Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA Oncoprotein

Biophysical Evidence for Intrinsic Disorder in the C-terminal Tails of the Epidermal Growth Factor Receptor (EGFR) and HER3 Receptor Tyrosine Kinases

(2016) Theodore R. Keppel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA

(2016) Asako Shimoda et al.   Scientific Reports

Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b

(2016) Hiroko Nishikawa et al.   Scientific Reports

SnapShot: Intrinsic Structural Disorder

(2015) Mainak Guharoy et al.   CELL

Intrinsically disordered proteins: emerging interaction specialists

(2015) Peter Tompa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins in cellular signalling and regulation

(2015) Peter E. Wright et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis

(2015) Lisa Nagase et al.   Scientific Reports

Helicobacter pylori CagA and Gastric Cancer: A Paradigm for Hit-and-Run Carcinogenesis

(2014) Masanori Hatakeyama   Cell Host & Microbe

Structural Disorder in Viral Proteins

(2014) Bin Xue et al.   CHEMICAL REVIEWS

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

(2013) Martin Schwalbe et al.   BIOCHEMISTRY

Natural variant of theHelicobacter pyloriCagA oncoprotein that lost the ability to interact with PAR1

(2013) Kana Hashi et al.   CANCER SCIENCE

Conformational Analysis of Isolated Domains of Helicobacter pylori CagA

(2013) Amanda P. Woon et al.   PLoS One

Association between cagA and vacA genotypes and pathogenesis in a Helicobacter pylori infected population from South-eastern Sweden

(2012) Anneli Karlsson et al.   BMC MICROBIOLOGY

Tertiary Structure-Function Analysis Reveals the Pathogenic Signaling Potentiation Mechanism of Helicobacter pylori Oncogenic Effector CagA

(2012) Takeru Hayashi et al.   Cell Host & Microbe

Bacterial EPIYA effectors - Where do they come from? What are they? Where are they going?

(2012) Takeru Hayashi et al.   CELLULAR MICROBIOLOGY

Structural insights into Helicobacter pylori oncoprotein CagA interaction with  1 integrin

(2012) B. Kaplan-Turkoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuated CagA Oncoprotein inHelicobacter pylorifrom Amerindians in Peruvian Amazon

(2011) Masato Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polarity-regulating Kinase Partitioning-defective 1b (PAR1b) Phosphorylates Guanine Nucleotide Exchange Factor H1 (GEF-H1) to Regulate RhoA-dependent Actin Cytoskeletal Reorganization

(2011) Yukie Yamahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Order and disorder in large multi-site docking proteins of the Gab family—implications for signalling complex formation and inhibitor design strategies

(2011) Philip C. Simister et al.   Molecular BioSystems

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Evolution of cagA Oncogene of Helicobacter pylori through Recombination

(2011) Yoshikazu Furuta et al.   PLoS One

Helicobacter pylori Exploits Host Membrane Phosphatidylserine for Delivery, Localization, and Pathophysiological Action of the CagA Oncoprotein

(2010) Naoko Murata-Kamiya et al.   Cell Host & Microbe

Cytoskeleton-modulating effectors of enteropathogenic and enterohemorrhagic Escherichia coli: a case for EspB as an intrinsically less-ordered effector

(2010) Daizo Hamada et al.   FEBS Journal

The Versatility of Helicobacter pylori CagA Effector Protein Functions: The Master Key Hypothesis

(2010) Steffen Backert et al.   HELICOBACTER

Host-Interactive Genes in Amerindian Helicobacter pylori Diverge from Their Old World Homologs and Mediate Inflammatory Responses

(2010) S. P. Mane et al.   JOURNAL OF BACTERIOLOGY

Helicobacter pylori from Peruvian Amerindians: Traces of Human Migrations in Strains from Remote Amazon, and Genome Sequence of an Amerind Strain

(2010) Dangeruta Kersulyte et al.   PLoS One

Could Helicobacter pylori play an important role in axonal type of Guillain-Barré Syndrome pathogenesis?

(2009) Mojdeh Ghabaee et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Differential oncogenic potential of geographically distinctHelicobacter pyloriCagA isoforms in mice

(2009) Motohiro Miura et al.   INTERNATIONAL JOURNAL OF CANCER

Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates

(2009) Dragana Nes̆ić et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Comprehensive Sequence and Disease Correlation Analyses for the C-Terminal Region of CagA Protein of Helicobacter pylori

(2009) Youlin Xia et al.   PLoS One

The tyrosine phosphatase Shp2 (PTPN11) in cancer

(2008) Gordon Chan et al.   CANCER AND METASTASIS REVIEWS

Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity

(2008) Zaher Zeaiter et al.   CELLULAR MICROBIOLOGY

Intrinsic disorder in pathogenic and non-pathogenic microbes: discovering and analyzing the unfoldomes of early-branching eukaryotes

(2008) Amrita Mohan et al.   Molecular BioSystems

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA

(2008) M Hatakeyama   ONCOGENE

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

(2008) N. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intrinsic disorder in scaffold proteins: Getting more from less

(2008) Marc S. Cortese et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY