期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 7, 页码 1606-1612出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201403499
关键词
Homogeneous catalysis; Copper; Radical reactions; Azo compounds; Cyclization; Cyanides
资金
- National Natural Science Foundation of China (NSFC) [21462017, 21372251]
- China Postdoctoral Science Foundation [2014M50649]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
A practical copper-catalysed oxidative radical alkylarylation of activated alkenes using AIBN (azobisisobutyronitrile) and related reagents has been developed. This has allowed the general incorporation of nitrile moieties into oxindoles by a cascade addition/C(sp(2))-H cyclization process. This protocol demonstrates for the first time that DIAD (diisopropyl azodicarboxylate) can act as a new activator for the C(sp(3))-H functionalization of acetonitrile instead of the usual Ag salts. The use of an inexpensive copper salt as the catalyst, the general access to primary and tertiary nitriles, as well as the air-and moisture-tolerant reaction conditions make this protocol a highly attractive approach to cyano-containing oxindoles.
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