期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 19, 页码 4071-4076出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500565
关键词
Synthetic methods; Fluorine; Organofluorine compounds; Organosilicon compounds; Cyclopropanes; Carbocations
资金
- National Science Foundation (NSF) (CAREER) [CHE-0847262]
- Stonehill College
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0847262] Funding Source: National Science Foundation
A simple, high yielding, two-step, one-pot protocol for the preparation of trifluoromethyl-substituted vinylcyclopropanes from -CF3 homoallyl alcohols is disclosed. Destabilization of the cationic intermediate by the electron-withdrawing CF3 group greatly enhances neighboring group participation of the alkene, allowing ring closure to predominate. The reaction can be extended to the difluoromethyl and pentafluoroethyl group, enabling the preparation of a diverse array of fluoroalkyl-substituted vinylcyclopropanes.
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