Neuroscience in the third dimension: shedding new light on the brain with tissue clearing

Generation of Storable Retinal Organoids and Retinal Pigmented Epithelium from Adherent Human iPS Cells in Xeno-Free and Feeder-Free Conditions

(2017) Sacha Reichman et al.   STEM CELLS

Diverse Central Projection Patterns of Retinal Ganglion Cells

(2017) Emily M. Martersteck et al.   Cell Reports

Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline

(2017) Quentin Welniarz et al.   Scientific Reports

Recurrent DCC gene losses during bird evolution

(2017) François Friocourt et al.   Scientific Reports

Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences

(2016) Li Ye et al.   CELL

Multiplexed Intact-Tissue Transcriptional Analysis at Cellular Resolution

(2016) Emily Lauren Sylwestrak et al.   CELL

Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes

(2016) Nicolas Renier et al.   CELL

Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains

(2016) Filippo Casoni et al.   DEVELOPMENT

Three-dimensional microscopic analysis of clinical prostate specimens

(2016) Martin E van Royen et al.   HISTOPATHOLOGY

Fully Automated Evaluation of Total Glomerular Number and Capillary Tuft Size in Nephritic Kidneys Using Lightsheet Microscopy

(2016) Anika Klingberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Clearing and Labeling Techniques for Large-Scale Biological Tissues

(2016) Jinyoung Seo et al.   MOLECULES AND CELLS

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

(2016) Chenchen Pan et al.   NATURE METHODS

A survey of clearing techniques for 3D imaging of tissues with special reference to connective tissue

(2016) Adriano Azaripour et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny

(2016) Felicity M. Davis et al.   Nature Communications

ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging

(2016) Eunsoo Lee et al.   Scientific Reports

Clarifying Tissue Clearing

(2015) Douglas S. Richardson et al.   CELL

Intact-Brain Analyses Reveal Distinct Information Carried by SNc Dopamine Subcircuits

(2015) Talia N. Lerner et al.   CELL

Efficient processing and analysis of large-scale light-sheet microscopy data

(2015) Fernando Amat et al.   Nature Protocols

Stochastic electrotransport selectively enhances the transport of highly electromobile molecules

(2015) Sung-Yon Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A versatile clearing agent for multi-modal brain imaging

(2015) Irene Costantini et al.   Scientific Reports

Fast immuno-labeling by electrophoretically driven infiltration for intact tissue imaging

(2015) Jun Li et al.   Scientific Reports

Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass

(2015) William Menegas et al.   eLife

Whole-Brain Imaging with Single-Cell Resolution Using Chemical Cocktails and Computational Analysis

(2014) Etsuo A. Susaki et al.   CELL

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing

(2014) Bin Yang et al.   CELL

iDISCO: A Simple, Rapid Method to Immunolabel Large Tissue Samples for Volume Imaging

(2014) Nicolas Renier et al.   CELL

Simplified method to perform CLARITY imaging

(2014) Ekaterina Poguzhelskaya et al.   Molecular Neurodegeneration

Advanced CLARITY for rapid and high-resolution imaging of intact tissues

(2014) Raju Tomer et al.   Nature Protocols

Parasympathetic ganglia derive from Schwann cell precursors

(2014) I. Espinosa-Medina et al.   SCIENCE

A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System

(2014) Morgane Belle et al.   Cell Reports

High-Resolution, 2- and 3-Dimensional Imaging of Uncut, Unembedded Tissue Biopsy Samples

(2013) Richard Torres et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Structural and molecular interrogation of intact biological systems

(2013) Kwanghun Chung et al.   NATURE

CLARITY for mapping the nervous system

(2013) Kwanghun Chung et al.   NATURE METHODS

SeeDB: a simple and morphology-preserving optical clearing agent for neuronal circuit reconstruction

(2013) Meng-Tsen Ke et al.   NATURE NEUROSCIENCE

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Chemical Clearing and Dehydration of GFP Expressing Mouse Brains

(2012) Klaus Becker et al.   PLoS One

Assessment of Net Charge and Protein–Protein Interactions of Different Monoclonal Antibodies

(2011) Christian Lehermayr et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Three-dimensional imaging of the unsectioned adult spinal cord to assess axon regeneration and glial responses after injury

(2011) Ali Ertürk et al.   NATURE MEDICINE

Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain

(2011) Hiroshi Hama et al.   NATURE NEUROSCIENCE