Article
Medicine, Research & Experimental
Mamdooh Ghoneum, Mai Alaa El-Dein, Nariman K. Badr El-Din
Summary: In this study, the anticancer effect of Marina Crystal Minerals (MCM) was evaluated in mice with mammary adenocarcinoma cells. MCM treatment reduced tumor volume, induced cancer cell apoptosis, and arrested cell cycle progression. It also activated the immune system and enhanced natural killer (NK) cell cytotoxicity. These findings suggest that MCM has chemopreventive potential and could be beneficial for treating breast adenocarcinoma.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Medicinal
Nahed Saleh, Tamer Allam, Reda M. S. Korany, Abdelfattah M. Abdelfattah, Ahmed M. Omran, Mabrouk Attia Abd Eldaim, Aziza M. Hassan, Nermeen Borai El-Borai
Summary: This study evaluates the antitumor efficacy of hesperidin (Hesp) versus cisplatin (Cis) in Ehrlich ascites carcinoma (EAC)-bearing mice, as well as its protective effect against Cis-triggered nephrotoxicity. The study found that hesperidin can alleviate the renal adverse side effects of cisplatin and has potential antitumor effects.
Article
Biochemistry & Molecular Biology
Sadiya Khwaja, Kaneez Fatima, Divya Mishra, Vineet Babu, Yogesh Kumar, Sumera Banu Malik, Misbah Tabassum, Suaib Luqman, Dnyaneshwar U. Bawankule, Debabrata Chanda, Feroz Khan, Dilip M. Mondhe, Arvind S. Negi
Summary: This study focused on the total synthesis of indanocine and its analogues, which showed potential anticancer and anti-inflammatory activities. Benzylindanocine 12i exhibited microtubule destabilization and anti-inflammatory effects, reducing EAC tumor in mice and showing safety in rodent studies. The concurrent anticancer and anti-inflammatory activities of benzylindanocine suggest further optimization for better efficacy and druggability.
CHEMICAL BIOLOGY & DRUG DESIGN
(2021)
Article
Biochemistry & Molecular Biology
Fekria Tayel, Magdy E. Mahfouz, Afrah F. Salama, Mohammed A. Mansour
Summary: In this study, ethoxyquin (EQ) was used as a novel LDH inhibitor to target cancer cells and improve the therapeutic efficacy of cisplatin (CIS) in murine Ehrlich ascites carcinoma (EAC). EQ demonstrated significant anti-tumor effects on EAC, including decreased expression of the anti-apoptotic gene Bcl-2, increased expression of apoptotic genes (BAX and caspase-3), and reduced autophagic activity. Co-administration of EQ and CIS showed the highest anti-tumor effect against EAC, suggesting EQ as a potential combinatory drug to enhance cisplatin efficacy.
Article
Chemistry, Medicinal
Kaneez Fatima, Zahoor Ahmad Wani, Abha Meena, Suaib Luqman
Summary: Geraniol, a acyclic monoterpene found in plant essential oils, has shown potent antiproliferative and antitumor effects through its antiinflammatory and antioxidant properties. Molecular and cell-based assays revealed its ability to inhibit cancer cell proliferation, affect gene expression, and interact with molecular targets. In animal models, geraniol demonstrated tumor growth inhibition and displayed safety at certain concentrations, suggesting its potential as a novel anticancer agent.
PHYTOTHERAPY RESEARCH
(2021)
Article
Plant Sciences
Faten M. Ibrahim, Abeer Y. Ibrahim, Samah A. El-Newary, Saber F. Hendawy, Mohamad F. Mahomoodally
Summary: The aqueous-alcoholic crude extract and fractions of Vitex agnus-castus showed significant antioxidant and anti-inflammatory properties in vitro, with potential anti-tumor effects.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Biotechnology & Applied Microbiology
Mohamed M. El-Zahed, Zakaria A. Baka, Mohamed I. Abou-Dobara, Ahmed K. El-Sayed, Magy M. Aboser, Ayman Hyder
Summary: A novel biosynthesis method of dual reduced graphene oxide/silver nanocomposites using Escherichia coli D8 (MF06257) strain metabolite and sunlight was introduced in this work. Physicochemical analysis revealed sheet-like structures with spherically shaped silver nanoparticles and an average size of 8-17 nm. The nanocomposites showed uptake by the kidney and liver, causing moderate toxicity and exhibiting antitumor effects in cancer therapy.
