Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through the Primary Amine-Catalyzed Michael Addition Reaction of α-Substituted Cyclic Ketones at High Pressure

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

(2015) Yiyang Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Unified Strategy to Monoterpene Indole Alkaloids: Total Syntheses of (±)-Goniomitine, (±)-1,2-Dehydroaspidospermidine, (±)-Aspidospermidine, (±)-Vincadifformine, and (±)-Kopsihainanine A

(2014) Olivier Wagnières et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric organocatalytic desymmetrization of 4,4-disubstituted cyclohexadienones at high pressure: a new powerful strategy for the synthesis of highly congested chiral cyclohexenones

(2014) Naomu Miyamae et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Pd(II)-Catalyzed One-Step Construction of Cycloalkane-Fused Indoles and Its Application in Formal Synthesis of (±)-Aspidospermidine

(2014) Guoqin Xia et al.   ORGANIC LETTERS

Enantioselective Palladium-Catalyzed Decarboxylative Allylation of Carbazolones: Total Synthesis of (−)-Aspidospermidine and (+)-Kopsihainanine A

(2013) Zeqian Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Construction of All-Carbon Quaternary Stereocenters by Use of Pd-Catalyzed Asymmetric Allylic Alkylation Reactions in Total Synthesis

(2013) Allen Y. Hong et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Efficient Organocatalytic Michael Addition Reaction of β−Ketoesters under High Pressure

(2013) Hiyoshizo Kotsuki et al.   HETEROCYCLES

Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters

(2013) Lindsay M. Repka et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of a Chiral Quaternary Carbon Center by Catalytic Asymmetric Alkylation of 2-Arylcyclohexanones under Phase-Transfer Conditions

(2013) Taichi Kano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Domino Michael/Mannich/N-Alkylation Route to the Tetrahydrocarbazole Framework of Aspidosperma Alkaloids: Concise Total Syntheses of (−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine

(2013) Senzhi Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formal Synthesis of Aspidospermidine via the Intramolecular Cascade Transannular Cyclization

(2013) Yu-Rong Yang et al.   SYNLETT

Enantiospecific total synthesis of indole alkaloids (+)-eburnamonine, (−)-aspidospermidine and (−)-quebrachamine

(2013) John Eugene Nidhiry et al.   TETRAHEDRON

Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

(2012) Lindsay McMurray et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Inter- and Intramolecular Formal [4+2] Cycloaddition of Cyclobutanones with Indoles and Total Synthesis of (±)-Aspidospermidine

(2012) Mizuki Kawano et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

(2012) Renato Dalpozzo et al.   CHEMICAL SOCIETY REVIEWS

High pressure promoted aza-Michael addition of primary and secondary amines to α-substituted acrylates

(2012) Alexander Yu. Rulev et al.   GREEN CHEMISTRY

Pd(II)-Catalyzed Regioselective 2-Alkylation of Indoles via a Norbornene-Mediated C–H Activation: Mechanism and Applications

(2012) Lei Jiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Primary Amine, Thiourea-Based Dual Catalysis Motif for Synthesis of Stereogenic, All-Carbon Quaternary Center-Containing Cycloalkanones

(2012) Jun Yong Kang et al.   ORGANIC LETTERS

Highly Efficient Asymmetric Michael Addition Reaction of Malonates to α,β-Unsaturated Ketones Promoted by a Chiral Thiourea/PPY Dual-Catalyst System

(2012) Hiyoshizo Kotsuki et al.   SYNLETT

Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy

(2011) Baomin Wang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective synthesis of all-carbon quaternary stereogenic centers in acyclic systems

(2011) Jaya Prakash Das et al.   CHEMICAL COMMUNICATIONS

Enantioselective Decarboxylative Alkylation Reactions: Catalyst Development, Substrate Scope, and Mechanistic Studies

(2011) Douglas C. Behenna et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric aza-Michael addition under ultra-high pressure: short bias to polyhydroxylated piperidines

(2011) Sidnei Moura et al.   GREEN CHEMISTRY

Collective synthesis of natural products by means of organocascade catalysis

(2011) Spencer B. Jones et al.   NATURE

Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine

(2010) Filippo De Simone et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of (±)-Aspidospermidine Starting from 3-Ethyl-5-bromo-2-pyrone

(2010) Hyun-Kyu Cho et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Direct Access to Cumbersome Aminated Quaternary Centers by Hyperbaric Aza-Michael Additions

(2010) Alexander Yu. Rulev et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis of (−)-Mersicarpine

(2010) Rie Nakajima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Powerful Strategy for the Organocatalytic Asymmetric Construction of a Quaternary Carbon Stereogenic Center

(2010) Yogo Inokoishi et al.   ORGANIC LETTERS