Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Clusters of Multiple Mutations: Incidence and Molecular Mechanisms

(2015) Kin Chan et al.   Annual Review of Genetics

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

The hidden side of unstable DNA repeats: Mutagenesis at a distance

(2015) Kartik A. Shah et al.   DNA REPAIR

BRCA1 and CtIP promote alternative non-homologous end-joining at uncapped telomeres

(2015) S. Badie et al.   EMBO JOURNAL

DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination

(2015) Petr Cejka   JOURNAL OF BIOLOGICAL CHEMISTRY

Translesion Polymerases Drive Microhomology-Mediated Break-Induced Replication Leading to Complex Chromosomal Rearrangements

(2015) Cynthia J. Sakofsky et al.   MOLECULAR CELL

Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

(2015) Agnel Sfeir et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA Damage Response Factors from Diverse Pathways, Including DNA Crosslink Repair, Mediate Alternative End Joining

(2015) Sean M. Howard et al.   PLoS Genetics

Nuclear position dictates DNA repair pathway choice

(2014) Charlène Lemaître et al.   GENES & DEVELOPMENT

CNV instability associated with DNA replication dynamics: evidence for replicative mechanisms in CNV mutagenesis

(2014) Lu Chen et al.   HUMAN MOLECULAR GENETICS

RPA antagonizes microhomology-mediated repair of DNA double-strand breaks

(2014) Sarah K Deng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The role of microhomology in genomic structural variation

(2014) Diego Ottaviani et al.   TRENDS IN GENETICS

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

(2013) Marenda A. Wilson et al.   NATURE

Migrating bubble during break-induced replication drives conservative DNA synthesis

(2013) Natalie Saini et al.   NATURE

Replicative mechanisms for CNV formation are error prone

(2013) Claudia M B Carvalho et al.   NATURE GENETICS

Genome rearrangements caused by interstitial telomeric sequences in yeast

(2013) A. Y. Aksenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells

(2013) L. N. Truong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae

(2013) Natalie Saini et al.   PLoS Genetics

Mutations Arising During Repair of Chromosome Breaks

(2012) Anna Malkova et al.   Annual Review of Genetics

Somatic rearrangements across cancer reveal classes of samples with distinct patterns of DNA breakage and rearrangement-induced hypermutability

(2012) Y. Drier et al.   GENOME RESEARCH

Clustered Mutations in Yeast and in Human Cancers Can Arise from Damaged Long Single-Strand DNA Regions

(2012) Steven A. Roberts et al.   MOLECULAR CELL

Role of DNA Polymerases in Repeat-Mediated Genome Instability

(2012) Kartik A. Shah et al.   Cell Reports

Microhomology Directs Diverse DNA Break Repair Pathways and Chromosomal Translocations

(2012) Diana D. Villarreal et al.   PLoS Genetics

Double-Strand Break End Resection and Repair Pathway Choice

(2011) Lorraine S. Symington et al.   Annual Review of Genetics

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

Ku prevents Exo1 and Sgs1-dependent resection of DNA ends in the absence of a functional MRX complex or Sae2

(2010) Eleni P Mimitou et al.   EMBO JOURNAL

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

(2010) Eun Yong Shim et al.   EMBO JOURNAL

CtIP promotes microhomology-mediated alternative end joining during class-switch recombination

(2010) Mieun Lee-Theilen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A time-invariant principle of genome evolution

(2010) S. De et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased Mutagenesis and Unique Mutation Signature Associated with Mitotic Gene Conversion

(2010) W. M. Hicks et al.   SCIENCE

Defective Resection at DNA Double-Strand Breaks Leads to De Novo Telomere Formation and Enhances Gene Targeting

(2010) Woo-Hyun Chung et al.   PLoS Genetics

Fluctuation AnaLysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis

(2009) B. M. Hall et al.   BIOINFORMATICS

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

A Microhomology-Mediated Break-Induced Replication Model for the Origin of Human Copy Number Variation

(2009) P. J. Hastings et al.   PLoS Genetics

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

(2008) Hyun-Min Kim et al.   EMBO JOURNAL

Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

(2008) Christian Zierhut et al.   EMBO JOURNAL

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

(2008) Eleni P. Mimitou et al.   NATURE

Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations

(2008) Kihoon Lee et al.   NATURE

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Hypermutability of Damaged Single-Strand DNA Formed at Double-Strand Breaks and Uncapped Telomeres in Yeast Saccharomyces cerevisiae

(2008) Yong Yang et al.   PLoS Genetics

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics