期刊
JOURNAL OF SAUDI CHEMICAL SOCIETY
卷 21, 期 3, 页码 306-314出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jscs.2015.08.001
关键词
Multi-component reaction; Ionic liquid; Molecular docking; ADMET properties
资金
- CSIR, New Delhi, India [09/922 (0005) 2012/ EMR-I]
A series of novel chromeno-pyrazolo[1,2-b] phthalazine-6,9,14(7H)-trione derivatives (4a-k) were designed and prepared using a reusable and efficient catalyst ionic liquid [Bmim] BF4 via one-pot multi-component reaction. Their bioactivity was evaluated against Aspergillus niger and Candida albicans in vitro. Compound 4f was found to be the most effective compared to all other synthesised compounds. To validate experimental biological data obtained, molecular docking study was carried out. It was observed that compound 4f showed stronger binding interactions with secreted aspartic proteinase (SAP) of C. albicans (1EAG). Further, primary optimisation of drug-like properties was studied through in silico predictions by using ADMET predictor FAF-drug2 and OSIRIS property explorer. (C) 2015 King Saud University. Production and hosting by Elsevier B.V.
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