysis inhibitor.
Article
Biotechnology & Applied Microbiology
Uraipan Saetan, Panwira Nontasak, Kunwadee Palasin, Hirun Saelim, Monwadee Wonglapsuwan, Jaruwan Mayakun, Supattra Pongparadon, Wilaiwan Chotigeat
Summary: Fucoidan extracted from Sargassum plagiophyllum and Sargassum polycystum in southern Thailand showed antioxidant properties, inhibited TNF-alpha production, and had inhibitory effects on breast cancer cells. Further research is needed to explore the potential health benefits of these fucoidans.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Wang, Yong Ri Cui, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: This study evaluated the anti-inflammatory effects of SFF-PS-F5 fucoidan extracted from fermented Sargassum fusiforme. The results from in vitro and in vivo experiments demonstrate that SFF-PS-F5 effectively inhibits inflammatory responses, suggesting its potential as a functional ingredient in the food and cosmetic industries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Xue Liu, Xin Liu, Mikhail Kusaykin, Miansong Zhang, Xinfeng Bai, Tingting Cui, Yaping Shi, Changheng Liu, Airong Jia
Summary: In this study, four different fucoidans were obtained from different types of seaweed and used to prepare chitosan/fucoidan nanoparticles. It was found that SFP and SHP exhibited strong binding abilities to P-selectin and EGFR. Further analysis revealed that SFP mainly consisted of galactose and fucose, with sulfated branches.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Chemical
Chih-Yu Huang, Chien-Yen Huang, Chao-Chun Yang, Tse-Min Lee, Jo-Shu Chang
Summary: The study investigated the effects of fucoidans extracted from Sargassum glaucescens on promoting human hair growth, finding that fucoidans with a molecular weight higher than 1 kDa demonstrated hair growth-promoting ability, especially oligo-fucoidans. The effects of fucoidans on HFPDC proliferation were correlated with gene expressions of IGF-1 and LEF-1, and hair growth-promoting activity was observed in mice models after treatment with Sargassum glaucescens fucoidan extracts, indicating the potential of fucoidan as a topical medicine for alopecia treatment.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Food Science & Technology
Ji-Eun Lee, Xiaotong Xu, So-Mi Jeong, Woo-Sin Kang, Si-Hyeong Ryu, Han-Ho Kim, Su-Ryong Kim, Ga-Hye Lee, Min-Ji Kim, Dong-Hyun Ahn
Summary: This study found that using crude enzymes from S. oneidensis PKA 1008 can enhance the polysaccharide degradation of SM and produce oligosaccharides with anti-inflammatory effects.
FOOD SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xiang Li, Shijun Xin, Xiaoqun Zheng, Liqin Lou, Shiqing Ye, Shengkai Li, Qilong Wu, Qingyong Ding, Ling Ji, Chunrong Nan, Yongliang Lou
Summary: Fucoidan has inhibitory effects on cancer development and anti-inflammatory properties. This study showed that fucoidan can reverse inflammation in human colonic epithelial cells and confirmed its anti-inflammatory effect in mice experiments. Fucoidan can inhibit cell proliferation and promote apoptosis in colorectal cancer cells, and block the cell cycle. In an inflammation-related colorectal cancer animal model, fucoidan intervention significantly reduced the tumor incidence and decreased the expression levels of inflammatory factors.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Rui Li, Qing-Ling Zhou, Shu-Tong Chen, Min-Rui Tai, Hong-Ying Cai, Rui Ding, Xiao-Fei Liu, Jian-Ping Chen, Lian-Xiang Luo, Sai-Yi Zhong
Summary: In this study, a fucoidan polysaccharide (SHF) was extracted from Sargassum hemiphyllum collected in the South China Sea. The SHF, with a molecular weight of 1166.48 kDa, consisted of glucose, galactose, fucose, xylose, mannose, and three uronic acids. The SHF exhibited excellent immunostimulatory activity, increasing NO secretion in macrophage cells via upregulation of COX-2 and iNOS levels.
