Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Megane Missaire, Nicolas Fraize, Jean-Christophe Comte, Bruno Truchet, Regis Parmentier, Paul-Antoine Salin, Gael Malleret
Summary: Long-term storage of information in memory relies on long-term synaptic plasticity processes. Studies have shown synaptic changes after training in long-term/reference memory and working memory tasks. Consolidation of long-term information leads to delayed synaptic potentiation, while optimal information processing into working memory triggers synaptic depression.
Article
Critical Care Medicine
Nagat El-Demerdash, Tiffany Pan, Olivia Choi, Manda Saraswati, Raymond C. Koehler, Courtney L. Robertson, Alena Savonenko
Summary: Therapies for pediatric traumatic brain injury (TBI), especially in young children, are limited and can result in long-term consequences. Animal models have provided insights into the mechanisms of pediatric TBI, but it is challenging to demonstrate clinically relevant long-term behavioral and cognitive deficits. This study used a controlled cortical impact (CCI) model of pediatric TBI to assess short- and long-term outcomes through a series of tests. The results showed functional impairments in most tests for TBI rats compared to control groups, particularly in cognitive processes related to fast one-trial learning, memory flexibility, response strategies, and recognition memory in social interactions.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Psychology, Biological
Adnan M. Massadeh, Karem H. Alzoubi, Amal M. Milhem, Abeer M. Rababa'h, Omar F. Khabour
Summary: Chronic sleep deprivation impairs both short-term and long-term memory, while chronic selenium administration can prevent this impairment by normalizing antioxidant enzyme activities in the hippocampus.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
S. Bianchi, I. Munoz-Martin, E. Covi, A. Bricalli, G. Piccolboni, A. Regev, G. Molas, J. F. Nodin, F. Andrieu, D. Ielmini
Summary: Authors propose a bio-inspired recurrent neural network based on resistive-switching synaptic arrays for autonomous exploration. The network utilizes homeostatic Hebbian learning for improved efficiency in reinforcement learning tasks. Experimental and theoretical discussions are presented to benchmark the accuracy and resilience of the proposed architecture.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Zhou-Liang Xu, GanLu Chen, XiangFei Liu, DaoFen Xie, Jie Zhang, YongGan Ying
Summary: The study found that ginsenosides can ameliorate memory impairment in rats caused by propofol anesthesia by increasing the expression levels of NGF and BDNF. Therefore, ginsenosides have the potential to serve as a novel therapeutic agent for postoperative cognitive dysfunction caused by propofol anesthesia.
Article
Behavioral Sciences
Ericks Sousa Soares, Felipe Vanz, Vagner Fagnani Linartevichi, Helena Cimarosti, Thereza Christina Monteiro de Lima
Summary: Memory is the ability to store, retrieve and use information, and it relies on a time-dependent consolidation process. The hippocampus plays a crucial role in processing all types of information, particularly spatial memory. This study investigates the involvement and recruitment of neuropeptide Y (NPY) receptors in the consolidation of spatial memory. The results demonstrate that NPY injection impairs memory consolidation, and previous stress enhances this effect. Additionally, selective antagonists for NPY receptors Y-1 and Y-2 show that both receptors are key players in spatial memory consolidation. The findings suggest that NPY modulates aversive and adaptive memory formation through receptor activation.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Nader Asadian, Houman Parsaie, Abbas Ali Vafaei, Masoumeh Dadkhah, Samira Omoumi, Katayoun Sedaghat
Summary: Disruptions in light/dark cycle can affect memory formation and retrieval in human and animals. Chronic light deprivation disrupts the neural connections for hippocampal memory formation, impacting spatial and auditory fear memory in rats.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Joel Kohler, Jie Mei, Stefanie Banneke, York Winter, Matthias Endres, Julius Valentin Emmrich
Summary: The radial arm maze is a common test to study spatial learning and memory in rodents. A newly developed refined maze showed advantages in detecting long-term cognitive impairment and quantifying exploratory behavior compared to the classic method.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Toxicology
Josje H. E. Arts, Frank Faulhammer, Steffen Schneider, Joanne G. W. Salverda
Summary: To justify the inclusion of learning and memory (L & M) tests in extended one-generation reproductive toxicity studies (EOGRTS) for chemical registration under REACH, the European Chemicals Agency referred to three publications suggesting that perturbation of thyroid hormone signaling in offspring affects spatial cognitive abilities. However, this paper challenges the validity of including these tests, questions the reliability of the publications relied upon, and argues that they cannot be used to substantiate the claim that decreased blood thyroid hormone levels alone result in impaired L & M in rats.
CRITICAL REVIEWS IN TOXICOLOGY
(2023)
Article
Neurosciences
Karem H. Alzoubi, Abdulsalam M. Halboup, Omar F. Khabour, Mahmoud A. Alomari
Summary: This study investigated the modulation of waterpipe smoking-induced memory impairment by the combined effect of vitamin E and swimming exercise. The results showed that the combination of vitamin E and swimming exercise could prevent waterpipe smoking-induced memory impairment and protect against oxidative stress in the hippocampus.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Psychology, Biological
William A. Roberts, Krista Macpherson, Sophia Robinson, Abagail Hennessy, Bram Richmond
Summary: Three experiments were conducted to investigate spatial memory in rats using a new test. Rats were tested in a dual eight-arm radial maze, where they had to remember the location of food rewards. The results showed that rats were able to form reference and working memory, and they displayed a preference for the maze with a known food reward or a cue indicating the reward location. These findings suggest that rats use a two-step strategy to navigate the maze.
LEARNING & BEHAVIOR
(2023)
Article
Behavioral Sciences
Juan M. J. Ramos, Ignacio Moron
Summary: The study found that there are different roles between the dorsal hippocampus (DHip) and ventral hippocampus (VHip) in spatial learning and memory. Specifically, DHip-lesioned rats showed an acquisition deficit, while VHip-lesioned rats only exhibited deficits under specific training protocols.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Biology
Isabel Noachtar, Ti-Anni Harris, Esmeralda Hidalgo-Lopez, Belinda Pletzer
Summary: This study investigated the sex differences in brain activation during different navigation strategies. The findings suggest that men rely more on spatial networks while women rely more on verbal networks.
COMMUNICATIONS BIOLOGY
(2022)