Cross-seeding of prions by aggregated α-synuclein leads to transmissible spongiform encephalopathy

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes

(2017) Jakob Domert et al.   PLoS One

Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo

(2016) Bruno Vasconcelos et al.   ACTA NEUROPATHOLOGICA

New Molecular Insight into Mechanism of Evolution of Mammalian Synthetic Prions

(2016) Natallia Makarava et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau pathology in Creutzfeldt-Jakob disease revisited

(2016) Gabor G. Kovacs et al.   BRAIN PATHOLOGY

The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity

(2016) Timothy S. Jarvela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multifaceted Role of Sialylation in Prion Diseases

(2016) Ilia V. Baskakov et al.   Frontiers in Neuroscience

Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence

(2016) Emma Sierecki et al.   Scientific Reports

The diversity and relationship of prion protein self-replicating states

(2015) Nina Klimova et al.   VIRUS RESEARCH

Two alternative pathways for generating transmissible prion disease de novo

(2015) Natallia Makarava et al.   Acta Neuropathologica Communications

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

(2014) Gabor G. Kovacs et al.   NEUROBIOLOGY OF DISEASE

Distinct synthetic A  prion strains producing different amyloid deposits in bigenic mice

(2014) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serial propagation of distinct strains of A  prions from Alzheimer's disease patients

(2014) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevalence of mixed pathologies in the aging brain

(2014) Jasmin Rahimi et al.   Alzheimers Research & Therapy

Atypical and Classical Forms of the Disease-Associated State of the Prion Protein Exhibit Distinct Neuronal Tropism, Deposition Patterns, and Lesion Profiles

(2013) Gabor G. Kovacs et al.   AMERICAN JOURNAL OF PATHOLOGY

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Wildtype and A30P Mutant Alpha-Synuclein Form Different Fibril Structures

(2013) Søren Bang Nielsen et al.   PLoS One

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

The Evolution of Transmissible Prions: The Role of Deformed Templating

(2013) Natallia Makarava et al.   PLoS Pathogens

Chronic Wasting Disease in Bank Voles: Characterisation of the Shortest Incubation Time Model for Prion Diseases

(2013) Michele Angelo Di Bari et al.   PLoS Pathogens

Selective Amplification of Classical and Atypical Prions Using Modified Protein Misfolding Cyclic Amplification

(2012) Natallia Makarava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of a Prion Strain of Synthetic Origin Requires Multiple Serial Passages

(2012) Natallia Makarava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Mechanism for Transmissible Prion Diseases

(2012) N. Makarava et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice

(2012) Eliezer Masliah et al.   Prion

Fast and ultrasensitive method for quantitating prion infectivity titre

(2012) Natallia Makarava et al.   Nature Communications

Transmission of Prion Strains in a Transgenic Mouse Model Overexpressing Human A53T Mutated α-Synuclein

(2011) Anne-Laure J. Mougenot et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

“Preclinical” MSA in definite Creutzfeldt-Jakob disease

(2011) Roberta Rodriguez-Diehl et al.   NEUROPATHOLOGY

Genesis of Mammalian Prions: From Non-infectious Amyloid Fibrils to a Transmissible Prion Disease

(2011) Natallia Makarava et al.   PLoS Pathogens

Highly Efficient Protein Misfolding Cyclic Amplification

(2011) Nuria Gonzalez-Montalban et al.   PLoS Pathogens

Variably protease-sensitive prionopathy in a PRNP codon 129 heterozygous UK patient with co-existing tau, α synuclein and Aβ pathology

(2010) Mark W. Head et al.   ACTA NEUROPATHOLOGICA

Genetic Creutzfeldt-Jakob disease associated with the E200K mutation: characterization of a complex proteinopathy

(2010) Gabor G. Kovacs et al.   ACTA NEUROPATHOLOGICA

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Switching in amyloid structure within individual fibrils: Implication for strain adaptation, species barrier and strain classification

(2009) Ilia V. Baskakov   FEBS LETTERS

The Nigrostriatal Pathway in Creutzfeldt-Jakob Disease

(2009) Anne Vital et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA