Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Caroline A. Berge, Ingeborg Eskerud, Elise B. Almeland, Terje H. Larsen, Eva R. Pedersen, Svein Rotevatn, Mai Tone Lonnebakken
Summary: This study aimed to investigate the association between hypertension and extensive non-obstructive coronary artery disease (CAD) in patients with symptomatic chronic coronary syndrome (CCS). The results showed that hypertension was associated with extensive non-obstructive CAD in CCS patients, independent of factors such as sex, age, smoking, diabetes, statin treatment, obesity, and calcium score.
Review
Cardiac & Cardiovascular Systems
Natasha Corballis, Vasiliki Tsampasian, Ioannis Merinopoulis, Tharusha Gunawardena, U. Bhalraam, Simon Eccleshall, Marc R. Dweck, Vassilios Vassiliou
Summary: Computed tomography coronary angiography (CTCA) is a safe strategy for investigating patients with stable angina, showing no increased risk of major adverse cardiovascular events (MACE) compared to invasive coronary angiography (ICA), and a reduction in the need for revascularization.
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Sophie E. van Rosendael, Pieter van der Bijl, Alexander R. van Rosendael, Pieter H. Kitslaar, Johan H. C. Reiber, J. Wouter Jukema, Martin B. Leon, Nina Ajmone Marsan, Juhani Knuuti, Jeroen J. Bax
Summary: This study compared the pericoronary adipose tissue (PCAT) attenuation between acute coronary syndrome and stable coronary artery disease patients. The results showed that the PCAT attenuation in culprit lesion precursors of acute coronary syndrome patients was significantly higher than nonculprit lesions and lesions of stable coronary artery disease patients. Therefore, PCAT attenuation may be a novel marker for identifying high-risk plaques.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Borek Foldyna, Thomas Mayrhofer, Michael T. Lu, Julia Karady, Marton Kolossvary, Maros Ferencik, Svati H. Shah, Neha J. Pagidipati, Pamela S. Douglas, Udo Hoffmann
Summary: The prognostic value of CT-derived coronary artery disease (CAD) characteristics differs across categories of clinical cardiovascular risk. Among patients with low cardiovascular disease risk, CAD >= 50% has the highest prognostic value, while coronary artery calcium (CAC) and high-risk plaque (HRP) have higher prognostic value among patients with high cardiovascular disease risk.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leonie M. Becker, Joyce Peper, Bram J. L. A. Verhappen, Laurens A. Swart, Admir Dedic, Willem G. van Dockum, Martin van der Ent, Kees-Jan Royaards, Andre Niezen, Jan-Hein J. Hensen, Jan-Peter van Kuijk, Firdaus A. A. Mohamed Hoesein, Tim Leiner, Tobias A. Bruning, Martin J. Swaans
Summary: This study assessed the impact of CT-derived fractional flow reserve (FFR-CT) on clinical decision-making and patient prognosis in patients with stable coronary artery disease (CAD). The results showed that the addition of FFR-CT resulted in a reduction in invasive diagnostic testing and fewer occurrences of revascularizations.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jing-Lu Jin, Hui-Wen Zhang, Ye-Xuan Cao, Hui-Hui Liu, Qi Hua, Yan-Fang Li, Yan Zhang, Yuan-Lin Guo, Na-Qiong Wu, Cheng-Gang Zhu, Rui-Xia Xu, Ying Gao, Chuan-Jue Cui, Geng Liu, Jing Sun, Qian Dong, Jian-Jun Li
Summary: This study found that NAFLD-FS and FIB-4 scores are related to the severity of coronary artery disease, coronary calcification, and cardiovascular events.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lixue Xu, Fang Li, Kewei Wu, Zhaohui Zhong, Rongchong Huang, Yinghao Xu, Zhenchang Wang, Zhenghan Yang, Yi He
Summary: This study investigated the diagnostic accuracy, confidence, and interobserver agreement of subtraction coronary CT angiography (CCTA) compared to invasive coronary angiography on 320-row CT. Results showed that CCTA with subtraction information achieved better diagnostic accuracy and interobserver agreement in cases with severe calcification, but the effect was unclear in cases with non-severe calcification.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Alexandra N. Nowbar, Christopher Rajkumar, Rasha K. Al-Lamee, Darrel P. Francis
Summary: Recent randomised controlled trials have overturned traditional beliefs about necessary hospital procedures for stable coronary artery disease patients, leading to discussions about the implications for physicians and patients.
Review
Medicine, General & Internal
Andrea Zito, Mattia Galli, Giuseppe Biondi-Zoccai, Antonio Abbate, Pamela S. Douglas, Giuseppe Princi, Domenico D'Amario, Cristina Aurigemma, Enrico Romagnoli, Carlo Trani, Francesco Burzotta
Summary: Comparing different diagnostic strategies for initial assessment of suspected stable CAD, CCTA shows similar health effects to direct ICA referral and better health outcomes compared to exercise ECG and SPECT-MPI. However, it is associated with more index revascularization compared to exercise ECG.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kristina Fladseth, Haakon Lindekleiv, Christopher Nielsen, Andrea Ohrn, Andreas Kristensen, Jan Mannsverk, Maja-Lisa Lochen, Inger Njolstad, Tom Wilsgaard, Ellisiv B. Mathiesen, Audun Stubhaug, Thor Trovik, Svein Rotevatn, Signe Forsdahl, Henrik Schirmer
Summary: The study found that low pain tolerance is associated with an increased risk of coronary angiography and death, especially in women. There was no significant association between pain tolerance and nonobstructive CAD or clinical presentation to coronary angiography.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian P. Houbois, Gauri Karur, Jennifer Fratesi, Micheal C. McInnis
Summary: The prevalence of LCA in the study was 11%, with a majority being unilateral and having an average vessel length of 2 intercostal spaces. Gender had no significant impact on vessel distribution, and there was substantial agreement among observers in detecting LCA.
EUROPEAN RADIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Mohamed Farag, Marta Peverelli, Nikolaos Spinthakis, Ying X. Gue, Mohaned Egred, Diana A. Gorog
Summary: This review discusses the therapeutic management dilemma presented by patients with transient ST-elevation myocardial infarction (STEMI) or spontaneous resolution (SpR) of ST-segment elevation. The potential mechanisms underlying SpR, its relation to clinical outcomes, and the management options for transient STEMI patients with a focus on immediate versus early percutaneous coronary intervention are explored. Available data suggest that deferring angiography and revascularization within 24-48 hours in these patients is reasonable and may lead to similar or better outcomes compared to immediate angiography. Further randomized trials are needed to determine the optimal pharmacological and invasive strategies for this patient population.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Christophe Vandenbriele, Deepa J. Arachchillage, Pascal Frederiks, Gennaro Giustino, Diana A. Gorog, Mario Gramegna, Stefan Janssens, Bart Meyns, Amin Polzin, Mara Scandroglio, Benedikt Schrage, Gregg W. Stone, Guido Tavazzi, Thomas Vanassche, Pascal Vranckx, Dirk Westermann, Susanna Price, Alaide Chieffo
Summary: There is growing interest in the use of mechanical circulatory support for patients with cardiogenic shock, but the delicate balance between bleeding and thrombosis poses challenges for patient outcomes. This article presents an anti-Factor Xa/activated partial thromboplastin time-guided anticoagulation algorithm and discusses the monitoring pitfalls of heparin in critically ill patients, aiming to guide physicians in standardizing anticoagulation treatment to reduce device-related morbidity and mortality.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Jonathan P. Piccini, Valeria Caso, Stuart J. Connolly, Keith A. A. Fox, Jonas Oldgren, W. Schuyler Jones, Diana A. Gorog, Vaclav Durdil, Thomas Viethen, Christoph Neumann, Hardi Mundl, Manesh R. Patel
Summary: This study compared the incidence of bleeding in patients with atrial fibrillation between Asundexian and apixaban, showing that Asundexian resulted in lower rates of bleeding compared with standard dosing of apixaban.
Review
Hematology
Diana A. Gorog, Ying X. Gue, Tze-Fan Chao, Laurent Fauchier, Jose Luis Ferreiro, Kurt Huber, Stavros V. Konstantinidis, Deirdre A. Lane, Francisco Marin, Jonas Oldgren, Tatjana Potpara, Vanessa Roldan, Andrea Rubboli, Dirk Sibbing, Hung-Fat Tse, Gemma Vilahur, Gregory Y. H. Lip
Summary: This article summarizes the consensus on bleeding risk assessments in patients with atrial fibrillation (AF) and venous thromboembolism (VTE), including bleeding risk factors, definitions, and the consideration of patient values and preferences in balancing bleeding against thromboembolism risks.
THROMBOSIS AND HAEMOSTASIS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Ying X. Gue, Diana A. Gorog, Gregory Y. H. Lip
Editorial Material
Cardiac & Cardiovascular Systems
Ying X. Gue, Diana A. Gorog, Gregory Y. H. Lip
Article
Cardiac & Cardiovascular Systems
Rahim Kanji, Ying X. Gue, Vassilios Memtsas, Neil H. Spencer, Diana A. Gorog
Summary: Spontaneous reperfusion in ST-segment elevation myocardial infarction (STEMI) patients is related to decreased thrombotic profile and improved outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Hematology
Diana A. Gorog, Visvesh Jeyalan, Rafaella I. L. Markides, Eliano P. Navarese, Young-Hoon Jeong, Mohamed Farag
Summary: There are differences in bleeding risk between East Asians and non-East Asians in acute coronary syndrome patients undergoing dual antiplatelet therapy (DAPT). In East Asians, reducing the intensity or duration of DAPT can minimize bleeding risk. In non-East Asians, reducing the intensity of DAPT may increase the risk of ischemia. Reducing the duration of DAPT can reduce bleeding risk without significant impact on ischemic risk.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Tarun K. Mittal, Sandeep S. Hothi, Vinod Venugopal, John Taleyratne, David O'Brien, Kazi Adnan, Joban Sehmi, Georgios Daskalopoulos, Aparna Deshpande, Sara Elfawal, Vinoda Sharma, Rajai A. Shahin, Mengshi Yuan, Dominik Schlosshan, Andrew Walker, Saif-El-Dean Abdel Rahman, Imran Sunderji, Sidhesh Wagh, Jocelyn Chow, Mohammed Masood, Sumeet Sharma, Sharad Agrawal, Chary Duraikannu, Elisa Mcalindon, Saeed Mirsadraee, Edward D. Nicol, Andrew D. Kelion
Summary: In this study, the use of FFR-CT in clinical practice was audited against England's guidance, and its diagnostic accuracy and cost were assessed. The study found that FFR-CT had a low positive predictive value, making it potentially more expensive than conventional stress imaging strategies.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Critical Care Medicine
Charlotte J. Van Edom, Diana A. Gorog, Christophe Vandenbriele
INTENSIVE CARE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Diana A. Gorog, Jose Luis Ferreiro, Ingo Ahrens, Junya Ako, Tobias Geisler, Sigrun Halvorsen, Kurt Huber, Young-Hoon Jeong, Eliano P. Navarese, Andrea Rubboli, Dirk Sibbing, Jolanta M. Siller-Matula, Robert F. Storey, Jack W. C. Tan, Jurrien M. ten Berg, Marco Valgimigli, Christophe Vandenbriele, Gregory Y. H. Lip
Summary: Dual antiplatelet therapy (DAPT) reduces the risk of ischaemic events but increases bleeding risk in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Strategies to reduce bleeding include de-escalation of DAPT intensity or abbreviation of DAPT duration, which both require individual assessment of ischaemic and bleeding risks.
NATURE REVIEWS CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Tarun K. Mittal, Sandeep S. Hothi, Edward D. Nicol, Andrew D. Kelion
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Hematology
Rahim Kanji, Joshua Leader, Vassilios Memtsas, Diana A. Gorog
Summary: Thrombus formation in severely stenosed arteries is mainly initiated by high shear activation of platelets, and soluble platelet agonists have a secondary role in thrombus growth and stability. Conventional platelet function tests only evaluate the soluble agonist-dependent pathway of aggregation. The Global Thrombosis Test (GTT) simulates thrombus formation in whole blood under high shear flow and measures occlusive thrombus formation time and spontaneous thrombolysis. The GTT-3 model provides additional assessment of thrombus stability and can be used to evaluate the impact of antithrombotic medications on thrombus stability at high shear.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2023)
Article
Medicine, General & Internal
Peter W. Horby, Jonathan R. Emberson, Marion Mafham, Mark Campbell, Leon Peto, Guilhenne Pessoa-Amorim, Enti Spata, Natalie Staplin, Catherine Lowe, David R. Chadwick, Christopher Brightling, Richard Stewart, Paul Collini, Abdul Ashish, Christopher A. Green, Ben Prudon, Timothy Felton, Anthony Kerry, J. Kenneth Baillie, Maya H. Such, Jeremy Day, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Marian Knight, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, Guy Thwaites, Richard Haynes, Martin J. Landray
Summary: This study evaluated the use of baricitinib in the treatment of patients hospitalized with COVID-19. The results showed that baricitinib significantly reduced the risk of death, although the effect size was slightly smaller than previous trials. Overall evidence suggests that JAK inhibitors can reduce mortality in hospitalized COVID-19 patients by about 20%.
Article
Medicine, General & Internal
Peter W. Horby, Marion Mafham, Leon Peto, Mark Campbell, Guilherme Pessoa-Amorim, Enti Spata, Natalie Staplin, Jonathan R. Emberson, Benjamin Prudon, Paul Hine, Thomas Brown, Christopher A. Green, Rahuldeb Sarkar, Purav Desai, Bryan Yates, Tom Bewick, Simon Tiberi, Tim Felton, J. Kenneth Baillie, Maya H. Bitch, Lucy C. Chappell, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathryn Rowan, David M. Weinreich, Richard Haynes, Martin J. Landray
Summary: This study evaluated the efficacy and safety of the combination therapy of casirivimab and imdevimab in patients hospitalized with COVID-19. The results showed that this combination therapy reduced the 28-day mortality rate in patients without detectable antibodies to SARS-CoV-2 infection at baseline, but not in those with detectable antibodies.