Article
Chemistry, Analytical
Kai Jiang, Zhifeng Guan, Yifan Wang, Jiamin Sun, Weiwei Xiong, Fenfen Zheng, Yemei Wang, Jun-Jie Zhu
Summary: In this study, a new nanoplatform with targeting ability, imaging function, and photothermal/photodynamic therapy was developed. This nanoplatform, composed of cancer cell-derived carbon nanodots, exhibited wide light absorption and emission characteristics, as well as excellent biocompatibility and targeted ability. Under laser irradiation, the nanoplatform also demonstrated significant photothermal and photodynamic effects, showing great potential for cancer treatment.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Siming Ren, Mingjun Cui, Xinyu Chen, Shixiang Mei, Yujie Qiang
Summary: Carbon steel is widely used in various industries, and its corrosion is a major concern. Carbon dots (CDs), especially heteroatom-doped CDs, have been developed as green corrosion inhibitors. A study compared the corrosion inhibition efficiency and mechanisms of nitrogen-doped and nitrogen, sulfur codoped CDs. The results showed that both types of CDs can effectively restrain the corrosion of carbon steel, with the codoped CDs exhibiting higher inhibition performance. Molecular dynamics simulation revealed the strong interaction between the codoped CDs and the carbon steel substrate, which contributes to the superior corrosion inhibition.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Gwajeong Jeong, Taewook Kim, Seong Dae Park, Myong Jae Yoo, Chan Ho Park, Hyunseung Yang
Summary: This study develops organic gel sensors based on NS-CDs that display color changes in response to different solvents, offering strong solvatochromic performance and reusability, providing valuable insights for designing real-time organic solvent sensing platforms.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Spectroscopy
Linlin Wang, Jayasmita Jana, Jin Suk Chung, Won Mook Choi, Seung Hyun Hur
Summary: Low-cost nitrogen and boron-doped carbon nanodots (CPAP-CDs) with high quantum yield were synthesized through a facile hydrothermal treatment. These CPAP-CDs showed wide absorption, strong fluorescence, and pH-dependent behavior, making them suitable for detecting nitrite ions. The method had a low detection limit, wide linear detection range, and was successfully applied to different water samples testing.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Applied
Pengyuan Yin, Guixiang Yao, Tianru Zou, Nan A, Pei Na, Wenrong Yang, Hongbin Wang, Wei Tan
Summary: In this study, citric acid and glutathione were used as raw materials to prepare nitrogen and sulfur co-doped carbon dots via microwave heating. The obtained carbon dots exhibited stable blue luminescence and could be quenched by silver nanoparticles and recovered by mercury ions, which facilitated the construction of a highly sensitive fluorescent probe for detecting trace Hg2+.
Article
Chemistry, Physical
Shuo Li, Zheng Luo, Hanyu Tu, Hao Zhang, Weina Deng, Guoqiang Zou, Hongshuai Hou, Xiaobo Ji
Summary: The use of nitrogen and sulfur-codoped carbon dots (N,S-CDs) as electrolyte additives to guide homogeneous lithium ion deposition has been proposed to improve the stability and cycling life of lithium metal batteries.
ENERGY STORAGE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Wenge Zhang, Suqin Deng, Chao Yan, Zifan Zhu, Peiying Li, Nian Li, Yufang Chen, Tao Jin
Summary: This work demonstrates the preparation of (N, S)-co-doped fluorescent carbon dots (N, S-CDs) for mercury ions (Hg2+) detection. The resulting N, S-CDs exhibited excellent specificity and selectivity towards Hg2+ and could distinguish them from 26 anions and cations. The sensor demonstrated high-intensity fluorescence quenching at around 457 nm under the presence of Hg2+ and could detect Hg2+ in the 0.05-0.5 μM range with a 9.37 nM detection limit.
Article
Nanoscience & Nanotechnology
Shenna Chen, Yunping Hao, Ronghui Li, Yanxu Liu, Jinxia Li, Lina Geng
Summary: Recently, nitrogen-doped carbon dots (N-CDs) with high fluorescence intensity were synthesized and characterized. These N-CDs showed remarkable fluorescence properties and photostability, making them suitable for the detection of Hg2+ and glutathione (GSH). Furthermore, the N-CDs exhibited pH-sensitive behavior and could also be used for H+ detection. The outstanding performance of N-CDs suggests their potential applications in ecological pollution and biomolecule visualization monitoring.
Article
Environmental Sciences
Wei Wang, Shaoqing Li, Pengyuan Yin, Jiaxiong Li, Yi Tang, Min Yang
Summary: In this study, N, S-codoped fluorescent carbon dots were rapidly fabricated and used for the detection of tetracyclines. The synthesis parameters were optimized using response surface methodology, and the as-synthesized NSCDs exhibited superior photoluminescence stability and high quantum yield. The fluorescence intensity of the NSCDs could be effectively quenched by tetracyclines through the inner filter effect and photoinduced electron transfer.
Article
Nanoscience & Nanotechnology
Xiaoyan Wang, Jialuo Yu, Wan Ji, Maryam Arabi, Longwen Fu, Bowei Li, Lingxin Chen
Summary: A highly sensitive and selective chemosensing strategy for MC-LR determination was developed using nitrogen/phosphorus-codoped carbon dots. The fluorescence intensity of the carbon dots was quenched by Fe3+ and recovered quickly in the presence of MC-LR. The sensor showed promising applicability for MC-LR determination in complex environmental water samples, with benefits including simple operation, low cost, fast response time, selectivity, and sensitivity.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Analytical
Yujie Shen, Mingcong Rong, Xiaodan Qu, Bolin Zhao, Jinhui Zou, Zhenbang Liu, Yu Bao, Ying He, Siyi Li, Xiaojin Wang, Meiyun Chen, Kaiying Chen, Yuwei Zhang, Li Niu
Summary: Detection of heavy metal ions in water is an important topic in the field of analytical chemistry and environmental science. In this study, a novel strategy for determining the total content of heavy metal ions in water using fluorescence spectroscopy was developed. Fluorescent nitrogen, sulfur co-doped carbon quantum dots were prepared and showed a wide linear response to a series of water-soluble metal ions. The N, S-CQDs were also found to effectively remove heavy metal ions from water.
Article
Chemistry, Analytical
Farid Ahmed, Shahzad Iqbal, Long Zhao, Hai Xiong
Summary: The study developed a fluorescence sensor based on N,S-CDs for selective detection of mercury ions and guanine, which can be successfully applied for the detection of mercury ions in water samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Engineering, Chemical
Zhihua Xiao, Zhiqing Yu, Xinlong Ma, Chunming Xu
Summary: Nanostructured carbon materials are widely used as host materials for improving the performance of elemental sulfur in Li-S batteries. S, N-codoped carbon capsules (SNCCs) with microporous walls are used as the sulfur host material, providing high sulfur loading capacity, efficient suppression of shuttle effect, and exhibiting outstanding electrochemical performance.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Sardar Paydar, Foroozan Feizi, Mojtaba Shamsipur, Ali Barati, Neda Chehri, Avat (Arman) Taherpour, Morteza Jamshidi
Summary: Carbon dots were modified with glutathione to create a highly sensitive and selective fluorescent probe for the detection of Pb2+. The modified carbon dots showed different emission peaks in the presence of Pb2+, allowing for ratiometric detection. Theoretical calculations explained the mechanism behind the modification and binding process.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Elias Aboobakri, Tahereh Heidari, Moslem Jahani
Summary: Sulfur and nitrogen co-doped carbon dots (NSCDs) were synthesized quickly using the microwave-assisted method. The NSCDs exhibited a quantum yield of 11.5% with excitation and emission bands at 355 and 432 nm, respectively. The synthesized CDs were used as a sensitive probe for detecting Pb(II) in water and food samples, showing satisfying results.
Article
Chemistry, Analytical
Shulong Wang, Liangliang Zhang, Yanni Luo, Yulong Bai, Yong Huang, Shulin Zhao
Summary: Drug toxicity is a long-term concern in medical research, especially when it causes liver injury. However, improving the diagnosis and treatment of drug-induced liver injury remains a major challenge. This study presents a new dual-mode nanoprobe that can be used for both circular dichroism and photoacoustic imaging to monitor drug-induced liver injury.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Shulong Wang, Jingjin Zhao, Liangliang Zhang, Chaobang Zhang, Zhidong Qiu, Shulin Zhao, Yong Huang, Hong Liang
Summary: The Ox-POM@Cu nanocomposite demonstrates unique enzymatic functions in the tumor microenvironment, including multi-element catalytic activity and NIR-II photoacoustic imaging capabilities. By reacting with glutathione and hydrogen peroxide, it performs photothermal therapy and chemodynamic therapy functions, effectively diagnosing and treating malignant tumors.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhidong Qiu, Chaobang Zhang, Liangliang Zhang, Shulong Wang, Shengqiang Hu, Shulin Zhao
Summary: The weak interaction between light and biological tissues in the second near-infrared window can enhance the resolution and sensing ability of in vivo photoacoustic imaging. To address the challenges of developing a NIR-II photoacoustic probe, an organic dye was used to develop Hydro-1048 as the first NIR-II photoacoustic probe for imaging hydroxy radicals. The probe showed a strong photoacoustic signal after irradiation with a 1065 nm laser, allowing for noninvasive high-resolution imaging of hydroxy radicals in deep tissue.
Article
Chemistry, Analytical
Chaobang Zhang, Zhidong Qiu, Liangliang Zhang, Shulong Wang, Shulin Zhao, Qiufang Pang, Hong Liang
Summary: Multispectral optoacoustic tomography (MSOT) technique allows high-resolution molecular imaging in deep tissues, providing significant potential for clinical applications. In this study, a dual-modality imaging probe named APSA, responsive to superoxide anion, was developed for early diagnosis of drug-induced liver injury (DILI). The developed MSOT imaging method enables noninvasive and in situ visual diagnosis of DILI, while the fluorescence imaging method can be used for imaging endogenous superoxide anion and anatomical diagnosis of liver injury.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yulong Bai, Jingjin Zhao, Liangliang Zhang, Shulong Wang, Jing Hua, Shulin Zhao, Hong Liang
Summary: The study presents a method for achieving tumor microenvironment-activated cancer imaging and chemodynamic-photothermal combined therapy using smart near-infrared carbon dot-metal organic framework assemblies. This approach allows for efficient synergistic chemodynamic-photothermal dual mode therapy under fluorescence imaging guidance with TME response.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Analytical
Shengqiang Hu, Lixian Huang, Liuyan Zhou, Tingchan Wu, Shulin Zhao, Liangliang Zhang
Summary: This research focuses on the integration of ratiometric NIR-II fluorescence imaging and chemo-/photodynamic combination therapy for accurate diagnosis and efficient treatment of deep tumors. By conjugating dual-ligands-stabilized gold nanoclusters (cgAuNCs) into down-/up-conversion nanoparticles (D/UCNPs), single-excitation triple-emission nanoassemblies were prepared, enabling simultaneous imaging and therapy upon exposure to an 808 nm laser. The study provides insights into the design of multifunctional nanoplatforms for tumor diagnosis and treatment.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shengyu Chen, Jingjin Zhao, Chunhuan Xu, Liangliang Zhang, Bingfang Shi, Jianniao Tian, Shulin Zhao
Summary: Single-cell protein analysis is crucial for understanding cellular heterogeneity and biology. This study proposes an intracellular multicomponent synchronous DNA-walking strategy for quantifying multiple tumor-associated proteins simultaneously in a single cell. By amplifying the signals of nucleolin and thymidine kinase 1 using a nanoprobe based on a DNA walker, the absolute quantification of these proteins in single cells was achieved. The results demonstrate the overexpression of nucleolin and thymidine kinase 1 in liver cancer cells compared to normal hepatocytes.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Zhifang Li, Shulong Wang, Jingjin Zhao, Yanni Luo, Hong Liang, Shulin Zhao, Liangliang Zhang
Summary: Tumor microenvironment-responsive imaging and therapy using nanocomposite materials (AMDAs) has been developed for accurate and efficient diagnosis and treatment of cancer. The AMDAs enable high-resolution imaging of tumor tissues through NIR-II PA imaging and enhance tumor photothermal imaging and therapy. This work establishes an integrated platform for nanodiagnosis and treatment of cancer.
ADVANCED THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Shengkai Zhang, Lijia Yao, Xiaofei Lv, Meijun Lu, Fengli Gao, Liangliang Zhang, Shulin Zhao, Shengqiang Hu
Summary: Fluorescence-assisted digital counting analysis was achieved by engineering fluorescent dye-stained cancer cells with magnetic nanoparticles to construct single-cell probes for sensitive quantification of targets. Various engineering strategies, including biological recognition and chemical modification, were used to design rational single-cell probes. The advantages of single-cell probes, such as high brightness, large size, ease of preparation, and magnetic separation, contributed to the sensitive and selective analysis of targets of interest.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Yanni Luo, Liangliang Zhang, Shulong Wang, Yang Wang, Jing Hua, Changchun Wen, Shulin Zhao, Hong Liang
Summary: The development of tumor microenvironment-activated nanoassemblies that can produce a photoacoustic signal and enhance H2O2 level is crucial for accurate diagnosis and efficient chemodynamic therapy. In this study, nanoassemblies consisting of oxygen vacancy titanium dioxide, copper-sulfur-doped mesoporous organosilica, and glucose oxidase were developed. These nanoassemblies showed synergistic multimodal tumor treatment through TME-activated NIR-II PA imaging and photothermal-enhanced gas starvation-primed CDT, making them an excellent tumor diagnosis-treatment agent.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhaoguo Hong, Jingjing Zhong, Dangdang Ding, Sihui Gong, Liangliang Zhang, Shulin Zhao, Xing-Can Shen, Hong Liang, Fu-Ping Huang
Summary: An atomically precise cinnamaldehyde-derived metal-organic Cu(i) complex was constructed, which could generate large amounts of hydroxyl radicals in the mitochondria of HeLa cells. The complex showed cytotoxicity and inhibited tumor growth in vitro and in vivo, providing a controllable strategy for ROS-involved cancer therapy.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhaoguo Hong, Xin You, Jingjing Zhong, Di Yao, He-Dong Bian, Shulin Zhao, Liangliang Zhang, Hong Liang, Fu-Ping Huang
Summary: This study successfully synthesized a targeted Fenton-like agent, VBio-(CuCuII)-Cu-I, which demonstrated high selectivity and cytotoxicity towards tumor cells and could generate highly active hydroxyl radicals through Fenton reactions at the tumor site, resulting in significant inhibition of tumor growth.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Lifang Pang, Xiaolan Tang, Lijia Yao, Liuyan Zhou, Shengqiang Hu, Shulin Zhao, Liangliang Zhang
Summary: In this study, smart up/downconversion nanomachines were constructed by modifying DNA logic circuits on nanoparticles, enabling precise and efficient photodynamic therapy (PDT) for target tumors using near-infrared light. The biodistribution of the nanomachines in vivo could be visualized using NIR-II fluorescence imaging, contributing to precise PDT. This work provides new insights into the development of precise and highly efficient PDT systems.
Article
Chemistry, Analytical
Liuyan Zhou, Xiaokun Li, Luyin Wang, Zhihong Zhou, Shengqiang Hu, Shulin Zhao, Liangliang Zhang
Summary: Upconversion luminescence-activated DNA nanomachines with a fluid multivalent recognition interface were developed for rapid and sensitive in vivo imaging. These nanomachines can achieve an accelerated reaction rate and improved amplification capability.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jingjing Zhong, Zhaoguo Hong, Sudi Huang, Qiongqiong Zhong, Liangliang Zhang, Shulin Zhao, Hong Liang, Fu-Ping Huang
Summary: A novel copper complex Fc-OD-Cu was synthesized and designed for efficient chemodynamic therapy. Fc-OD-Cu can generate highly reactive hydroxyl radicals through a reaction induced by copper moieties, resulting in higher therapeutic efficiency compared to other compounds.
DALTON TRANSACTIONS
(2022)