BIORESOURCES AND BIOPROCESSING
(2021)
Article
Biochemistry & Molecular Biology
Irina S. Trukhan, Denis N. Tomilin, Nataliya N. Dremina, Lyubov N. Sobenina, Michael G. Shurygin, Konstantin B. Petrushenko, Igor K. Petrushenko, Boris A. Trofimov, Irina A. Shurygina
Summary: A bright far-red emitting unsymmetrical meso-CF3-BODIPY fluorescent dye was synthesized and studied as a lysosome-specific fluorescent dye in Ehrlich carcinoma cells.
Article
Environmental Sciences
Mabrouk Attia Abd Eldaim, Ehab Tousson, Ibrahim El Tantawy El Sayed, Asmaa Zakaria Abd Elmaksoud, Abdullah A. S. Ahmed
Summary: The study investigated the protective potential of a newly synthesized 9-diaminoacridine derivative (9-DAAD) against Ehrlich ascites carcinoma (EAC) induced hepatorenal injury in female mice. The results showed that treatment with 9-DAAD improved liver and kidney structures, functions, modulated EAC altered parameters, and reduced hepatic and renal cells proliferation and DNA synthesis, indicating the potential ameliorative effect of 9-DAAD against EAC-induced hepatorenal injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Plant Sciences
Sreena Raj, Rama Jayaraj, Gothandam Kodiveri Muthukaliannan
Summary: Amorphophallus commutatus var. wayanadensis (ACW) exhibits significant antioxidant and anticancer activities, suggesting its potential as a preventive and supportive therapy for emerging tumors.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Priyanka P. Patil, Pukar Khanal, Vishal S. Patil, Rajitha Charla, Darasaguppe R. Harish, Basanagouda M. Patil, Subarna Roy
Summary: The present study found that cocoa bean extract had a protective effect against doxorubicin-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity, and exhibited potent antioxidant and anticancer activities.
Article
Biochemistry & Molecular Biology
Venugopal R. Bovilla, Mahadevaswamy G. Kuruburu, Vidya G. Bettada, Jayashree Krishnamurthy, Olga A. Sukocheva, Rajesh K. Thimmulappa, Nanjunda Swamy Shivananju, Janardhan P. Balakrishna, SubbaRao Madhunapantula
Summary: The study investigated the expression of Nrf2 in breast cancer tissues and cell lines, finding that silencing or inhibiting Nrf2 could reduce cancer cell proliferation and migration, induce cell cycle arrest and activate apoptosis, as well as sensitize breast cancer cells to cisplatin. Additionally, experimental mouse models showed that pharmacological Nrf2 inhibitor brusatol slowed tumor growth and activated anti-cancer effects in the tumor microenvironment. Further testing is needed to confirm the potential of Nrf2 as a marker and therapeutic target for chemo sensitization in drug resistant and advanced tumors.
Article
Chemistry, Physical
Olga Mikolaichuk, Elena A. Popova, Alexandra Protas, Ilnaz T. Rakipov, Dmitry A. Nerukh, Andrey Petrov, Nikolay A. Charykov, Sergei Ageev, Grigorii Tochilnikov, Iulia G. Zmitrichenko, Aleksandr N. Stukov, Konstantin N. Semenov, Vladimir V. Sharoyko
Summary: This study presents a comprehensive investigation of a water-soluble substance from the class of triazine derivatives alkylating agents, including physicochemical properties, biological activity, and computational modeling.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Medicine, Research & Experimental
Mamdouh A. Oraby, Ola Elazazy, Heba M. Karam, Doaa S. Fadaly, Ayman A. Ibrahim
Summary: This study suggests that MitoQ combated tumor cell survival and progression in EAC mice by maintaining mtROS and restoring mitophagy, thereby attenuation of NF-icB activation.
Article
Chemistry, Medicinal
Sameh S. Elhady, Eman S. Habib, Reda F. A. Abdelhameed, Marwa S. Goda, Reem M. Hazem, Eman T. Mehanna, Mohamed A. Helal, Khaled M. Hosny, Reem M. Diri, Hashim A. Hassanean, Amany K. Ibrahim, Enas E. Eltamany, Usama Ramadan Abdelmohsen, Safwat A. Ahmed
Summary: This study reports the cytotoxic, apoptotic, and antiangiogenic effects of ceramides isolated from the Red Sea algae Hypnea musciformis in an experimental model of Ehrlich ascites carcinoma (EAC).
Article
Gastroenterology & Hepatology
Arjun Singh, Jagmohan Singh, Satish Rattan
Summary: Background data on the neuromodulatory effects of brain-derived neurotrophic factor (BDNF) in the gastrointestinal tract have been reported, but there is still a lack of data on the presence, distribution, and release of BDNF in the gastrointestinal tract, including the internal anal sphincter (IAS). The study found that BDNF/TrkB is present not only in the enteric nervous system (ENS), but also in the smooth muscle cells (SMCs). BDNF is released locally from the ENS (myenteric and submucosal plexus) and the SMCs, which has implications for IAS-related rectoanal motility disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Biochemistry & Molecular Biology
Mubashir Mintoo, Sameer Khan, Abubakar Wani, Sumera Malik, Deendyal Bhurta, Sandip Bharate, Fayaz Malik, Dilip Mondhe
Summary: The study reveals that IIIM-290 induces apoptosis in MOLT-4 cells by upregulating various apoptotic proteins, and shows promising anticancer potential in murine leukemic tumor models.
MOLECULAR CARCINOGENESIS
(2021)
Article
Pharmacology & Pharmacy
Pankaj Yadav, Hina Iqbal, Kapil Kumar, Parmanand Kumar, Divya Mishra, Arjun Singh, Anirban Pal, Pradipto Mukhopadhyay, Beena Vamadevan, Dhirendra Singh, Arvind Singh Negi, Debabrata Chanda
Summary: LT-9 exhibited potent biological activity against sepsis in CLP mice by reversing vascular hyporeactivity and enhancing contraction response to norepinephrine through opening of L-type VDCC. Oral administration of LT-9 for 15 days significantly improved survival time, hemodynamic and ECG profile in CLP mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Akanksha Behl, Parul Sarwalia, Sushil Kumar, Chittaranjan Behera, Mubashir Javed Mintoo, Tirtha Kumar Datta, Prem N. Gupta, Anil K. Chhillar
Summary: The synergistic potential of MUC1 inhibitors and Gemcitabine-loaded nanoparticles was discussed in this study, aiming to enhance the therapeutic efficacy. Gemcitabine and MUC1 inhibitors were loaded into polymeric nanoparticles using the double emulsion solvent evaporation method. The results showed that the twin-loaded nanoparticles exhibited better anticancer effects.
MOLECULAR PHARMACEUTICS
(2022)
Article
Multidisciplinary Sciences
Sameer Ullah Khan, Anup Singh Pathania, Abubakar Wani, Kaneez Fatima, Mubashir Javed Mintoo, Baseerat Hamza, Masroor Ahmad Paddar, Wadhwa Bhumika, Loveleena Kour Anand, Mir Shahid Maqbool, Sameer Ahmad Mir, Jaspreet Kour, Vunnam Venkateswarlu, Dilip Manikrao Mondhe, Sanghapal D. Sawant, Fayaz Malik
Summary: Lysosomal biogenesis plays a vital role in determining cell fate, but excessive biogenesis can lead to cell death. In pancreatic cancer cells, dysregulation of apoptosis allows the cells to evade cell death. However, a study has shown that treatment with SDS-203 triggers non-apoptotic cell death by causing an overaccumulation of lysosomes. This finding suggests that targeting lysosomal biogenesis could be a potential therapeutic approach for pancreatic cancer.