Article
Construction & Building Technology
Houssam Affan, Karim Touati, Mohammed-Hichem Benzaama, Daniel Chateigner, Yassine El Mendili
Summary: Stranded seaweed poses a serious threat to coastal areas when the tide recedes. This study investigated the potential use of Sargassum mitucum seaweed fiber in building construction. The results showed that a cob made with Sargassum muticum algae exhibited better thermal and hygroscopic properties compared to a cob made with flax fiber. The study also highlighted the global issue of sargassum algae expansion and suggested that utilizing stranded algae could improve the mechanical and hygrothermal performance of cob-based materials.
Article
Biochemistry & Molecular Biology
Lei Wang, Yong Ri Cui, Hyo-Geon Lee, Xiaoting Fu, Kaiqiang Wang, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: The study isolated a fucoidan (SFF-PS-F5) from fermented Sargassum fusiforme and investigated its antioxidant activity in vitro and in vivo. SFF-PS-F5 showed potent antioxidant effects by scavenging ROS and up-regulating intracellular antioxidants, protecting cells from damage and improving survival rate in zebrafish. This makes it a potential ingredient in pharmaceutical, nutraceutical, and cosmeceutical industries.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agricultural Engineering
Blanca E. Morales-Contreras, Noelia Florez-Fernandez, M. Dolores Torres, Herminia Dominguez, Rosa M. Rodriguez-Jasso, Hector A. Ruiz
Summary: This review highlights the importance and application of hydrothermal systems as an innovative technology for fractionation of macroalgae, aiming to recover profitable products. Hydrothermal treatments are considered a promising alternative for obtaining high value-added compounds from this biomass, providing great versatility in terms of operational conditions.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
J. Andre, N. Florez-Fernandez, H. Dominguez, M. D. Torres
Summary: Microwave-assisted hydrothermal processing is used to recover valuable compounds with antioxidant and gelling properties from Ulva spp. green seaweed. The extraction conditions were studied to achieve a comprehensive utilization of the seaweed. Selective coagulation of ulvan stimulated by a bio-ionic liquid was emphasized during the extraction process. The microwave treatment had a significant impact on the phytochemical properties of the soluble extracts, with the highest sulfate and protein content at 160 degrees C and the highest antioxidant features at 200 degrees C. The ulvan extracted at 160 degrees C showed the highest yields, molecular weight, and strongest gel features.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biotechnology & Applied Microbiology
K. Baltrusch, N. Florez-Fernandez, M. Illera, M. D. Torres, M. E. Lopez-Mosquera, H. Dominguez
Summary: Seaweed derived biostimulants are gaining attention as an important tool in sustainable agriculture. This research explores the biostimulant potential of the solubles obtained from Sargassum muticum biomass through green extraction technologies. Different drying techniques were compared and low stress drying techniques showed better conservation of bioactive compounds and biostimulant potential.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Chemistry, Medicinal
Milena Alvarez-Vinas, Sandra Rivas, Maria Dolores Torres, Herminia Dominguez
Summary: The development of greener processes for the sustainable utilization of raw materials is increasingly demanded for environmental and economic reasons. A rapid and chemical-free technique for the extraction of hybrid kappa/iota (6/4) carrageenan from Sarcopeltis (ex Gigartina) skottsbergii was proposed. The extracted carrageenans showed suitable rheological properties for commercial uses, and the microwave-assisted hydrothermal treatment was found to be an efficient tool for carrageenan extraction without the need for chemicals.
Article
Biotechnology & Applied Microbiology
Lucia Lopez-Hortas, Noelia Florez-Fernandez, Jose Mazon, Herminia Dominguez, Maria Dolores Torres
Summary: The present study focuses on the dehydration of Rugulopteryx okamurae seaweed using conventional and innovative techniques. The optimized microwave hydrodiffusion and gravity (MHG) treatment resulted in fast and efficient drying, with recovery of antioxidant and gelling fractions. The results showed that MHG treatment reduced processing time significantly and provided higher yields and antioxidant potential compared to conventional drying methods. The MHG liquid phases exhibited similar structural profiles to commercial alginates and alginate-based hydrogels with improved viscoelastic properties were successfully prepared.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Chemistry, Medicinal
Noelia Florez-Fernandez, Jorge F. Pontes, Filipa Guerreiro, Ines T. Afonso, Giovanna Lollo, Maria Dolores Torres, Herminia Dominguez, Ana M. Rosa da Costa, Ana Grenha
Summary: The composition of seaweeds is complex, including vitamins, phenolic compounds, minerals, and polysaccharides. Fucoidan, the main polysaccharide in brown seaweeds, has various biological activities. Chitosan, another marine biopolymer, is popular in the biomedical field. This study evaluated the ability of fucoidan to produce nanoparticles with chitosan as a counterion. The nanoparticles obtained were negatively charged and had a size of 200-300 nm. The IC50 of fucoidan increased when tested in nanoparticle form, indicating their potential for biomedical applications.
Article
Chemistry, Medicinal
Tania Ferreira-Anta, Noelia Florez-Fernandez, Maria Dolores Torres, Jose Mazon, Herminia Dominguez
Summary: A scheme for Rugulopteryx okamurae biomass valorization based on a green, rapid and efficient fractionation technique was proposed. Microwave-assisted pressurized hot water extraction was used to solubilize different seaweed components. The extraction performance and bioactive properties of the soluble extracts were enhanced by operation time. The solid residue showed potential for preparation of biomaterials according to its rheological properties.
Review
Pharmacology & Pharmacy
Noelia Florez-Fernandez, Carlos Vaamonde-Garcia, Maria Dolores Torres, Manuela Bujan, Alexandra Muinos, Antonio Muinos, Maria J. Lamas-Vazquez, Rosa Meijide-Failde, Francisco J. Blanco, Herminia Dominguez
Summary: The anti-inflammatory properties of fucoidans have been well studied in vitro and in some in vivo experiments. In addition to this activity, the lack of toxicity and the possibility of obtaining fucoidans from a widely available and renewable source make them attractive as novel bioactives. However, the heterogeneity and variability in composition, structure, and properties of fucoidans, depending on factors such as seaweed species and extraction methods, pose challenges for standardization.
Article
Food Science & Technology
Tania Ferreira-Anta, Maria Dolores Torres, Herminia Dominguez, Noelia Florez-Fernandez
Summary: Seaweeds contain various bioactive compounds of interest to the food industry, such as phenolic compounds, polysaccharides, proteins, and vitamins. Green extraction technologies, such as pressurized hot water extraction, were used to obtain these compounds. The study found that the highest fucoidan content was recovered at 160°C, while the maximum phloroglucinol content and antioxidant activity were achieved at 220°C. Encapsulation of these bioactive fractions using mannitol was also investigated.
Article
Plant Sciences
Guido Domingo, Milena Marsoni, Milena Alvarez-Vinas, M. Dolores Torres, Herminia Dominguez, Candida Vannini
Summary: The application of seaweed extract-based biostimulants shows promise in achieving sustainable agriculture by improving crop yield and mitigating the effects of climate change. In this study, a protein hydrolysate-rich C. crispus extract was tested on tomato plants and found to promote plant growth and enhance drought tolerance.
Article
Food Science & Technology
Tania Ferreira-Anta, Maria Dolores Torres, Jose Manuel Vilarino, Herminia Dominguez, Noelia Florez-Fernandez
Summary: Polymeric microparticles encapsulating bioactive compounds from two hop varieties were successfully formulated using green extraction processes. The microparticles exhibited suitable yield, morphological, and viscosity properties for potential applications in the food and non-food industries.
Article
Biotechnology & Applied Microbiology
Sung-Yeoul Kim, Vikash Chandra Roy, Jin-Seok Park, Byung-Soo Chun
Summary: This study aims to extract functional substances from Undaria pinnatiida sporophyll using supercritical carbon dioxide (SC-CO2) and subcritical water extraction (SWE). The results showed that the consecutive green extraction method can yield extracts rich in fucoxanthin and beta-carotene, and the sporophyll of Undaria pinnatiida contains health-beneficial fatty acids. Additionally, SWE can extract substances with antioxidant, antibacterial, and antihypertensive activities.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2024)
