Review
Medicine, General & Internal
Robert Ossendorff, Alessandra Menon, Frank A. Schildberg, Pietro S. Randelli, Sebastian Scheidt, Christof Burger, Dieter C. Wirtz, Davide Cucchi
Summary: The global distribution and quality of studies using adipose tissue derivates in orthopedics were assessed through a systematic review. Among the 82 included studies, 70% focused on knee disorders, mainly osteoarthritis. Approximately 26% of the studies investigated expanded adipose-derived stem/stromal cells (ADSCs), with 72% of these using stromal vascular fraction (SVF). The overall quality of the studies varied, with a higher score found in studies involving expanded ADSCs compared to SVF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ibrahim Vargel, Ali Tuncel, Nilsu Baysal, Irem Hartuc-Cevik, Feza Korkusuz
Summary: SVF has the potential to modulate inflammation and initiate regeneration in joint tissues, making it a potential approach for treating knee osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Rawan Al-kharboosh, Jonathan Jude Perera, Alexandra Bechtle, Guojun Bu, Alfredo Quinones-Hinojosa
Summary: Neurodegenerative disorders are characterized by the irreversible loss of cognitive functions and CNS structures, and the lack of preventive and regenerative measures has led to traditional symptomatic management as the only available therapeutic recourse. However, recent research suggests that the adipose-derived stromal vascular fraction (SVF) may hold promise as a cellular treatment for neurodegenerative diseases, with improvements seen in clinical applications for conditions such as Multiple Sclerosis, Alzheimer's disease, and Parkinson's disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Fermin Robledo, Lila Gonzalez-Hodar, Pablo Tapia, Ana-Maria Figueroa, Fernando Ezquer, Victor Cortes
Summary: Researchers successfully extracted multipotent cells from the brown adipose tissue of newborn mice, forming adipose spheroids with complex organoid structure and enhanced leptin secretion upon insulin stimulation. These findings have important implications for the potential therapeutic application of adipose tissue-derived stromal vascular fraction cells.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Orthopedics
Naomasa Yokota, Stephen Lyman, Hiroto Hanai, Kazunori Shimomura, Wataru Ando, Norimasa Nakamura
Summary: This study is the first head-to-head comparison of adipose-derived stromal cells (ASCs) and stromal vascular fraction (SVF) for the treatment of knee osteoarthritis (OA). The results showed that both ASCs and SVF injections significantly improved knee pain and function. ASC injections demonstrated better improvements in pain visual analog scale (VAS) and Knee injury and Osteoarthritis Outcome Score 5 (KOOS5) at 12 months. The use of ASCs over SVF may be warranted in the treatment of knee OA.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Retraction
Medicine, Research & Experimental
Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim
Summary: The article has been retracted. Please refer to the Retraction Notice for more details: https://doi.org/10.1186/s12967-021-02852-z
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Tomoyuki Kamenaga, Yuichi Kuroda, Kanto Nagai, Masanori Tsubosaka, Yoshinori Takashima, Kenichi Kikuchi, Masahiro Fujita, Kemmei Ikuta, Kensuke Anjiki, Toshihisa Maeda, Naoki Nakano, Koji Takayama, Shingo Hashimoto, Shinya Hayashi, Takehiko Matsushita, Takahiro Niikura, Ryosuke Kuroda, Tomoyuki Matsumoto
Summary: The study found that SVF cells can enhance bone healing, with cryopreserved cells showing almost equal potential as fresh cells. SVF cells can be used to improve nonunion bone fracture healing as an alternative to other mesenchymal stem cells, and their effect can be maintained under cryopreservation.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Michael H. Carstens, Francisco J. Quintana, Santos T. Calderwood, Juan P. Sevilla, Arlen B. Rios, Carlos M. Rivera, Dorian W. Calero, Maria L. Zelaya, Nelson Garcia, Kenneth A. Bertram, Joseph Rigdon, Severiano Dos-Anjos, Diego Correa
Summary: This study demonstrates that stromal vascular fraction (SVF) cells can be safely used to treat chronic diabetic foot ulcers (DFUs) with evidence of wound healing and mechanisms of action that include vascular repair and/or angiogenesis.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Veterinary Sciences
Khan Sharun, Kaveri Jambagi, Rohit Kumar, Mudasir Bashir Gugjoo, Abhijit M. Pawde, Hardeep Singh Tuli, Kuldeep Dhama, Amarpal
Summary: Adipose tissue-derived stromal vascular fraction (AdSVF) is a heterogeneous cell population with therapeutic potential for various conditions, including osteoarthritis, wound healing, and orthopaedic disorders. Compared to in vitro expanded adipose tissue-derived mesenchymal stem cells (AdMSCs), AdSVF has several advantages.
VETERINARY QUARTERLY
(2022)
Review
Medicine, General & Internal
Albert Stachura, Wiktor Paskal, Weronika Pawlik, Maciej J. Mazurek, Janusz Jaworowski
Summary: Lipofilling has become a popular scar treatment method due to the regenerative capacity of adipose-derived stem cells (ADSCs) it utilizes. A systematic review of existing data suggests that ADSC-related interventions show beneficial effects in scar treatment, possibly comparable to other interventions like platelet-rich plasma or CO2 fractional laser.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
S. Gandolfi, B. Pileyre, L. Drouot, I. Dubus, I. Auquit-Auckbur, J. Martinet
Summary: Muscle regeneration is a complex process that requires precise interaction between immune and muscular cells. The mechanisms underlying autoimmune myopathies are not fully understood, but chronic inflammation and decreased muscle regenerative capacity play a role. Immunosuppressive treatments can be ineffective, and alternative therapies such as stromal vascular fraction show promise but lack a clear understanding of their active components and mechanisms of action.
CELL DEATH DISCOVERY
(2023)
Article
Cell & Tissue Engineering
Kensuke Anjiki, Tomoyuki Matsumoto, Yuichi Kuroda, Masahiro Fujita, Shinya Hayashi, Naoki Nakano, Masanori Tsubosaka, Tomoyuki Kamenaga, Yoshinori Takashima, Kenichi Kikuchi, Kenmei Ikuta, Yuma Onoi, Shotaro Tachibana, Yoshihito Suda, Kensuke Wada, Takehiko Matsushita, Ryosuke Kuroda
Summary: This study aimed to investigate the therapeutic effects of heterogeneous cells in rabbit stromal-vascular fraction (SVF) on rabbit chondrocytes. It was found that the SVF group showed superior therapeutic effects compared to the low-dose adipose-derived stromal cells (lADSC) group. The SVF group mainly consisted of M2 macrophages, which secreted growth factors and chondrocyte-protective cytokines, benefiting chondrocytes and knee joint homeostasis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Medicine, General & Internal
Lucy V. Trevor, Kirsten Riches-Suman, Ajay L. Mahajan, M. Julie Thornton
Summary: This study aims to isolate stromal vascular fraction from human breast tissue exposed to radiotherapy and determine the presence of adipose-derived stem cells. The results show that stromal vascular fraction from irradiated donors has a similar effect in stimulating the migration of dermal fibroblasts as pre-adipocyte conditioned media from healthy donors. Thus, the functionality of adipose-derived stem cells appears to be preserved following radiotherapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Kevin M. Urlaub, Kavitha Ranganathan, Jeremy V. Lynn, Alexandra O. Luby, Lauren N. Patrick, Noah S. Nelson, Alexis Donneys, Steven R. Buchman
Summary: Stromal vascular fraction therapy has shown significant efficacy in enhancing bone healing in irradiated fracture repair, improving union rates and bone vascularization metrics while restoring bone cellularity and maturity despite preoperative irradiation. This study provides a promising foundation for the development of noncultured, cell-based therapies for clinical implementation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Surgery
Elif Tuncay, Ozan Akinci, Asiye Perek, Esin Aktas Cetin, Nuray Kepil, Murat Toksoy, Nurdan Altan
Summary: The adipose-derived stromal vascular fraction cells obtained from inguinal lipectomy material in rats positively influence the repair of abdominal incisional hernias by increasing peritoneal formation and reducing structural distortion and PMNL infiltration.
JOURNAL OF INVESTIGATIVE SURGERY
(2022)
Article
Orthopedics
Mike Mikkelsen Lorenzen, Lotte Poulsen, Christoffer Bing Madsen, Elena Tsangaris, Anne Klassen, Jens Ahm Sorensen
Summary: The aim of this study was to translate and adapt the BODY-Q Obesity Module for Danish patients. The translation process involved several steps to ensure linguistic and cultural appropriateness. The final translated version was well received and found to be conceptually and culturally equivalent to the original instrument. This translation can be used in both clinical care and research to advance the field of bariatric and body contouring surgery.
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
(2022)
Article
Endocrinology & Metabolism
Farima Dalaei, Claire E. E. de Vries, Lotte Poulsen, Manraj N. Kaur, Andre Pfob, Danny Mou, Amalie L. Jacobsen, Jussi P. Repo, Rosa Salzillo, Jakub Opyrchal, Anne F. Klassen, Jens Ahm Sorensen, Andrea L. Pusic
Summary: This study determined normative values for the BODY-Q scales in patients undergoing weight loss and/or body contouring surgery, providing valuable information for interpreting BODY-Q scores and understanding the impact of these surgeries on patients' lives.
Article
Endocrinology & Metabolism
Amalie L. Jacobsen, Claire E. E. DeVries, Lotte Poulsen, Danny Mou, Anne F. Klassen, Andrea L. Pusic, Dennis J. S. Makarawung, Marinus J. Wiezer, Ruben N. van Veen, Jens A. Sorensen
Summary: Obesity has a significant impact on health-related quality of life, and work life satisfaction is influenced by body mass index (BMI), with higher BMI being associated with lower satisfaction. This study suggests that reducing BMI may have a positive influence on work life satisfaction in people with obesity.
Article
Endocrinology & Metabolism
Phillip J. Dijkhorst, Claire E. E. de Vries, Danny Mou, Lotte Poulsen, Jens A. Sorensen, Maarten M. Hoogbergen, Ruben N. van Veen, Anne F. Klassen, Andrea L. Pusic
Summary: Many people with obesity have unrealistic expectations before bariatric surgery, leading to negative psychological outcomes. Younger age and non-white race were significant predictors for higher expectations.
Article
Oncology
Frederik C. Gulmark Hansen, Mads Gustaf Jorgensen, Jens Ahm Sorensen
Summary: Tacrolimus treatment was found to be safe and effective in reducing symptoms of BCRL, improving the quality of life of patients, and positively impacting lymph flow and function. However, larger randomized controlled trials are needed to confirm these findings, as the sample size of this study was small and there was no control group.
JOURNAL OF BREAST CANCER
(2023)
Article
Surgery
Lotte Poulsen, Charlene Rae, Nina Simonsen, Anne F. Klassen, Mike Lorenzen, Michael Rose, Claus B. Juhl, Rene Klinkby Stoving, Stefan J. Cano, Alin Andries, Andrea L. Pusic, Jens Ahm Sorensen
Summary: This study investigated the impact of bariatric surgery (BaS) and body contouring surgery (BC) on patients' satisfaction with appearance and health-related quality of life (HR-QOL) using the BODY-Q measure. The results showed that both BaS and BC improved patients' satisfaction and HR-QOL, with BC playing a crucial role in maintaining the improvements.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Letter
Surgery
Martin Sollie, Navid Toyserkani, Camilla Bille, Jorn B. Thomsen, Jens A. Sorensen
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Surgery
Phillip J. Dijkhorst, Dennis J. S. Makarawung, Joost W. Vanhommerig, Suzanne C. Kleipool, Farima Dalaei, Claire E. E. de Vries, Aebele B. van der Molen, Lotte Poulsen, Jens A. Sorensen, H. Jaap Bonjer, Steve M. M. de Castro, Ruben N. van Veen
Summary: The study aimed to evaluate the factors that affect psychological function following bariatric surgery. The results showed that patients with lower expectations of weight loss, higher educational level, no history of psychiatric illness, and employment before surgery had higher psychological function scores. Additionally, more weight loss after 1 to 2 years post-surgery was associated with higher psychological function scores.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Medicine, General & Internal
Christoffer Bing Madsen, Lotte Poulsen, Vivi Bakholdt, Jens Ahm Sorensen
Summary: We present a rare case of microsurgical replantation of a total scalp avulsion in a woman in her mid-60s. The avulsion occurred when her hair was caught in a column drill while renovating a tractor. The prehospital management and conservation packing of the scalp were highly effective.
Review
Dermatology
Knaerke Soegaard, Martin Sollie, Dimitri Beeckman, Fin Biering-Sorensen, Jens Ahm-Sorensen
Summary: This scoping review aimed to provide an overview of initiatives, organisational components, and stakeholders' perspectives on pressure ulcer (PU) prevention in transitional care. Fifteen studies of various types were included, indicating that continuous tailored education and information, as well as follow-up services, are crucial for preventing PUs and rehabilitating patients with spinal cord injuries (SCI). However, there is a discrepancy between international recommendations, perceived needs, and the delivery of healthcare services, resulting in lower quality of life and higher risk of PUs for individuals with SCI.
JOURNAL OF TISSUE VIABILITY
(2023)
Article
Oncology
Ida Grunske Schmidt, Malene Korsholm, Jorgen Johansen, Jens Ahm Sorensen, Christian Godballe, Kristine Bjorndal
Summary: The Danish head and neck cancer fast-track program aims to reduce waiting time and improve survival for patients suspected of cancer. This study found a low frequency of missed cancers in the program, indicating its accuracy and effectiveness.
Article
Oncology
Mads G. Jorgensen, Ebru Gozeri, Tanja G. Petersen, Jens A. Sorensen
Summary: Surgical-site infection is a common complication after breast cancer treatment and may increase the risk of breast cancer-related lymphedema. A nationwide registry-based study showed that there was a 10% increased risk of breast cancer-related lymphedema associated with surgical-site infection. These findings can help identify high-risk patients who would benefit from enhanced surveillance.
CLINICAL BREAST CANCER
(2023)
Article
Pediatrics
Christopher Emil Jonsson, Lotte Poulsen, Jan Duedal Roelfing, Harpreet Chhina, Anthony Cooper, Jens Ahm Sorensen
Summary: This study aimed to perform a translation and cultural adaption of the LIMB-Q Kids for use in Danish-speaking children, following guidelines established by WHO and ISPOR. The TCA process resulted in a linguistically validated and culturally adapted Danish version of LIMB-Q Kids, which is now being used in an international field test study.
Article
Surgery
Farima Dalaei, Claire E. E. de Vries, Stefan J. Cano, Manraj N. Kaur, Lotte Poulsen, Andre Pfob, Danny Mou, Jussi P. Repo, Rosa Salzillo, Jakub Opyrchal, Jens A. Sorensen, Andrea L. Pusic, Anne F. Klassen
Summary: This study examined the psychometric properties of the patient-reported outcome measure BODY-Q in a normative population. The results showed that the BODY-Q scales had acceptable reliability and validity in the normative sample, and can be used as reference values in research and clinical practice.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Article
Medicine, General & Internal
Christoffer Bing Madsen, Max Rohde, Oke Gerke, Christian Godballe, Jens Ahm Sorensen
Summary: This study investigated the diagnostic accuracy of up-front 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and MRI for detecting cervical lymph node metastases in patients with T1-T2 oral squamous cell carcinoma. The results showed that PET/CT had higher sensitivity but lower specificity compared to neck MRI, and the overall accuracy of both imaging modalities was comparable. Therefore, a combination of PET/CT and MRI should be used for diagnosing cervical lymph node metastases in T1-T2 oral cavity cancer.