Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni

Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs

(2016) Gerard L. Brien et al.   CANCER CELL

Comprehensive Transcriptome Analysis of Sex-Biased Expressed Genes Reveals Discrete Biological and Physiological Features of Male and Female Schistosoma japonicum

(2016) Pengfei Cai et al.   PLoS Neglected Tropical Diseases

Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo

(2016) Julie N. R. Collins et al.   PLoS Pathogens

What is the mechanism of action of praziquantel and how might resistance strike?

(2015) Pauline M Cupit et al.   Future Medicinal Chemistry

Histone exchange, chromatin structure and the regulation of transcription

(2015) Swaminathan Venkatesh et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq

(2015) Letícia Anderson et al.   PLoS Neglected Tropical Diseases

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

(2015) David Roquis et al.   PLoS Neglected Tropical Diseases

Schistosomiasis therapeutics: whats in the pipeline?

(2015) Santiago Trainor-Moss et al.   Expert Review of Clinical Pharmacology

Exposure to hycanthone alters chromatin structure around specific gene functions and specific repeats in Schistosoma mansoni

(2014) David Roquis et al.   Frontiers in Genetics

Adult somatic stem cells in the human parasite Schistosoma mansoni

(2013) James J. Collins III et al.   NATURE

New approaches for understanding mechanisms of drug resistance in schistosomes

(2013) ROBERT M. GREENBERG   PARASITOLOGY

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

(2013) Hong Wu et al.   PLoS One

Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

(2013) Stephen Antonysamy et al.   PLoS One

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

(2013) Julien Lancelot et al.   PLoS Neglected Tropical Diseases

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

(2013) Martin Marek et al.   PLoS Pathogens

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Schistosoma mansoni histones: From transcription to chromatin regulation; an in silico analysis

(2012) Letícia Anderson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide identification and characterization of a panel of house-keeping genes in Schistosoma japonicum

(2012) Shuai Liu et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Histone deacetylases and cancer

(2012) Bruna Barneda-Zahonero et al.   Molecular Oncology

Chromatin replication and epigenome maintenance

(2012) Constance Alabert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perceiving the epigenetic landscape through histone readers

(2012) Catherine A Musselman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

KoBaMIN: a knowledge-based minimization web server for protein structure refinement

(2012) J. P. G. L. M. Rodrigues et al.   NUCLEIC ACIDS RESEARCH

Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2

(2012) Sharad K. Verma et al.   ACS Medicinal Chemistry Letters

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

(2012) Anna V. Protasio et al.   PLoS Neglected Tropical Diseases

The Histone Chaperone Facilitates Chromatin Transcription (FACT) Protein Maintains Normal Replication Fork Rates

(2011) Takuya Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Combinatorial chromatin modification patterns in the human genome revealed by subspace clustering

(2011) Duygu Ucar et al.   NUCLEIC ACIDS RESEARCH

HDAC Activity Is Required during Xenopus Tail Regeneration

(2011) Ai-Sun Tseng et al.   PLoS One

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Inhibition of Histone Deacetylase in Cancer Cells Slows Down Replication Forks, Activates Dormant Origins, and Induces DNA Damage

(2010) Chiara Conti et al.   CANCER RESEARCH

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Eukaryotic DNA replication origins: many choices for appropriate answers

(2010) Marcel Méchali   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development and Validation of a Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability

(2010) Emily Peak et al.   PLoS Neglected Tropical Diseases

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Global Histone Analysis by Mass Spectrometry Reveals a High Content of Acetylated Lysine Residues in the Malaria ParasitePlasmodium falciparum

(2009) Morten B. Trelle et al.   JOURNAL OF PROTEOME RESEARCH

Quantitative chromatin immunoprecipitation (Q-ChIP) applied to Schistosoma mansoni

(2009) Stéphanie Caby et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni

(2009) Florence Dubois et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Improved prediction of protein side-chain conformations with SCWRL4

(2009) Georgii G. Krivov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Identification of the Schistosoma mansoni TNF-Alpha Receptor Gene and the Effect of Human TNF-Alpha on the Parasite Gene Expression Profile

(2009) Katia C. Oliveira et al.   PLoS Neglected Tropical Diseases

The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni

(2008) Frédérik Oger et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ontologizer 2.0--a multifunctional tool for GO term enrichment analysis and data exploration

(2008) S. Bauer et al.   BIOINFORMATICS

Histone deacetylase inhibitors and genomic instability

(2008) Grégory Eot-Houllier et al.   CANCER LETTERS