Endothelial cell tropism is a determinant of H5N1 pathogenesis in mammalian species

The Tie2-agonist Vasculotide rescues mice from influenza virus infection

(2015) Michael G. Sugiyama et al.   Scientific Reports

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

Influenza virus and endothelial cells: a species specific relationship

(2014) Kirsty R. Short et al.   Frontiers in Microbiology

Pathogenesis of influenza-induced acute respiratory distress syndrome

(2013) Kirsty R Short et al.   LANCET INFECTIOUS DISEASES

MicroRNA-based strategy to mitigate the risk of gain-of-function influenza studies

(2013) Ryan A Langlois et al.   NATURE BIOTECHNOLOGY

Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection

(2013) Susan M Armstrong et al.   Virulence

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

(2012) E. J. A. Schrauwen et al.   JOURNAL OF VIROLOGY

Influenza Infects Lung Microvascular Endothelium Leading to Microvascular Leak: Role of Apoptosis and Claudin-5

(2012) Susan M. Armstrong et al.   PLoS One

Influenza-Infected Neutrophils within the Infected Lungs Act as Antigen Presenting Cells for Anti-Viral CD8+ T Cells

(2012) Matthew M. Hufford et al.   PLoS One

Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune responses

(2012) Ryan A. Langlois et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

MicroRNA profiling of diverse endothelial cell types

(2011) Matthew N McCall et al.   BMC Medical Genomics

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

The first influenza pandemic of the new millennium

(2011) Gabriele Neumann et al.   Influenza and Other Respiratory Viruses

Marked Endotheliotropism of Highly Pathogenic Avian Influenza Virus H5N1 following Intestinal Inoculation in Cats

(2011) L. A. Reperant et al.   JOURNAL OF VIROLOGY

Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection

(2011) H. Zeng et al.   JOURNAL OF VIROLOGY

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

Differential Contribution of PB1-F2 to the Virulence of Highly Pathogenic H5N1 Influenza A Virus in Mammalian and Avian Species

(2011) Mirco Schmolke et al.   PLoS Pathogens

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response

(2010) D. Viemann et al.   JOURNAL OF IMMUNOLOGY

Influenza Virus–Cytokine‐Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza

(2010) Siye Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus

(2010) B. Manicassamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

Viral Replication Rate Regulates Clinical Outcome and CD8 T Cell Responses during Highly Pathogenic H5N1 Influenza Virus Infection in Mice

(2010) Yasuko Hatta et al.   PLoS Pathogens

Effect of dexamethasone on acute respiratory distress syndrome induced by the H5N1 virus in mice

(2009) T. Xu et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic infection of avian influenza A virus H5N1 subtype in humans

(2009) Zengfeng Zhang et al.   HUMAN PATHOLOGY

Hemagglutinin-Dependent Tropism of H5N1 Avian Influenza Virus for Human Endothelial Cells

(2009) M. Ocana-Macchi et al.   JOURNAL OF VIROLOGY

MicroRNA-mediated species-specific attenuation of influenza A virus

(2009) Jasmine T Perez et al.   NATURE BIOTECHNOLOGY

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

(2009) C. R. Baskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling

(2009) Anna A. Birukova et al.   Translational Research

Innate immune responses to influenza A H5N1: friend or foe?

(2009) Joseph Sriyal Malik Peiris et al.   TRENDS IN IMMUNOLOGY

Lethal Influenza Virus Infection in Macaques Is Associated with Early Dysregulation of Inflammatory Related Genes

(2009) Cristian Cillóniz et al.   PLoS Pathogens

Pathology, Molecular Biology, and Pathogenesis of Avian Influenza A (H5N1) Infection in Humans

(2008) Christine Korteweg et al.   AMERICAN JOURNAL OF PATHOLOGY

Live Attenuated Influenza Viruses Containing NS1 Truncations as Vaccine Candidates against H5N1 Highly Pathogenic Avian Influenza

(2008) J. Steel et al.   JOURNAL OF VIROLOGY

Genetic Compatibility and Virulence of Reassortants Derived from Contemporary Avian H5N1 and Human H3N2 Influenza A Viruses

(2008) Li-Mei Chen et al.   PLoS Pathogens

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens