期刊
G3-GENES GENOMES GENETICS
卷 7, 期 3, 页码 823-834出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.116.037101
关键词
hybrid incompatibility; speciation; cytoplasmic-nuclear incompatibility; mitochondria; Caenorhabditis
资金
- National Institutes of Health Institutional Training Grant (Public Health Service, National Research Service Award) from National Institute of General Medical Sciences [T32GM007270]
- National Science Foundation CAREER Award [MCB-1552101]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1552101] Funding Source: National Science Foundation
How species arise is a fundamental question in biology. Species can be defined as populations of interbreeding individuals that are reproductively isolated from other such populations. Therefore, understanding how reproductive barriers evolve between populations is essential for understanding the process of speciation. Hybrid incompatibility (for example, hybrid sterility or lethality) is a common and strong reproductive barrier in nature. Here we report a lethal incompatibility between two wild isolates of the nematode Caenorhabditis nouraguensis. Hybrid inviability results from the incompatibility between a maternally inherited cytoplasmic factor from each strain and a recessive nuclear locus from the other. We have excluded the possibility that maternally inherited endosymbiotic bacteria cause the incompatibility by treating both strains with tetracycline and show that hybrid death is unaffected. Furthermore, cytoplasmic-nuclear incompatibility commonly occurs between other wild isolates, indicating that this is a significant reproductive barrier within C. nouraguensis. We hypothesize that the maternally inherited cytoplasmic factor is the mitochondrial genome and that mitochondrial dysfunction underlies hybrid death. This system has the potential to shed light on the dynamics of divergent mitochondrial-nuclear coevolution and its role in promoting speciation.
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