Innate immunity mediated longevity and longevity induced by germ cell removal converge on the C-type lectin domain protein IRG-7

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans

(2015) J. Amaranath Govindan et al.   NATURE CELL BIOLOGY

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

(2015) Michael J Steinbaugh et al.   eLife

Chemosensation of Bacterial Secondary Metabolites Modulates Neuroendocrine Signaling and Behavior of C. elegans

(2014) Joshua D. Meisel et al.   CELL

The C-type lectin-like domain containing proteins Clec-39 and Clec-49 are crucial for Caenorhabditis elegans immunity against Serratia marcescens infection

(2014) S.M. Miltsch et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of C. elegans

(2014) Ramesh Ratnappan et al.   PLoS Genetics

Germline stem cell arrest inhibits the collapse of somatic proteostasis early inCaenorhabditis elegansadulthood

(2013) Netta Shemesh et al.   AGING CELL

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

Direct and Indirect Gene Regulation by a Life-Extending FOXO Protein in C. elegans: Roles for GATA Factors and Lipid Gene Regulators

(2013) Peichuan Zhang et al.   Cell Metabolism

Identifying evolutionarily conserved genes in the dietary restriction response using bioinformatics and subsequent testing in Caenorhabditis elegans

(2013) Andreas Hanno Ludewig et al.   Genes and Nutrition

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

(2013) Maria A. Ermolaeva et al.   NATURE

Antibacterial membrane attack by a pore-forming intestinal C-type lectin

(2013) Sohini Mukherjee et al.   NATURE

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

(2013) Eyleen J. O’Rourke et al.   NATURE CELL BIOLOGY

Autophagy links lipid metabolism to longevity inC. elegans

(2012) Louis R. Lapierre et al.   Autophagy

Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses

(2012) Justine A. Melo et al.   CELL

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells

(2012) D. Z. Korta et al.   DEVELOPMENT

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

(2012) David Vilchez et al.   NATURE

A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad

(2012) Y. Shen et al.   SCIENCE

Genome-Wide Analysis of Germline Signaling Genes Regulating Longevity and Innate Immunity in the Nematode Pristionchus pacificus

(2012) Robbie Rae et al.   PLoS Pathogens

New genes that extend Caenorhabditis elegans’ lifespan in response to reproductive signals

(2011) Mark McCormick et al.   AGING CELL

Loss of intestinal nuclei and intestinal integrity in aging C. elegans

(2011) Matthew D. McGee et al.   AGING CELL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegans

(2011) Louis R. Lapierre et al.   CURRENT BIOLOGY

A Comprehensive Analysis of Gene Expression Changes Provoked by Bacterial and Fungal Infection in C. elegans

(2011) Ilka Engelmann et al.   PLoS One

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

(2011) Jérôme Goudeau et al.   PLOS BIOLOGY

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

(2011) Matthew J. Youngman et al.   PLoS Genetics

A pathway that links reproductive status to lifespan in Caenorhabditis elegans

(2010) Cynthia Kenyon   Annals of the New York Academy of Sciences

DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

(2010) Kelvin Yen et al.   ANTIOXIDANTS & REDOX SIGNALING

Insulin signaling promotes germline proliferation in C. elegans

(2010) D. Michaelson et al.   DEVELOPMENT

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

C. elegans Mutant Identification with a One-Step Whole-Genome-Sequencing and SNP Mapping Strategy

(2010) Maria Doitsidou et al.   PLoS One

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

(2010) Tracy M. Yamawaki et al.   PLOS BIOLOGY

Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans

(2010) Robert P. Shivers et al.   PLoS Genetics

The Caenorhabditis elegans Germ Line Regulates Distinct Signaling Pathways to Control Lifespan and Innate Immunity

(2009) Scott Alper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis

(2009) Olivier Zugasti et al.   NATURE IMMUNOLOGY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transcription Elongation Factor That Links Signals from the Reproductive System to Lifespan Extension in Caenorhabditis elegans

(2009) Arjumand Ghazi et al.   PLoS Genetics

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

The DAF-2 insulin-like signaling pathway independently regulates aging and immunity inC. elegans

(2008) Eric A. Evans et al.   AGING CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Distinct Innate Immune Responses to Infection and Wounding in the C. elegans Epidermis

(2008) Nathalie Pujol et al.   CURRENT BIOLOGY

Distinct Activities of the Germline and Somatic Reproductive Tissues in the Regulation of Caenorhabditis elegans ' Longevity

(2008) Tracy M. Yamawaki et al.   GENETICS

DAF-16-Dependent Suppression of Immunity During Reproduction in Caenorhabditis elegans

(2008) S. Miyata et al.   GENETICS

Specificity of the innate immune system and diversity of C-type lectin domain (CTLD) proteins in the nematode Caenorhabditis elegans

(2008) Hinrich Schulenburg et al.   IMMUNOBIOLOGY

Neuroendocrine signals modulate the innate immunity of Caenorhabditis elegans through insulin signaling

(2008) Trupti Kawli et al.   NATURE IMMUNOLOGY

Drosophila germ-line modulation of insulin signaling and lifespan

(2008) T. Flatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans

(2008) M. C. Wang et al.   SCIENCE