SCIENTIFIC REPORTS
(2022)
Correction
Multidisciplinary Sciences
Sameer Ullah Khan, Anup Singh Pathania, Abubakar Wani, Kaneez Fatima, Mubashir Javed Mintoo, Baseerat Hamza, Masroor Ahmad Paddar, Wadhwa Bhumika, Loveleena Kour Anand, Mir Shahid Maqbool, Sameer Ahmad Mir, Jaspreet Kour, Vunnam Venkateswarlu, Dilip Manikrao Mondhe, Sanghapal D. Sawant, Fayaz Malik
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Alok Tripathi, Aijaz A. John, Deepak Kumar, Saurabh Kumar Kaushal, Devendra Pratap Singh, Nazim Husain, Jayanta Sarkar, Divya Singh
Summary: This study reports the functional role of miR-539-3p in osteoblast functions and its downstream Akap-3 signaling in the regulation of osteoblastogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Integrative & Complementary Medicine
Sumera Malik, Mubashir J. Mintoo, Chilakala Nagarjuna Reddy, Rajesh Kumar, Pankul Kotwal, Sandip B. Bharate, Utpal Nandi, Dilip M. Mondhe, Sanket K. Shukla
Summary: The study evaluated new colchicine analogs for their anticancer activity and determined their mechanism of action and in vivo efficacy. IIIM-067 showed potent cytotoxicity and better selectivity than other analogs. It reduced clonogenicity and induced apoptosis in A549 cells, as well as showed promising anticancer activity in vivo.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Cell Biology
Mayank Maheshwari, Nisha Yadav, Mohammad Hasanain, Praveen Pandey, Rohit Sahai, Kuldeep Choyal, Akhilesh Singh, Mushtaq A. Nengroo, Krishan K. Saini, Deepak Kumar, Kalyan Mitra, Dipak Datta, Jayanta Sarkar
Summary: The article discusses the dual function of p21 in cancer, with both inhibitory and oncogenic effects. Specifically, p21 negatively regulates basal autophagy and has oncogenic activity during early tumor development, while its inhibition promotes survival and growth of established tumors.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Aram Ko, Mohammad Hasanain, Young Taek Oh, Fulvio D'Angelo, Danika Sommer, Brulinda Frangaj, Suzanne Tran, Franck Bielle, Bianca Pollo, Rosina Paterra, Karima Mokhtari, Rajesh Kumar Soni, Matthieu Peyre, Marica Eoli, Laura Papi, Michel Kalamarides, Marc Sanson, Antonio Iavarone, Anna Lasorella
Summary: LZTR1 is a substrate-specific adaptor of a CUL3-dependent ubiquitin ligase frequently mutated in cancer. The study identified EGFR and AXL as LZTR1 substrates targeted for degradation, and found that LZTR1 mutations result in the accumulation and deregulated signaling of EGFR and AXL. The study also revealed vulnerabilities of LZTR1-mutant tumors to inhibition of EGFR and AXL, providing precision targeting for patients with LZTR1-mutant cancer.
Article
Oncology
Simona Migliozzi, Young Taek Oh, Mohammad Hasanain, Luciano Garofano, Fulvio D'Angelo, Ryan D. Najac, Alberto Picca, Franck Bielle, Anna Luisa Di Stefano, Julie Lerond, Jann N. Sarkaria, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Summary: Proteogenomic characterization of human tumors has identified master kinases that play key roles in functional subtypes of glioblastoma. These master kinases have potential as subtype-specific therapeutic targets and can be used to inform patient selection in clinical trials. The researchers have also developed a classification tool that evaluates therapeutic response and subtype association in glioblastoma.
Article
Agricultural Engineering
Pooja Gaur, Feroz Khan, Karuna Shanker
Summary: This study successfully isolated biologically active compounds from Andrographis paniculata root that have the ability to absorb dietary fat, making them potential candidates for obesity management. 7-O-methyl-dihydro wogonin (MDHW) exhibited the strongest pancreatic lipase inhibition activity and showed a synergistic effect with orlistat. MDHW acts as a competitive inhibitor through energy transfer from pancreatic lipase, and the binding interaction between MDHW and pancreatic lipase is hydrophobic. In vitro and in silico studies confirmed the potential of MDHW as an anti-obesity agent for pharmaceutical and food industry applications.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Analytical
Pooja Gaur, Princi Gupta, Neerja Tiwari, Namita Gupta, Karuna Shanker
Summary: A novel HPTLC method was developed for the simultaneous quantification of six bioactive alkaloids in agro-waste of Piper longum. The method demonstrated excellent separation and specificity, and was successfully applied for accurate quantification in Piper longum roots. Additionally, the method was found to be environmentally friendly and energy efficient.
MICROCHEMICAL JOURNAL
(2023)
Article
Agriculture, Multidisciplinary
Pooja Gaur, Neerja Tiwari, Karuna Shanker
Summary: This study demonstrates the potential of using agricultural wastes of Piper longum as antiobesity agents through the extraction of pseudoalkaloids. One of the compounds, pellitorine, showed strong pancreatic lipase inhibitory activity and exhibited synergistic effects with orlistat. The structural compactness of the interaction between pellitorine and pancreatic lipase was confirmed by Fourier transform infrared spectral studies. Molecular docking studies further revealed the binding interaction between pellitorine and the catalytic active amino side residue of the protein. These findings suggest that pellitorine has the potential to be developed as an anti-obesity supplement.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
