期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 14, 期 1, 页码 81-84出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2017.1386360
关键词
Staphylococcus aureus; capsular polysaccharide; vaccine; antibody response; O-acetylation
资金
- Pfizer
Staphylococcus aureus produces an antiphagocytic polysaccharide capsule to evade neutrophil-mediated killing. Many vaccines against encapsulated bacterial pathogens require generation of functional anti-capsular antibodies to mediate protection against infection and disease. Here it is shown that the generation of such antibody responses to S. aureus in vivo and in vitro requires the presence of O-acetyl modifications on the capsular polysaccharides. O-acetylation of S. aureus capsular polysaccharide therefore should be monitored carefully during vaccine development and production. This finding may provide additional insight into the previous failure of a S. aureus capsular polysaccharide conjugate vaccine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据