Article
Chemistry, Multidisciplinary
Shmuel Einy, Gal Michaeli-Geller, Dror Aizenbud
Summary: This study aims to present conservative treatment approaches for impacted teeth caused by supernumerary teeth and odontomas. Three treatment modalities are reviewed, including surgery only, surgery with immediate traction, and surgery with delayed traction. Clinical follow-up and active orthodontic traction can promote the process of tooth eruption.
APPLIED SCIENCES-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Sha Su, Chang Liu, Yuheng Zhang, Jiaman Zhu, Weilong Ye, Runtao Gao
Summary: The study found through CBCT image analysis that the main internal force of anterior border absorption of the mandibular ramus was the pressure during tooth development, and the release of pressure after tooth eruption may be a possible reason for the occurrence of supernumerary teeth.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Piranit Nik Kantaputra, Kanich Tripuwabhrut, Robert P. Anthonappa, Kanoknart Chintakanon, Chumpol Ngamphiw, Ploy Adisornkanj, Nop Porntrakulseree, Bjorn Olsen, Worrachet Intachai, Raoul C. Hennekam, Alexandre R. Vieira, Sissades Tongsima
Summary: This study aimed to investigate the genetic etiology of extra tooth phenotypes, including mesiodens and isolated supernumerary teeth. Through oral and radiographic examinations and whole-exome sequencing, seven out of eight patients were identified with heterozygous missense variants in FREM2. These findings suggest that mutations in FREM2 are associated with extra tooth phenotypes.
Article
Biochemistry & Molecular Biology
Chomchanok Panyarat, Siriruk Nakornchai, Kanoknart Chintakanon, Niramol Leelaadisorn, Worrachet Intachai, Bjorn Olsen, Sissades Tongsima, Ploy Adisornkanj, Chumpol Ngamphiw, Timothy C. Cox, Piranit Kantaputra
Summary: The activation of Wnt/beta-catenin signalling is essential for tooth development. APC, a component of the AXIN-CK1-GSK3 beta-APC beta-catenin destruction complex, regulates Wnt/beta-catenin signalling to establish normal tooth number and position. Loss-of-function mutations in APC result in over-activation of WNT/beta-catenin signalling and can cause familial adenomatous polyposis (FAP) and supernumerary teeth. In this study, rare genetic variants in APC were identified in patients with supernumerary teeth phenotypes, suggesting a contribution of APC to isolated supernumerary dental abnormalities such as mesiodens and isolated supernumerary premolar.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Chun-Yuh Huang, Daniela M. Loo, Weiyong Gu
Summary: Loss of proteoglycan (PG) is a potential factor responsible for intervertebral disc (IVD) degeneration. A new mathematical model of GAG biosynthesis was developed for IVD cells, showing that glycolytic enzymes significantly enhance GAG biosynthesis, especially under low glucose supply. Increasing intracellular glutamine concentration or the activity of glutamine:fructose-6-phosphate amidotransferase in the hexamine pathway also promotes GAG biosynthesis. This study enhances our understanding of the relationship between glycolysis and PG biosynthesis in IVD cells and provides a theoretical framework for developing new preventive and treatment strategies for IVD degeneration.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
John R. Couchman
Summary: Cell surface proteoglycans, such as syndecans, play crucial roles in regulating cell behavior, including interactions with extracellular matrix components and mediating proliferation, adhesion, and migration. In tumors, changes in the levels and distribution of syndecan-1 can have implications for prognosis, with loss of membrane staining and abnormal cytoplasmic or nuclear staining often indicating poor outcomes. Targeting syndecan-1 with antibody-toxin conjugates may hold promise for clinical applications in both myeloma and some carcinomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandra Y. Tsidulko, Oleg B. Shevelev, Anna S. Khotskina, Mariia A. Kolpakova, Anastasia Suhovskih, Galina M. Kazanskaya, Alexander M. Volkov, Svetlana Aidagulova, Evgenii L. Zavyalov, Elvira Grigorieva
