Article
Environmental Sciences
Min Zhang, Yan-Ling Deng, Chong Liu, Pan-Pan Chen, Qiong Luo, Yu Miao, Fei-Peng Cui, Long-Qiang Wang, Ming Jiang, Qiang Zeng
Summary: This study examined the associations between phthalate exposures and thyroid function, as well as the potential mediating role of oxidative stress, among patients with thyroid nodules. The results showed that certain phthalate metabolites were linked to altered thyroid function and increased oxidative stress biomarkers. Additionally, lipid peroxidation may serve as an intermediate mechanism in the effects of phthalate exposures on thyroid function among patients with benign thyroid nodules.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
Ceyhun Bereketoglu, Ajay Pradhan
Summary: This review investigates the effects of plasticizers on the thyroid system of animals and humans, revealing that plasticizers could alter thyroid function and lead to various medical problems.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Andrea Rodriguez-Carrillo, Elena Salamanca-Fernandez, Elly den Hond, Veerle J. Verheyen, Lucia Fabelova, Lubica Palkovicova Murinova, Susana Pedraza-Diaz, Argelia Castano, Jose Vicente Garcia-Lario, Sylvie Remy, Eva Govarts, Greet Schoeters, Nicolas Olea, Carmen Freire, Mariana F. Fernandez
Summary: This study investigated the association between exposure to PFAS and phthalates and serum levels of thyroid hormones in European adolescents, and found sex-specific differences in the effects.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Han-Bin Huang, Chi-Ying Siao, Yuan-Ting C. Lo, Shu-Fang Shih, Chieh-Hua Lu, Po-Chin Huang
Summary: This study investigated the mediating influence of thyroid hormone levels on the association between phthalate exposure and insulin resistance. Results indicated that thyroid function plays a crucial mediating role in the relationship between phthalate exposure and glucose metabolism.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Ophelie Coiffier, Dorothy Nakiwala, Matthieu Rolland, Andres Malatesta, Sarah Lyon-Caen, Benoit Chovelon, Patrice Faure, Anne Sophie Gauchez, Dorra Guergour, Amrit K. Sakhi, Azemira Sabaredzovic, Cathrine Thomsen, Isabelle Pin, Remy Slama, Christelle Corne, Claire Philippat
Summary: This study aimed to assess the effects of non-persistent environmental chemicals on neonatal thyroid hormones and found that prenatal exposure to certain phenols and phthalates can disrupt thyroid hormone homeostasis at birth. Additionally, the effects of these chemicals on thyroid hormones were found to be modified by the child's sex.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Catheryne Chiang, Diana C. Pacyga, Rita S. Strakovsky, Rebecca L. Smith, Tamarra James-Todd, Paige L. Williams, Russ Hauser, Daryl D. Meling, Zhong Li, Jodi A. Flaws
Summary: This study found that there are positive associations between phthalate exposure and hormone levels in midlife women, especially affecting reproductive hormones, but the specific mechanisms are still unclear. Exposure to phthalates may have adverse effects on ovarian function, leading to changes in hormone levels, particularly estrogen, progesterone, and others.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Giehae Choi, Gro D. Villanger, Samantha S. M. Drover, Amrit K. Sakhi, Cathrine Thomsen, Rachel C. Nethery, Pal Zeiner, Gun Peggy Knudsen, Ted Reichborn-Kjennerud, Kristin R. Overgaard, Amy H. Herring, Annette H. Skogan, Guido Biele, Heidi Aase, Stephanie M. Engel
Summary: The study evaluated the relationship between prenatal phthalate exposure and preschool-aged children's executive function (EF), finding that children exposed to MBzP, MiBP, and MnBP during pregnancy exhibited poorer EF profiles across a range of instruments and raters, with more pronounced effects in boys.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Jieyu Liu, Di Gao, Huan Wang, Yanhui Li, Manman Chen, Qi Ma, Xinxin Wang, Mengjie Cui, Li Chen, Yi Zhang, Tongjun Guo, Wen Yuan, Tao Ma, Jianuo Jiang, Yanhui Dong, Zhiyong Zou, Jun Ma
Summary: This study in Chinese children found that long-term exposure to phthalate esters (PAEs) was associated with increased femininity trait scores in boys with early puberty onset. Additionally, persistent exposure to low molecular weight phthalates (LMWP) was negatively associated with undifferentiated gender identity in some boys.
ENVIRONMENTAL HEALTH
(2023)
Article
Environmental Sciences
Carolina Donat-Vargas, Francisco Perez-Carrascosa, Celia Gomez-Pena, Vicente Mustieles, Inmaculada Salcedo-Bellido, Hanne Frederiksen, Agneta Akesson, Juan Pedro Arrebola
Summary: This study explored the associations between phthalate metabolites and thyroid function indicators in adults, finding some metabolites positively associated with TT3 and FT4, and overall metabolite concentrations seem to be related to increased TT3 and FT4 serum levels. However, the cross-sectional nature of the analysis limits causal inference.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Huihua Yang, Yuming Zheng, Xuefeng Lai, Lei Zhao, Linlin Liu, Miao Liu, Wenting Guo, Liangle Yang, Qin Fang, Kejing Zhu, Wencan Dai, Wenhua Mei, Rui Zhu, Xiaomin Zhang
Summary: This study aimed to explore the associations of 10 urinary phthalate metabolites with thyroid function indicators among children. The results showed significant positive relationships between certain phthalate metabolites and thyroid-stimulating hormone or free thyroxine levels. Additionally, a mixture of these phthalate metabolites was found to be associated with elevated thyroid-stimulating hormone and free thyroxine levels, with mono-(2-ethylhexyl) phthalate and monobenzyl phthalate being major contributors. The study also identified IL-16 as a mediator of the relationships between certain phthalate metabolites and thyroid-stimulating hormone levels.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Yuan Zheng, Longman Li, Hong Cheng, Shengzhu Huang, Xiuming Feng, Lulu Huang, Luyun Wei, Dehao Cao, Sida Wang, Long Tian, Weijun Tang, Caitong He, Chunhua Shen, Bangzhu Luo, Maoling Zhu, Tao Liang, Baohong Pang, Mujun Li, Chaoqun Liu, Xing Chen, Fei Wang, Zengnan Mo, Xiaobo Yang
Summary: The study found that boys may be more vulnerable to the neurotoxic effects of phthalates, particularly mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP) which has adverse effects on boys' gross motor skills. Adverse effects of phthalates on children's neurodevelopment were also discovered in the 1st and 2nd trimesters. Therefore, supplementing appropriate elements during these periods may help reduce the detrimental effects of phthalates on children's neurodevelopment, especially among boys.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Christian H. Lindh, Robin P. Peeters, Andreas Kortenkamp, Barbara Demeneix, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: The study found that elevated levels of certain phthalate metabolites in maternal urine during pregnancy may be associated with abnormalities in thyroid system markers. These results are in line with findings from experimental studies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Bernard Robaire, Geraldine Delbes, Jessica A. Head, Vicki L. Marlatt, Christopher J. Martyniuk, Stephane Reynaud, Vance L. Trudeau, Jan A. Mennigen
Summary: Studies have mainly focused on the effects of EDCs on adult males and females, but exposure of mature or developing gametes can lead to multigenerational and transgenerational effects. By synthesizing knowledge across vertebrate species, potential mechanisms of EDC effects are discussed, and recommendations for advancing the field are proposed.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Yuhan Zhou, Pengpeng Wang, Jiufeng Li, Yingya Zhao, Yanran Huang, Kelvin Sze-Yin Leung, Huijing Shi, Yunhui Zhang
Summary: This study examined the effects of mixed exposure to phthalates and UV filters on pubertal development in school-age children. The results showed that higher levels of phthalate metabolites and UV filters were associated with delayed pubertal development in boys but with earlier puberty in girls. The study also found that the joint exposure of phthalates and UV filters had a larger effect size on pubertal development compared to single chemicals.
Article
Environmental Sciences
Iman Al-Saleh
Summary: The study suggests that DEHP may contribute to PCOS, but further investigation is needed to understand the underlying mechanisms.
Article
Medicine, General & Internal
Sung-Ching Pan, Mu-Ching Hsu, Hsin-Hsin Chang, Jann-Tay Wang, Yu-Ling Lai, Pau-Chung Chen, Sui-Yuan Chang, Wang-Huei Sheng, Yee-Chun Chen, Shyr-Chyr Chen, Shan-Chwen Chang
Summary: This article describes a prospective health surveillance of HCP and COVID-19 containment measures in a teaching hospital in Taiwan, successfully preventing COVID-19 infections.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Public, Environmental & Occupational Health
Ping Shih, Ching-chun Huang, Tung-liang Chiang, Pau-Chung Chen, Yue Leon Guo
Summary: This study investigates the relationship between work-related mental stress during pregnancy and offspring ADHD. Among pregnant female workers, higher levels of job stress were found to be associated with a higher risk of ADHD in their children.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Chemistry, Analytical
Ju-Yu Chen, Guan-Yuan Chen, San-Yuan Wang, Cheng-Chung Fang, Lian-Yu Chen, Te- Weng
Summary: Analyzing emerging new psychoactive substances presents a significant risk to public health, highlighting the importance of developing specific analytical methods for these substances. This study refined a novel workflow using in-house tools to develop an MRM-based method, effectively identifying unique and selective MRM transitions, which was successfully applied to urine sample analysis, providing a new approach for method development in analyzing complex samples.
Article
Environmental Sciences
Wei-shan Chin, Shih-chun Pan, Ching-chun Huang, Yu-cheng Chen, Chin-yu Hsu, Pinpin Lin, Pau-chung Chen, Yue Leon Guo
Summary: This study found that individuals residing near petrochemical industrial parks (PIPs) have a higher risk of chronic glomerulonephritis (CGN), particularly those living within 10 kilometers of the PIPs. These findings highlight the importance of monitoring environmental nephrotoxic substances and the renal health of residents living near PIPs.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Hsiao-Lin Hwa, Fu-Shiang Peng, Te-Tien Ting, Huei-Wen Chen, Hsiang-Yu Chan, Da-Peng Yang, Pau-Chung Chen, Yun-Ning Kuo, Pai-Shan Chen
Summary: This study investigates the association between prenatal exposure to phthalates and birth outcomes in infants. The results suggest that certain phthalate metabolites are correlated with anogenital index and head circumference in male and female infants.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Plant Sciences
Chi-Jen Chen, Wei-Che Chiu, Yao-Hsien Tseng, Chien-Mu Lin, Hsiao-Yu Yang, Yao-Hsu Yang, Pau-Chung Chen
Summary: This study found an association between exposure to aristolochic acid (AA) and the risk of certain cancers. AA exposure may increase the risk of kidney, bladder, pelvis, ureter, liver, colorectal, prostate cancer in all patients, and extrahepatic bile duct cancer in women.
