Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial

Differential visceral blood flow in the hyperdynamic circulation of patients with liver cirrhosis

(2016) N. C. McAvoy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Terlipressin Plus Albumin Is More Effective Than Albumin Alone in Improving Renal Function in Patients With Cirrhosis and Hepatorenal Syndrome Type 1

(2016) Thomas D. Boyer et al.   GASTROENTEROLOGY

International Criteria for Acute Kidney Injury: Advantages and Remaining Challenges

(2016) Nicholas M. Selby et al.   PLOS MEDICINE

Pharmacokinetics of serelaxin in patients with hepatic impairment: a single-dose, open-label, parallel group study

(2015) Zhanna Kobalava et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences

(2015) Alastair O'Brien et al.   LIVER INTERNATIONAL

Diverse Regulation of Cardiac Expression of Relaxin Receptor by α1- and β1-Adrenoceptors

(2014) Xiao-Lei Moore et al.   CARDIOVASCULAR DRUGS AND THERAPY

Acute kidney injury and acute-on-chronic liver failure classifications in prognosis assessment of patients with acute decompensation of cirrhosis

(2014) Paolo Angeli et al.   GUT

Albumin infusion improves renal blood flow autoregulation in patients with acute decompensation of cirrhosis and acute kidney injury

(2014) Rita Garcia-Martinez et al.   LIVER INTERNATIONAL

Localization of relaxin receptors in arteries and veins, and region-specific increases in compliance and bradykinin-mediated relaxation after in vivo serelaxin treatment

(2013) Maria Jelinic et al.   FASEB JOURNAL

Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis

(2013) Richard Moreau et al.   GASTROENTEROLOGY

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertensionin vivo

(2013) Jonathan A. Fallowfield et al.   HEPATOLOGY

Acute kidney injury in decompensated cirrhosis

(2012) Cynthia D Tsien et al.   GUT

Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression

(2012) Naina Shah et al.   JOURNAL OF HEPATOLOGY

Urinary neutrophil gelatinase-associated lipocalin as biomarker in the differential diagnosis of impairment of kidney function in cirrhosis

(2012) Claudia Fagundes et al.   JOURNAL OF HEPATOLOGY

Effect of Serelaxin on Cardiac, Renal, and Hepatic Biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) Development Program

(2012) Marco Metra et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Diesel exhaust particulate induces pulmonary and systemic inflammation in rats without impairing endothelial function ex vivo or in vivo

(2012) Sarah Robertson et al.   Particle and Fibre Toxicology

Relaxin Induces Rapid Dilation of Rodent Small Renal and Human Subcutaneous Arteries via PI3 Kinase and Nitric Oxide

(2011) Jonathan T. McGuane et al.   ENDOCRINOLOGY

Prognostic Importance of the Cause of Renal Failure in Patients With Cirrhosis

(2010) Marta Martín–Llahí et al.   GASTROENTEROLOGY

Unveiling the Vasodilatory Actions and Mechanisms of Relaxin

(2010) Kirk P. Conrad   HYPERTENSION

Assessment of splanchnic blood flow using magnetic resonance imaging

(2009) Daniel Barthelmes et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Low cardiac output predicts development of hepatorenal syndrome and survival in patients with cirrhosis and ascites

(2009) A Krag et al.   GUT

The spectrum of renal lesions in patients with cirrhosis: a clinicopathological study

(2009) Jean-Marie Trawalé et al.   LIVER INTERNATIONAL

Development of hepatorenal syndrome in bile duct ligated rats

(2008) Regina M Pereira et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Relationship Between Activation of the Sympathetic Nervous System and Renal Blood Flow Autoregulation in Cirrhosis

(2007) Vanessa P. Stadlbauer et al.   GASTROENTEROLOGY