Summary: The study found that changes induced by systemic chemotherapy in the glycosylated components of brain extracellular matrix can impact the fate of residual glioblastoma cells and contribute to glioblastoma relapse. Therefore, ECM-targeted therapy may be a useful strategy to mitigate the negative effects of adjuvant treatment on glioblastoma patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Delfien Syx, Sarah Delbaere, Catherine Bui, Adelbert De Clercq, Goran Larson, Shuji Mizumoto, Tomoki Kosho, Sylvie Fournel-Gigleux, Fransiska Malfait
Summary: Proteoglycans, consisting of a core protein and glycosaminoglycan chains, play versatile functions in physiological and pathological processes. The biosynthesis of glycosaminoglycan chains is a complex process involving various enzymes. Deficiencies in these biosynthetic enzymes can lead to severe disorders, such as the Ehlers-Danlos syndromes. This review summarizes the consequences of glycosaminoglycan deficiency in specific types of Ehlers-Danlos syndromes and provides insights into the underlying pathophysiological mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Surgery
Sacide Duman, Handan Vural, Suayip Burak Duman
Summary: This study compared the radiographic development of permanent teeth in children with and without supernumerary teeth (ST), finding that children with ST had higher DA values than CA values. Panoramic radiography was found to be adequate for determining dental development using the Demirjian method.
JOURNAL OF CRANIOFACIAL SURGERY
(2021)
Review
Orthopedics
K. S. Emanuel, L. J. Kellner, M. J. M. Peters, M. J. J. Haartmans, M. T. Hooijmans, P. J. Emans
Summary: This study aims to establish the relationship between quantitative magnetic resonance imaging (MRI) and biochemical concentration and organization in knee articular cartilage. The results show a significant correlation between delayed gadolinium-enhanced MRI of cartilage and proteoglycan concentration, while no correlation was found between T2 relaxation times and collagen concentration, but rather with organization.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Weihan Hua, Ziqi Gan, Yeke Wu, Lixing Zhao
Summary: In this study, a novel heterozygous mutation in the FER1L6 gene was identified as a potential cause of non-syndromic familial multiple supernumerary teeth through genetic analysis.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Celine Stutz, Francois Clauss, Olivier Huck, Georg Schulz, Nadia Benkirane-Jessel, Fabien Bornert, Sabine Kuchler-Bopp, Marion Strub
Summary: The use of a PCL membrane can prevent ankylosis when implanting bioengineered teeth and promote spontaneous eruption. This study describes a new method that improves the success rate of bioengineered teeth in the jawbone of adult mice.
Review
Biochemistry & Molecular Biology
Zheng Fang, Devi Atukorallaya
Summary: Tooth number anomalies are common congenital dental problems, and the precise number of teeth is crucial for proper function and aesthetics. This article proposes a regulatory network for tooth number based on the dentition formation process and summarizes recent studies on early tooth development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
S. M. Ziauddin, Misako Nakashima, Hideto Watanabe, Michiyo Tominaga, Koichiro Iohara
Summary: This study compared the stem cell properties and pulp regenerative potential of DT-DPSCs and PT-DPSCs from the same individual. The results showed that DT-DPSCs exhibited higher expression of stem cell markers and angiogenic factors compared to PT-DPSCs. DT-DPSC-derived conditioned medium also promoted increased cell proliferation, migration, and angiogenesis. Furthermore, the regenerated pulp tissues in both DT-DPSCs and PT-DPSCs groups were similar. Therefore, DT-DPSCs could be a potential alternative to PT-DPSCs for pulp regenerative therapy.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Dentistry, Oral Surgery & Medicine
Rei Chiel Yap, Meshal Alghanem, Nicolas Martin
Summary: Cracks in teeth are a common clinical finding, but clinicians still struggle to identify the full extent and orientation of cracks for appropriate management. The biomechanics of crack development can differ between unrestored teeth and restored or endodontically treated teeth.
JOURNAL OF DENTISTRY
(2023)
Article
Anatomy & Morphology
Kaoru Fujikawa, Naoko Nonaka, Xiaofang Wang, Shunichi Shibata
Summary: The expression patterns of syndecan-1, 2, 3, and 4 mRNAs during late tooth germ formation were investigated. Syndecan-1 mRNA was mainly expressed in specific tooth germ regions and its expression in dental epithelium increased during the postnatal periods. Syndecan-3 mRNA was found to be involved in dentinogenesis, while syndecan-2 showed enhanced expression with hard tissue formation. Syndecan-4 exhibited similar expression patterns to syndecan-3.
ANATOMICAL SCIENCE INTERNATIONAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yiruo He, Yangyang Wang, Xinghai Wang, Jiangyue Wang, Ding Bai, Yongwen Guo
Summary: This case report presents the successful nonsurgical treatment of a 20-year-old male patient with hyperdivergent skeletal Class III malocclusion. Using miniscrews and other auxiliary tools, proper occlusion and improved facial profile were achieved.
ANGLE ORTHODONTIST
(2022)
Review
Cell & Tissue Engineering
Lingyi Huang, Zizhuo Zheng, Ding Bai, Xianglong Han
Summary: This article summarizes the biological characteristics of stem cells from human exfoliated deciduous teeth (SHEDs) and their potential role in the prevention and treatment of neurological diseases and injuries.
CURRENT STEM CELL RESEARCH & THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ye Tian, Gao Huang, Xiang Xiang, Ning Wang, Wenyu Dai, Jiajun Chen, Rui Shu, Ding Bai, Hui Xu
Summary: This study identified the key parameter for the positioning of anterior teeth in 45 degrees angled smiles through 3-dimensional facial image processing and geometric analysis. It provides an important reference for esthetic assessment and establishes esthetic ranges for different observers.
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2022)
Article
Endocrinology & Metabolism
Zhongyu Liu, Yijia Yin, Zheng Wang, Liang Xie, Peng Deng, Donghui Wang, Ning Ji, Hang Zhao, Xianglong Han, Qianming Chen, Chun-Hsi Chung, Ding Bai, Xuefeng Zhao
Summary: Fibrous dysplasia (FD) is a rare bone disease caused by GNAS mutation, and there is currently no cure available. Inhibition of RANKL expression has been identified as a potential therapy for FD. This study evaluated the effects of a small-molecule RANKL inhibitor (A52676293) on a transgenic FD mouse model, and found that it effectively suppressed osteoclastogenesis and halted FD progression. The results suggest that RANKL inhibition could be an effective treatment for FD.
Article
Biochemistry & Molecular Biology
Yiruo He, Ye Tian, Wenjie Zhang, Xinghai Wang, Xue Yang, Bin Li, Liming Ge, Ding Bai, Defu Li
Summary: The oxidized sodium alginate (OSA) collagen heterogeneous bilayer barrier membrane with well-controlled pore size presents a significant improvement in promoting osteogenesis and enhancing barrier function, showing important implications for bone regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Jiangyue Wang, Sa Cha, Qing Zhao, Ding Bai
Summary: This systematic review aimed to explore the diagnostic accuracy of CBCT and ultrasound for gingival thickness measurement. The results showed no significant difference between CBCT measurement and transgingival probing in both anterior and posterior dentition. A moderate correlation was observed between CBCT and transgingival probing, while a weak correlation was found between ultrasound measurement and transgingival probing.
JOURNAL OF ESTHETIC AND RESTORATIVE DENTISTRY
(2022)
Article
Engineering, Biomedical
Yi Deng, Jiacheng Shi, Yau Kei Chan, Ding Bai, Rui Shu, Xiuyuan Shi, Yunfei Li, Limei Li, Xiao Yang, Weizhong Yang
Summary: In this study, a heterostructured coating was created on a porous bioinert polyetheretherketone implant. The heterostructured coating significantly promotes cytocompatibility and osteogenic differentiation through multiple mechanisms and effectively kills bacteria through photothermal/photodynamic effects and photo-induced accelerated ion release. The results confirmed the excellent osteogenicity and osseointegration of the heterostructured orthopedic implant, as well as its photoswitchable disinfection controlled by NIR light.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yipeng Wang, Peiqi Wang, Xiang Xiang, Hui Xu, Yuting Tang, Yumeng Zhou, Ding Bai, Chaoran Xue
Summary: The study proposed a standardized protocol for 3D-printed splints and assessed the precision of splints with different occlusal coverage depths. Results showed that deviations were more evident in the vertical dimension and pitch rotation, increasing as the occlusal coverage depth increased. Splints with 2-mm and 3-mm occlusal coverage depths are recommended for precision relative to clinical acceptability.
Article
Cell Biology
Xin Fang, Nan Ni, Xiaofang Wang, Yanan Tian, Ivan Ivanov, Monique Rijnkels, Kayla J. Bayless, John P. Lydon, Qinglei Li
Summary: EZH2 has dual roles in the development of endometrial cancer, functioning as an oncogene in the early stages but also leading to unfavorable outcomes during disease progression, characterized by exacerbated epithelial stratification and heightened inflammatory response.
Article
Biochemistry & Molecular Biology
Changchun Dong, Bikash Lamichhane, Hajime Yamazaki, Brent Vasquez, Jingya Wang, Yongxu Zhang, Jian Q. Feng, Henry C. Margolis, Elia Beniash, Xiaofang Wang
Summary: This study generated two lines of Enam knock-in mice using the CRISPR-Cas9 method to eliminate or mimic the phosphorylation state of Ser(55) in ENAM. The results showed that Ser(55) phosphorylation is essential for ENAM function during enamel formation.
Article
Biology
Bhaba K. Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J. Krager, Renny Lan, Samuel G. Mackintosh, Ricky Edmondson, Michael L. Jennings, Xiaofang Wang, Jian Q. Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao
Summary: Increased intracellular iron through Tfr1-mediated iron uptake is essential for mitochondrial metabolism and cytoskeletal organization in osteoclasts, leading to proper bone resorption and skeletal homeostasis.
Article
Biochemistry & Molecular Biology
Zheng Wang, Chi Ma, Diane Chen, Caitlin Haslett, Chunmei Xu, Changchun Dong, Xiaofang Wang, Minghao Zheng, Yan Jing, Jian Q. Feng
Summary: This study reveals that tendon cells directly form fibrocartilage through cell transdifferentiation, shedding light on the mechanisms underlying enthesopathy and sporting injuries.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Zhang Yanli, Mo Jiayao, Zheng Chunqing, Zeng Yuting, Zhou Zhiyan, Zhang Yulin, Li Minghan, Shao Longquan, Yang Dehong, Yan Wenjuan
Summary: The dynamic changing of extracellular matrix (ECM) can activate the driving force of osteoblast cells and accelerate bone regeneration. In this study, a novel peptide MY-1 is designed and synthesized, and nano-hydroxyapatite (nHA) is used as the carrier for sustained release of MY-1. The results show that sustained release of MY-1 regulates the synthesis and secretion of ECM, promoting cell migration and osteogenic differentiation, which benefits bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wenhao Ruan, Ziting Zheng, Lifang Jiang, Jiahui He, Jieli Sun, Wenjuan Yan
Summary: This study evaluated the stress distribution patterns, resistance to fracture, and failure modes of endodontically treated molars restored with different cuspal coverage options. The results showed that onlay restorations with whole functional cuspal coverage provided comparable effects to coverage of all cusps in terms of stress distribution, fracture resistance, and mechanical performance in high occlusal areas.
INTERNATIONAL JOURNAL OF COMPUTERIZED DENTISTRY
(2022)