Article
Environmental Sciences
Chin-Yu Hsu, Pei-Yu Wu, Yu-Cheng Chen, Pau-Chung Chen, Yue Leon Guo, Yi-Jun Lin, Pinpin Lin
Summary: This study analyzed comprehensive measurement data of 109 VOCs collected from 17 monitoring stations around petrochemical industrial parks in Taiwan from 2015 to 2018. The results identified six VOCs, including 1,3-butadiene, benzene, 1,2-dichloroethane, chloroform, vinyl chloride, and acrylonitrile, with more than 50% of their emissions attributed to petrochemical industrial parks. This integrated approach can assist regulatory agencies in proposing effective control strategies to reduce the health risk associated with high-concern VOC emissions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Shih-Feng Chen, Yu-Hui Chien, Pau-Chung Chen
Summary: Long-term exposure to PM2.5 exceeding a threshold was found to be associated with increased risk of mortality among dialysis patients.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Tsung-Chien Lu, Chih-Hung Wang, Fan-Ya Chou, Jen-Tang Sun, Eric H. Chou, Edward Pei-Chuan Huang, Chu-Lin Tsai, Matthew Huei-Ming Ma, Cheng-Chung Fang, Chien-Hua Huang
Summary: Using machine learning, the study aimed to predict cardiac arrest in the emergency department based on triage data. The results showed that the machine learning models, particularly Random Forest, outperformed other models and the National Early Warning Score 2 in terms of predicting cardiac arrest. This approach has the potential to reduce unexpected resuscitation events in the emergency department.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Medicine, Legal
Tse-Hao Chen, Hsien-Yi Chen, Chih-Chuan Lin, Sung-Wei Liu, Te- Weng, Cheng-Chung Fang, Jiun-Hao Yu, Yen-Chia Chen, Yu-Jang Su
Summary: This study aimed to understand the clinical characteristics of NPS users presenting to the emergency department. The results showed that NPS users were younger, more likely to experience facial flush and palpitation, and more prone to self-harm, violence, and suicide compared to non-NPS drug users. Physicians should pay attention to patients with altered mental states and the described clinical characteristics.
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2023)
Article
Emergency Medicine
Dean-An Ling, Chih-Wei Sung, Cheng-Chung Fang, Chia-Hsin Ko, Eric H. Chou, Jeffrey Herrala, Tsung-Chien Lu, Chien-Hua Huang, Chu-Lin Tsai
Summary: This study aimed to investigate the incidence, trend, and factors associated with high-risk emergency department (ED) revisits. High-risk revisits accounted for a stable proportion of ED visits over the study period. Older age, Hispanic ethnicity, daytime visits, and arrival by ambulance were independent predictors of high-risk revisits.
WESTERN JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Chu-Lin Tsai, Ming-Tai Cheng, Shu-Hsien Hsu, Tsung-Chien Lu, Chien-Hua Huang, Yueh-Ping Liu, Chung-Liang Shih, Cheng-Chung Fang
Summary: This study used social network analysis to analyze the transfer network of EDs in Taiwan, finding a regionalized pattern with low density, moderate centralization, and high clustering. Understanding these network metrics helps in tracking the structure and process of regionalized healthcare.
SCIENTIFIC REPORTS
(2023)
Article
Construction & Building Technology
Po -Kai Chang, Hsiang-Hao Chuang, Ta-Chih Hsiao, Hsiao-Chi Chuang, Pau -Chung Chen
Summary: This study investigates the characteristics and transmission of pollutants in hospital operation rooms (ORs) through on-site measurements and numerical simulations. The results show that gaseous pollutants have lower air exchange rates (AERs) compared to particulate pollutants, and the AER of total volatile organic compounds (TVOC) is higher than that of carbon dioxide (CO2). The emission factors (EF) of surgical smoke particles vary depending on the surgical procedure. Coarse particles are primarily influenced by drag forces, resulting in lower AER values. Additionally, smaller particles exhibit lower AER values, potentially due to stronger Brownian motion. The combination of measurement and simulation analysis allows for the evaluation of lung deposited surface area (LDSA) concentrations, providing accurate exposure concentrations for health risk assessments.
BUILDING AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Summary: The currently used air quality index (AQI) is criticized for its inability to capture the additive effects of air pollution on health risks and reflect non-threshold concentration-response relationships. In this study, we propose the air quality health index (AQHI) based on daily air pollution-mortality associations and compare its validity in predicting daily mortality and morbidity risks with the existing AQI.
ENVIRONMENTAL RESEARCH
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Ping-Hui Chen, Chung-Yen Chen, Min-Han Tsai, Rodger Tsai, Hsiao-Yu Yang, Chen Pau-Chung
SAFETY AND HEALTH AT WORK
(2022)
