Article
Cardiac & Cardiovascular Systems
Qin Duan, Hongmei Tao, Qian Dong, Kangla Liao, Yunjing Yang, Xiaocheng Cheng, Ping Ge
Summary: The non-invasive myocardial work index (MWI) is found to be more associated with hypertension-mediated organ damage (HMOD) and diastolic dysfunction in hypertensive patients compared to the classical method of arterial elastance/left ventricular (LV) elastance index (Ea/Ees).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Juraj Jug, Didi Delalic, Valerija Bralic Lang, Tomislav Bulum, Ingrid Prkacin
Summary: This study aimed to compare the pulse wave velocity (PWV) values in subjects with prediabetes, non-dipper profile, and arterial hypertension with their values in healthy subjects. The results showed that subjects with prediabetes and non-dipping profiles had significantly higher PWV values. Age, blood pressure, nocturnal indices, and fasting plasma glucose were identified as independent predictors of PWV values. These findings highlight the importance of prediabetes and non-dipping hypertension as factors contributing to increased PWV.
Article
Cardiac & Cardiovascular Systems
Pierre-Yves Courand, Jerome Lenoir, Adrien Grandjean, Damien Garcia, Brahim Harbaoui, Pierre Lantelme
Summary: The study found that SCORE underestimates the 10-year cardiovascular mortality risk in both historical and contemporary cohorts of hypertensive patients. An update to the algorithm predicting cardiovascular mortality in hypertensive patients is needed.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaolin Liao, Yuanshan Han, Ying He, Jianjun Liu, Yuhong Wang
Summary: Hypertension commonly leads to target organ damage in the heart, brain, kidney, and blood vessels, including atherosclerosis, plaque formation, cardiovascular and cerebrovascular events, and renal failure. Mitochondrial dysfunction has been identified as a crucial factor in hypertensive target organ damage, leading to increasing interest in mitochondria-targeted therapies. Natural compounds have shown potential in ameliorating mitochondrial dysfunction in hypertensive target organ damage. This review summarizes the contribution of mitochondrial dysfunction to the development of target organ damage in hypertension and discusses therapeutic strategies based on natural compounds that target mitochondrial dysfunction, which may be beneficial for preventing and treating hypertensive target organ damage.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Nicola Di Daniele, Giulia Marrone, Manuela Di Lauro, Francesca Di Daniele, Daniela Palazzetti, Cristina Guerriero, Annalisa Noce
Summary: The most common manifestation of cardiovascular diseases is arterial hypertension, which can be managed through proper diet like CRD to reduce blood pressure and improve endothelial function.
Article
Cardiac & Cardiovascular Systems
Eva Gerdts, Isabella Sudano, Sofie Brouwers, Claudio Borghi, Rosa Maria Bruno, Claudio Ceconi, Veronique Cornelissen, Francois Dievart, Marc Ferrini, Thomas Kahan, Maja Lisa Lochen, Angela H. E. M. Maas, Felix Mahfoud, Anastasia S. Mihailidou, Trine Moholdt, Gianfranco Parati, Giovanni de Simone
Summary: Sex chromosomes and sex hormones play differential roles in blood pressure regulation and cardiovascular risk factors between females and males with essential arterial hypertension. The risk for cardiovascular disease is higher in females at lower blood pressure levels, suggesting the need for sex-specific thresholds in hypertension diagnosis. It is currently unknown if hypertension should be managed differently in females and males, highlighting the need for focused research on sex-specific prevention and management.
EUROPEAN HEART JOURNAL
(2022)
Review
Chemistry, Medicinal
Xiaolin Liao, Yuanshan Han, Chuanpu Shen, Jianjun Liu, Yuhong Wang
Summary: This review provides an overview of the role of NLRP3 inflammasome in hypertensive target organ damage (TOD) and the natural products and formulations that inhibit it. The activation of NLRP3 inflammasome exacerbates tissue damage and dysfunction in hypertensive TOD, and natural products such as curcumin, resveratrol, triptolide, and allicin have been shown to have protective effects.
PHYTOTHERAPY RESEARCH
(2023)
Review
Cell Biology
Ulrich O. Wenzel, Heimo Ehmke, Marlies Bode
Summary: This article highlights the role of inflammation in hypertension and hypertensive end-organ damage, noting that immune cells from both the innate and adaptive immune systems are involved. It also discusses the impact of sodium intake on immune cell function and the potential benefits of modulating the immune response to reduce the severity of hypertension and end-organ damage.
CELL AND TISSUE RESEARCH
(2021)
Article
Cell Biology
Yu Hao, Xue Li, Ye Zhu, Jianting Ke, Tanqi Lou, Man Li, Cheng Wang
Summary: This study investigated the associations between age-dependent variations in isolated systolic/diastolic hypertension (ISH/IDH) and target organ damage in chronic kidney disease (CKD). It found that ISH was associated with a higher risk of target organ damage regardless of age, while IDH was only correlated with renal injury in younger CKD patients.
Article
Medicine, General & Internal
Rosario Alonso-Dominguez, Natalia Sanchez-Aguadero, Maria C. Patino-Alonso, Cristina Agudo-Conde, Angela de Cabo-Laso, Marta Gomez-Sanchez, Leticia Gomez-Sanchez, Emiliano Rodriguez-Sanchez, Luis Garcia-Ortiz, Manuel A. Gomez-Marcosa
Summary: The study found a strong correlation between different measurements of arterial stiffness, with carotid-femoral and brachial-ankle pulse wave velocity positively associated with vascular target organ damage, and the latter also positively associated with left ventricular hypertrophy. However, these associations disappeared when adjusting for cardiovascular risk factors.
ANNALS OF MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Carlos J. Pirola, Silvia Sookoian
Summary: This study found that non-alcoholic fatty liver disease (NAFLD) mediates the relationship between obesity and arterial hypertension.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Marialuisa Perrotta, Daniela Carnevale
Summary: Hypertension is a multifactorial disease with pathophysiological mechanisms involving not only classical factors but also the immune system. Studies have shown the important role of neuroimmune interactions in hypertension, with specific brain areas modulating immune responses playing a crucial role in the development of high blood pressure.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Cardiac & Cardiovascular Systems
Tong Zhu, Qingxun Hu, Yanggang Yuan, Huijuan Yao, Jian Zhang, Jia Qi
Summary: Vascular remodeling is the pathological basis for many cardiovascular diseases, and mitochondrial dynamics play a crucial role in this process. The balance of mitochondrial fusion and fission is more important than individual processes, and it can result in target-organ damage by interfering with the blood supply to major organs. The protective effect of mitochondrial dynamics modulators on target-organs has been demonstrated in various studies, but their use in the treatment of cardiovascular diseases needs further verification through clinical studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Xiao Lin, Muhammad Hasnain Ehsan Ullah, Xiong Wu, Feng Xu, Su-Kang Shan, Li-Min Lei, Ling-Qing Yuan, Jun Liu
Summary: This review summarizes the cerebro-cardiovascular risk in primary aldosteronism (PA) and emphasizes the harmful effects of excess aldosterone on target organs. Both surgical and medical treatments show long-term benefits in improving cerebro-cardiovascular outcomes and reducing mortality. Understanding these risks is essential for early diagnosis and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Federica Ilardi, Adriana Postolache, Raluca Dulgheru, Mai-Linh Nguyen Trung, Nils de Marneffe, Tadafumi Sugimoto, Yun Yun Go, Cecile Oury, Giovanni Esposito, Patrizio Lancellotti
Summary: This study evaluated the relationship between non-invasive myocardial work indices and stages of cardiac damage in aortic stenosis. The results showed that as the severity of cardiac damage increased, the values of global work index and global constructive work decreased. Furthermore, the global work index and global constructive work were significantly associated with mortality and could accurately predict death in patients with aortic stenosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Peripheral Vascular Disease
Nicolas Renna, Daniel Piskorz, Diego Stisman, Diego Martinez, Ludmila Lescano, Sergio Vissani, Walter Espeche, Diego Marquez, Roberto Parodi, Diego Naninni, Marcos Baroni, Daniel Llanos, Rocio Martinez, Jessica Barochinner, Gustavo Staffieri, Fernando Lanas, Monica Velasquez, Marcos Marin, Bryan Williams, Irene Ennis
Summary: This document provides a comprehensive review of the scientific evidence on the use of single pill combinations (SPCs) in the treatment of hypertension. It highlights the importance of using multiple drugs to achieve blood pressure goals and the inverse relationship between treatment adherence and the number of drugs taken. The document also discusses the effectiveness and adverse effects of SPCs, their use in special populations, and their impact on hypertensive-mediated organ damage.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Marco Merlo, Giulia Gagno, Anna Baritussio, Barbara Bauce, Elena Biagini, Marco Canepa, Alberto Cipriani, Silvia Castelletti, Santo Dellegrottaglie, Andrea Igoren Guaricci, Massimo Imazio, Giuseppe Limongelli, Maria Beatrice Musumeci, Vanda Parisi, Silvia Pica, Gianluca Pontone, Giancarlo Todiere, Camilla Torlasco, Cristina Basso, Gianfranco Sinagra, Pasquale Perrone Filardi, Ciro Indolfi, Camillo Autore, Andrea Barison
Summary: Cardiac magnetic resonance (CMR) is an essential tool for evaluating cardiomyopathy patients, providing precise cardiac data and non-invasive assessment of myocardial tissue for early diagnosis, individualized treatment, and prognostic risk assessment. New experimental CMR techniques are being developed to further expand our knowledge in the field of cardiomyopathies.
HEART FAILURE REVIEWS
(2023)
Article
Peripheral Vascular Disease
Norm R. C. Campbell, Paul K. Whelton, Marcelo Orias, Richard D. Wainford, Francesco P. Cappuccio, Nicole Ide, Bruce Neal, Jennifer Cohn, Laura K. Cobb, Jacqui Webster, Kathy Trieu, Feng J. He, Rachael M. McLean, Adriana Blanco-Metzler, Mark Woodward, Nadia Khan, Yoshihiro Kokubo, Leo Nederveen, JoAnne Arcand, Graham A. MacGregor, Mayowa O. Owolabi, Liu Lisheng, Gianfranco Parati, Daniel T. Lackland, Fadi J. Charchar, Bryan Williams, Maciej Tomaszewski, Cesar A. Romero, Beatriz Champagne, Mary R. L'Abbe, Michael A. Weber, Markus P. Schlaich, Agnes Fogo, Valery L. Feigin, Rufus Akinyemi, Felipe Inserra, Bindu Menon, Marcia Simas, Mario Fritsch Neves, Krassimira Hristova, Carolyn Pullen, Sanjay Pandeya, Junbo Ge, Jorge E. Jalil, Ji-Guang Wang, Jiri Wideimsky, Reinhold Kreutz, Ulrich Wenzel, Michael Stowasser, Manuel Arango, Athanasios Protogerou, Eugenia Gkaliagkousi, Flavio Danni Fuchs, Mansi Patil, Andy Wai-Kwong Chan, Janos Nemcsik, Ross T. Tsuyuki, Sanjeevi Nathamuni Narasingan, Nizal Sarrafzadegan, Maria Eugenia Ramos, Natalie Yeo, Hiromi Rakugi, Agustin J. Ramirez, Guillermo Alvarez, Adel Berbari, Cho-il Kim, Sang-Hyun Ihm, Yook-Chin Chia, Tsolmon Unurjargal, Hye Kyung Park, Kolawole Wahab, Helen McGuire, Naranjargal J. Dashdorj, Mohammed Ishaq, Deborah Ignacia D. Ona, Leilani B. Mercado-Asis, Aleksander Prejbisz, Marianne Leenaerts, Carla Simao, Fernando Pinto, Bader Ali Almustafa, Jonas Spaak, Stefan Farsky, Dragan Lovic, Xin-Hua Zhang
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Dean S. Picone, Elif Stoneman, Antoine Cremer, Martin G. Schultz, Petr Otahal, Alun D. Hughes, J. Andrew Black, Willem Jan Bos, Chen-Huan Chen, Hao-Min Cheng, Nathan Dwyer, Peter Lacy, Esben Laugesen, Fuyou Liang, Hack-Lyoung Kim, Nobuyuki Ohte, Sho Okada, Stefano Omboni, Christian Ott, Telmo Pereira, Giacomo Pucci, Ronak Rajani, Roland Schmieder, Manish D. Sinha, Ralph Stewart, George A. Stouffer, Kenji Takazawa, Jiguang Wang, Thomas Weber, Berend E. Westerhof, Bryan Williams, Hirotsugu Yamada, James E. Sharman
Summary: Accurate blood pressure measurement is crucial for cardiovascular risk management. A study found that for the same cuff systolic blood pressure, women had higher invasive aortic systolic blood pressure than men. Cuff measurements may underestimate cardiovascular risk in women.
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Paola Gargiulo, Wanda Acampa, Gaetano Asile, Vincenza Abbate, Ermanno Nardi, Federica Marzano, Roberta Assante, Carmela Nappi, Antonio Luca Maria Parlati, Christian Basile, Santo Dellegrottaglie, Stefania Paolillo, Alberto Cuocolo, Pasquale Perrone-Filardi
Summary: Heart failure is a major global cause of morbidity and mortality, with significant impact on quality of life and healthcare costs. Assessment of myocardial sympathetic innervation function plays a crucial role in prognosis assessment of heart failure patients. This review summarizes the latest clinical applications of iodine-123 metaiodobenzylguanidine (I-123-MIBG) imaging in heart failure patients and related comorbidities.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto M. Marra, Roberta D'Assante, Andrea Salzano, Massimo Iacoviello, Vincenzo Triggiani, Giuseppe Rengo, Giuseppe Limongelli, Daniele Masarone, Maria Perticone, Antonio Cimellaro, Pasquale Perrone Filardi, Stefania Paolillo, Paola Gargiulo, Antonio Mancini, Maurizio Volterrani, Olga Vriz, Roberto Castello, Andrea Passantino, Michela Campo, Pietro A. Modesti, Alfredo De Giorgi, Michele Arcopinto, Anna D'Agostino, Valeria Raparelli, Andrea M. Isidori, Valeria Valente, Federica Giardino, Giulia Crisci, Angela Sciacqua, Marcella Savoia, Toru Suzuki, Eduardo Bossone, Antonio Cittadini
Summary: This study investigated the prognostic impact of testosterone deficiency (TD) on women with heart failure with reduced ejection fraction (HFrEF). It found that around one-third of women with HFrEF had TD, which significantly affected their morbidity and mortality. TD was associated with a worse clinical profile including exercise capacity, right ventricular-pulmonary arterial coupling, and renal function.
Review
Cardiac & Cardiovascular Systems
Paola Gargiulo, Federica Marzano, Marco Salvatore, Christian Basile, Davide Buonocore, Antonio Luca Maria Parlati, Ermanno Nardi, Gaetano Asile, Vincenza Abbate, Angela Colella, Alfonsina Chirico, Caterina Marciano, Stefania Paolillo, Pasquale Perrone-Filardi
Summary: Heart failure is a significant health issue with a high burden on both society and the economy. Recent research has shown that microRNAs play an important role in the development and prognosis of heart failure, serving as biomarkers for diagnosis and prognosis. Exploration of microRNAs as potential therapeutic targets is also ongoing.
Article
Cardiac & Cardiovascular Systems
Nicola Riccardo Pugliese, Nicolo De Biase, Lavinia Del Punta, Alessio Balletti, Silvia Armenia, Simona Buralli, Alessandro Mengozzi, Stefano Taddei, Marco Metra, Matteo Pagnesi, Barry A. Borlaug, Bryan Williams, Stefano Masi
Summary: This study evaluated the role of hypertensive response to exercise (HRE) in heart failure and investigated the hemodynamic and prognostic factors associated with HRE. The results showed that systolic blood pressure and workload slope were significantly different in heart failure patients, and HRE was associated with adverse outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Peripheral Vascular Disease
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Boehm
Summary: This study investigated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure reductions and cardiovascular outcomes following radiofrequency renal denervation (RDN) in hypertensive patients. The results showed that radiofrequency RDN reduced blood pressure safely through 36 months, regardless of the number and type of baseline antihypertensive medication classes.
Article
Peripheral Vascular Disease
Peter S. Lacy, Dawid Jedrzejewski, Ewan McFarlane, Bryan Williams
Summary: This study compared the effectiveness of different blood pressure measurement modalities in predicting hypertension-mediated cardiac damage. The results showed that under strict measurement conditions, clinic blood pressure and noninvasive central aortic systolic pressure were as effective as 24-hour ambulatory blood pressure monitoring in predicting left ventricular mass index. Previous observations of inferiority of clinic blood pressure in predicting cardiac damage may be due to poor measurement technique or failure to exclude white-coat hypertension.
JOURNAL OF HYPERTENSION
(2023)
Letter
Peripheral Vascular Disease
George Stergiou, Thomas MacDonald, Robin Young, Konstantinos G. Kyriakoulis, Anastasios Kollias, Bryan Williams, Maciej Tomaszewski
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Dawid Jedrzejewski, Ewan McFarlane, Peter Lacy, Bryan Williams
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Thomas MacLennal MacDonald, Isla Shelah Mackenzie, Amy Rogers, Neil R. Poulter, Bryan Williams, Morris J. Brown, David J. Webb, Ian Ford, David Rorie, Kerr Grieve, Fillippo Pigazzani, Peter M. Rothwell, Robin Young, Alex McConnachie, Chim C. Lang
JOURNAL OF HYPERTENSION
(2023)
Meeting Abstract
Peripheral Vascular Disease
Nicola Riccardo Pugliese, Francesco Faita, Frank Ruschitzka, Stefano Taddei, Bryan Williams, Francesco Antonini Canterin, Stefano Masi
JOURNAL OF HYPERTENSION
(2023)