期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 5, 期 4, 页码 3465-3470出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.7b00145
关键词
Spiro[dihydroquinoline-naphthofuranone] compound; Isatin; Hydrogen-bonding effect; Ring-opening and cyclization process
资金
- Natural Science Foundation of China [21402093]
- Jiangsu Province of China [BK20140776]
- Hainan Province of China [20162033]
- Chinese Postdoctoral Science Foundation [2016T90465, 2015M571761]
- Cultivation Research Foundation of Hainan Medical University [HY2015-02]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A one-pot, catalyst-free route to spiro[dihydroquinoline-naphthofuranone] compounds from isatins through ring-opening and cyclization processes in water is disclosed. Hydrogen-bonding effects of water proved to be the key factor to accelerate the transformation. In addition, the chemistry provides several advantages including that it is free of organic solvents, a simple operation, and a gram-scale synthesis and uses inexpensive reagents and a recyclable reaction medium.
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