Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Endocrinology & Metabolism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S. Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: This study compared the reversal of arterial stiffness in surgically and medically treated PA patients and identified predictors of effective medical treatment. The findings showed that adrenalectomy and medically treated PA patients with unsuppressed plasma renin activity (PRA) had an improvement in arterial stiffness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Peripheral Vascular Disease
Ryan J. Pewowaruk, Claudia Korcarz, James H. Stein, David Bluemke, Yacob Tedla, Adam D. Gepner
Summary: This study compared the associations of several arterial stiffness calculations in a large, multiethnic cohort and found that different methods of calculating local arterial stiffness largely gave equivalent results, indicating that the variety of different arterial stiffness calculations in use do not cause inconsistent findings.
JOURNAL OF HYPERTENSION
(2023)
Review
Biochemistry & Molecular Biology
Kaido Paapstel, Jaak Kals
Summary: Arterial stiffness is an early detectable sign of vascular wall alterations and is an independent predictor of cardiovascular events and death. Metabolomics can be used to study the metabolic intermediates and products associated with arterial stiffness, providing insights for personalized cardiovascular risk assessment and treatment selection.
Article
Chemistry, Analytical
Ladislav Soukup, Pavel Jurak, Josef Halamek, Ivo Viscor, Magdalena Matejkova, Pavel Leinveber, Vlastimil Vondra
Summary: This study aims to establish a methodology using multichannel bioimpedance to evaluate pulse waves in the whole body for assessing arterial stiffness and the cardiovascular system. The results showed that aortic pulse wave velocity (PWV) is age-dependent when measured using the left carotid as the proximal location, while PWV in the upper and lower limbs is independent of age. Additionally, PWV in the left femoral artery has comparable values to carotid-femoral values published previously.
Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Endocrinology & Metabolism
Kim Phan, Ian Schiller, Nandini Dendukuri, Yessica-Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella S. Daskalopoulou
Summary: The study found that pregnant women who developed PrE showed alterations in arterial stiffness and wave reflection parameters in the early second trimester, while those who did not develop PrE did not exhibit these changes. This suggests the potential clinical utility of arterial stiffness and wave reflection parameters as an early screening tool for PrE to inform clinical management of high-risk pregnancies.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Engineering, Biomedical
Tadeusz Sondej, Iwona Jannasz, Krzysztof Sieczkowski, Andrzej Dobrowolski, Karolina Obia, Tomasz Targowski, Robert Olszewski
Summary: The study validated a new device for multi-site arterial PWV measurement using PPG sensors, with the reference device being SphygmoCor XCEL, according to ASG recommendations. Through experiments on 108 subjects, it was found that there was a high correlation between multi-site PWV and cfPWV, with the best results obtained when the proximal PPG sensor was placed on the head.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Article
Physiology
Giuseppina Novo, Daniela Di Lisi, Roberta Manganaro, Girolamo Manno, Simone Lazzara, Federico Angelo Immordino, Cristina Madaudo, Scipione Carerj, Antonio Russo, Lorena Incorvaia, Concetta Zito
Summary: In breast cancer patients, anthracycline-containing chemotherapy can lead to early changes in arterial stiffness parameters, which appear to be reversible upon cessation of anthracycline treatment and are not influenced by modifications in blood pressure values.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Environmental Sciences
Zhengce Wan, Mingyang Wu, Qing Liu, Gaojie Fan, Qing Fang, Xiya Qin, Xukuan Zhang, Yongman Lv, Youjie Wang, Jianing Bi, Lulu Song
Summary: This study investigated the independent and joint associations of metal exposure with arterial stiffness. The results showed that the concentrations of copper and chromium were associated with an increased risk of arterial stiffness. These findings provide a target for preventative strategies against cardiovascular aging.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Hematology
Hongwei Zheng, Shouling Wu, Xiaokun Liu, Guoyu Qiu, Shuohua Chen, Yuntao Wu, Junjuan Li, Chunhui Yin, Qi Zhang
Summary: Arterial stiffness is independently associated with an increased risk of new-onset heart failure, regardless of age and blood pressure. This study provides important scientific evidence by investigating a large community population.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kyung-Chae Park, Ki Soo Kim, Siyeong Yoon, Wooyeol Ahn, Simho Jeong, Junwon Choi, Soonchul Lee
Summary: This study examined the relationship between fish intake, methylmercury exposure, and arterial stiffness, finding that higher hair methylmercury levels are associated with lower arterial stiffness in seemingly healthy Korean adults.
Article
Cardiac & Cardiovascular Systems
Carolina Averta, Elettra Mancuso, Rosangela Spiga, Sofia Miceli, Elena Succurro, Teresa Vanessa Fiorentino, Maria Perticone, Gaia Chiara Mannino, Prapaporn Jungtrakoon Thamtarana, Angela Sciacqua, Giorgio Sesti, Francesco Andreozzi
Summary: This study found that individuals carrying the rs9267551 C allele in the DDAH2 gene had lower carotid-femoral pulse wave velocity (cfPWV), suggesting reduced arterial stiffness. Further analysis revealed that the variation in ADMA levels mediated the effect of the DDAH2 rs9267551 genotype on cfPWV.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Setor K. Kunutsor, Jari A. Laukkanen, Jyrki K. Virtanen
Summary: Egg or cholesterol intake is not associated with future risk of venous thromboembolism (VTE) in middle-aged and older Finnish men.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Sae Young Jae, Hyun Jeong Kim, Setor K. Kunutsor, Kanokwan Bunsawat, Sudhir Kurl, Jari A. Laukkanen, Yoon-Ho Choi
Summary: Higher cardiorespiratory fitness is independently associated with lower levels of remnant cholesterol and non-HDL-C, as well as lower odds of having elevated levels of remnant cholesterol and non-HDL-C in healthy men.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nzechukwu M. Isiozor, Setor K. Kunutsor, Dorothea Vogelsang, Ifeanyichukwu Isiozor, Jussi Kauhanen, Jari A. Laukkanen
Summary: This study aims to investigate the association between serum copper levels and the risk of cardiovascular disease (CVD) death in Finnish men. It found that elevated serum copper levels were associated with an increased risk of CVD death, and this association was consistent across different body mass index categories.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Medicine, General & Internal
Lukas Lunger, Andreas Melmer, Wolfgang Sturm, Claudia Lamina, Alexander Tschoner, Julia Engl, Armin Honlinger, Clemens Engler, Peter Willeit, Stefan Kiechl, Johann Willeit, Dietmar Ofner, Heinz Wykypiel, Markus Laimer, Herbert Tilg, Christoph Ebenbichler
Summary: The study demonstrates that weight loss induced by bariatric surgery can halt the natural progression of carotid intima media thickness (C-IMT) over a 10-year observation period, compared to a population-based control cohort.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sae Young Jae, Jari A. Laukkanen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sae Young Jae, Jari A. Laukkanen
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2023)
Article
Respiratory System
Setor K. Kunutsor, Ari Voutilainen, Jari A. Laukkanen
Summary: Increased serum Cu/Zn-ratio and Cu concentrations are linearly associated with an increased COPD risk in men.
Article
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Sudhir Kurl, Ari Voutilainen, Jari A. Laukkanen
Summary: This study aims to assess the association between C-reactive protein-to-albumin ratio (CAR) and risk of venous thromboembolism (VTE). The results showed that elevated CAR is associated with an increased risk of VTE in middle-aged and older men. Further research is needed to validate these findings and evaluate the potential value of CAR in VTE management.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Setor K. Kunutsor, Jari A. Laukkanen
Summary: This editorial discusses the 'U-shaped relationship between apolipoprotein A1 levels and mortality risk in men and women'.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jari Laukkanen, Nzechukwu M. Isiozor, Peter Willeit, Setor K. Kunutsor
Summary: The study investigated the association between haemodynamic gain index (HGI) and sudden cardiac death (SCD) risk using data from a long-term prospective cohort study. The results showed that higher HGI levels were associated with a lower risk of SCD, with a dose-response relationship and dependence on cardiorespiratory fitness (CRF) levels. Addition of HGI to a SCD risk prediction model improved risk discrimination and reclassification, but CRF remained a stronger predictor of SCD.
Article
Medicine, General & Internal
Setor K. Kunutsor, Jussi Kauhanen, Jari A. Laukkanen
Summary: This study found that frequent sauna bathing is not associated with impaired renal function or increased risk of chronic kidney disease (CKD).
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Nzechukwu M. Isiozor, Setor K. Kunutsor, Ari Voutilainen, Jari A. Laukkanen
Summary: This study found that improving healthy behaviors and LE8 scores can lower the risk of future heart disease mortality. Men with a total LE8 score of more than 550 had a lower risk of heart disease and overall mortality compared to those with a score of <=420. Increasing the LE8 score by 50 can lower the risk of heart disease and overall mortality.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jari A. Laukkanen, Sae Young Jae, Sudhir Kurl, Setor K. Kunutsor
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Obstetrics & Gynecology
Lena Tschiderer, Lisa Seekircher, Peter Willeit, Sanne A. E. Peters
Summary: Cardiovascular disease is the leading cause of death in women worldwide, but there are uncertainties in prediction, diagnosis, and treatment. Risk scores are used for prediction, and pregnancy- and reproductive-factors may affect cardiovascular disease risk. However, adding female-specific factors to existing models does not significantly improve cardiovascular risk prediction. Further research is needed to determine if pregnancy-related factors improve risk prediction in young women for better prevention and treatment of cardiovascular disease.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2023)