期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 25, 页码 5594-5602出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500855
关键词
Iron; Dealkylation; Acylation; Sulfoximines; Alkylation
资金
- Alexander von Humboldt Foundation for a postdoctoral fellowship
As a result of our recent investigations into the N-functionalization of sulfoximines, an iron-catalyzed dealkylative acylation of N-alkylsulfoximines has been developed. This process involves a Polonovski-type dealkylation of an N-alkylated sulfoximine to afford a reactive intermediate that is trapped in the presence of a suitable aldehyde or anhydride to afford N-acyl- and N-aroylsulfoximine derivatives in one pot. Subsequent cleavage of the acyl or aroyl group under acidic conditions generates a synthetically valuable NH-sulfoximine.
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