Article
Multidisciplinary Sciences
Wen Jia, Xiaodong Wang, Guangxiang Chen, Huilin Cao, Guang Yue, Mei Luo, Lijuan Luo, Dong Liu, Xiaoping Lei, Wenbin Dong, Xueling Ma, Yuan Shi
Summary: This study investigated the changes in functional network connectivity (FNC) in very preterm infants treated with late systemic dexamethasone using resting-state functional magnetic resonance imaging (rs-fMRI). The results showed that this treatment can improve FNC and is positively correlated with neurodevelopmental outcomes.
Article
Neurosciences
Lauren Wagner, Megan Banchik, Nana J. Okada, Nicole McDonald, Shafali S. Jeste, Susan Y. Bookheimer, Shulamite A. Green, Mirella Dapretto
Summary: Despite growing evidence, it remains unclear how alterations in thalamic functional connectivity emerge early in human development in autism spectrum disorder (ASD). In this study, researchers investigated the thalamocortical functional connectivity in infants at high and typical familial likelihood for ASD. The findings suggest that ASD may be characterized by early differences in thalamic gating, which could underlie atypical sensory processing and attention to social vs. nonsocial stimuli observed in ASD.
Review
Pediatrics
Benjamin W. Ackermann, Daniel Klotz, Roland Hentschel, Ulrich H. Thome, Anton H. van Kaam
Summary: High-frequency ventilation (HFV) is a respiratory support mode that has been used for over 30 years in neonates. It can effectively restore lung function and potentially limit ventilator-induced lung injury. Understanding how HFV works and its clinical application is crucial for its optimal and safe use. This article presents important aspects of HFV, including gas exchange, lung-protective concepts, clinical use, and possible adverse effects. It also discusses the use of HFV in respiratory distress syndrome in preterm infants and respiratory failure in term neonates.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Janelle Liu, Karen Grewen, Wei Gao
Summary: Altered functional connectivity in infants with prenatal exposure to opioids can influence fetal programming and neurotransmitter signaling. Medication for opioid use disorder (MOUD) during pregnancy has been associated with better birth and long-term developmental outcomes, but the underlying neural mechanisms are unknown. This study aimed to investigate the effects of prenatal opioid/other drug exposure (PODE) and the neural basis of MOUD benefits by examining newborn brain functional organization. The findings confirm altered brain organization in PODE infants and highlight the potential brain basis of the beneficial effects of MOUD on development.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Cooper J. Mellema, Albert A. Montillo
Summary: This study aims to propose new measures of human brain connectivity to address gaps in the existing measures and facilitate the study of brain function, cognitive capacity, and early markers of human disease. Two new measures of functional and effective connectivity are proposed, using machine learning techniques to capture linear and nonlinear aspects of brain associations. The proposed measures demonstrate higher reproducibility and predictive power compared to traditional measures.
JOURNAL OF NEURAL ENGINEERING
(2023)
Review
Neurosciences
Laurentius Huber (Renzo), Emily S. Finn, Yuhui Chai, Rainer Goebel, Ruediger Stirnberg, Tony Stoecker, Sean Marrett, Kamil Uludag, Seong-Gi Kim, SoHyun Han, Peter A. Bandettini, Benedikt A. Poser
Summary: Recent advances in fMRI technology have enabled researchers to study information processing in the cortical layers more effectively, particularly in terms of connectivity. However, layer-fMRI still faces challenges that require more flexible and precise methods to address. This article describes newly developed acquisition methodologies that can provide more comprehensive data for investigating brain network connections.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Behavioral Sciences
Hilary Toulmin, Jonathan O'Muircheartaigh, Serena J. Counsell, Shona Falconer, Andrew Chew, Christian F. Beckmann, A. David Edwards
Summary: Preterm infants are at high risk of long-term motor and neurocognitive deficits. Structural MRI at birth does not accurately predict outcomes, suggesting the importance of thalamocortical connections in neurocognitive development during the perinatal period.
Article
Multidisciplinary Sciences
Jerome Baranger, Charlie Demene, Alice Frerot, Flora Faure, Catherine Delanoe, Hicham Serroune, Alexandre Houdouin, Jerome Mairesse, Valerie Biran, Olivier Baud, Mickael Tanter
Summary: This study utilizes functional ultrasound for bedside deep brain resting-state functional connectivity imaging in neonates, revealing interhemispheric connectivity in preterm newborns and fine-grain correlations within brain tissue. Furthermore, decreased occurrence of thalamo-cortical networks is observed in very preterm neonates compared to control term newborns, suggesting potential applications for early brain function monitoring.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Kylie Isenburg, Thomas M. Morin, Maya L. Rosen, David C. Somers, Chantal E. Stern
Summary: Studies have found that certain brain regions are activated during attentional deployment via long-term memories. We conducted an analysis of task-based functional connectivity to study the communication between these brain regions underlying long-term memory guided attention. Our results showed that different subnetworks, such as default mode, cognitive control, and dorsal attention, contribute differently to long-term memory guided attention, and the connectivity at the network level shifts based on attentional demands. We also found specific nodes within these subnetworks that play a crucial role in facilitating long-term memory guided attention.
Article
Neurosciences
M. Fiona Molloy, Zeynep M. Saygin
Summary: This study used neonatal data to uncover the intrinsic functional brain networks and individual differences. The study found the most individual variability in different networks among neonates, and this variability was not influenced by noise differences or differences from adult networks. Differential gene expression provided a potential explanation for the emergence of these networks and identified potential genes of interest for future research. This study revealed that neonatal connectomes can reveal individual-specific information processing units and has the potential to improve prediction of behavior and future outcomes.
Review
Obstetrics & Gynecology
Regina L. Triplett, Christopher D. Smyser
Summary: This review examines the relationship between intraventricular hemorrhage (IVH) in preterm infants and neurodevelopmental outcomes. It summarizes the latest neuroimaging techniques and their application in IVH infants, reviews studies on altered structural and functional connectivity, and discusses the link between infant findings and later childhood outcomes. Future directions for research and methodologic considerations are also discussed.
SEMINARS IN PERINATOLOGY
(2022)
Article
Neurosciences
Jungtak Park, Karolina Janacsek, Dezso Nemeth, Hyeon-Ae Jeon
Summary: This study used functional magnetic resonance imaging to investigate the whole-brain connectivity involved in statistical learning. The results showed that the activation strength in the superior frontal gyrus and other brain areas were related to statistical learning performance. The activations of the superior frontal network were most correlated with statistical learning performances. The functional connectivity between the superior frontal gyrus and brain regions involved in salience, language, and dorsal attention networks decreased during statistical learning.
Article
Multidisciplinary Sciences
Lilian M. N. Kebaya, Kevin Stubbs, Marcus Lo, Sarah Al-Saoud, Bradley Karat, Keith St Lawrence, Sandrine de Ribaupierre, Emma G. Duerden
Summary: Germinal Matrix-Intraventricular Hemorrhage (GMH-IVH) is a significant cause of adverse neurodevelopment in preterm infants. Reliable biomarkers are needed to aid in the early detection of posthemorrhagic ventricular dilatation (PHVD) and subsequent neurodevelopment. In a prospective cohort study, 3-dimensional (3D) cUS and functional near-infrared spectroscopy (fNIRS) were used to monitor neonates with GMH-IVH. Larger ventricle volumes (VV) were associated with decreased functional connectivity (sFC) in infants with severe GMH-IVH.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Pasquale Anthony Della Rosa, Matteo Canini, Elisa Marchetta, Sara Cirillo, Silvia Pontesilli, Roberta Scotti, Maria Grazia Natali Sora, Antonella Poloniato, Graziano Barera, Andrea Falini, Paola Scifo, Cristina Baldoli
Summary: Our study investigated the functional connectivity between Default Mode Network (DMN) and Executive Control Network (ECN) in preterm-born infants using rs-fMRI. We found the emergence of DMN in preterm neonates, with connectivity strength and synchronization increasing with biological maturity. Additionally, cognitive scores at 6 months were predicted by mPFC-ECN connectivity strength, with different patterns of ECN functional maturation observed for very early/early and moderate/late preterm neonates.
BRAIN AND COGNITION
(2021)
Article
Neurosciences
Kevin M. Cook, Josepheen De Asis-Cruz, Sudeepta K. Basu, Nickie Andescavage, Jonathan Murnick, Emma Spoehr, Adre J. du Plessis, Catherine Limperopoulos
Summary: This study provides the first direct investigation into the formation of functional brain architecture in preterm infants outside of the uterus. The results suggest that changes in functional architecture with increasing age exhibit a trajectory different from in utero fetuses, but more similar to the early postnatal period in term born infants.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Amelie Haugg, Rhodri Cusack, Laura E. Gonzalez-Lara, Bettina Sorger, Adrian M. Owen, Lorina Naci
FRONTIERS IN NEUROLOGY
(2018)
Article
Multidisciplinary Sciences
Lorina Naci, Amelie Haugg, Alex MacDonald, Mimma Anello, Evan Houldin, Shakib Naqshbandi, Laura E. Gonzalez-Lara, Miguel Arango, Christopher Harle, Rhodri Cusack, Adrian M. Owen
SCIENTIFIC REPORTS
(2018)
Article
Geriatrics & Gerontology
Juho M. Strommer, Simon W. Davis, Richard N. Henson, Lorraine K. Tyler, Cam-Can, Karen L. Campbell
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Delia Fuhrmann, David Nesbitt, Meredith Shafto, James B. Rowe, Darren Price, Andrew Gadie, Rogier A. Kievit, Lorraine K. Tyler, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, Meredith A. Shafto, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, David Samu, Jason R. Taylor, Matthias Treder, Kamen Tsvetanov, Janna van Belle, Nitin Williams, Lauren Bates, Tina Emery, Sharon Erzinlioglu, Sofia Gerbase, Stanimira Georgieva, Claire Hanley, Beth Parkin, David Troy, Tibor Auer, Marta Correia, Lu Gao, Emma Green, Rafael Henriques, Jodie Allen, Gillian Amery, Liana Amunts, Anne Barcroft, Amanda Castle, Cheryl Dias, Jonathan Dowrick, Melissa Fair, Hayley Fisher, Anna Goulding, Adarsh Grewal, Geoff Hale, Andrew Hilton, Frances Johnson, Patricia Johnston, Thea Kavanagh-Williamson, Magdalena Kwasniewska, Alison Mcminn, Kim Norman, Jessica Penrose, Fiona Roby, Diane Rowland, John Sargeant, Maggie Squire, Beth Stevens, Aldabra Stoddart, Cheryl Stone, Tracy Thompson, Ozlem Yazlik, Dan Barnes, Marie Dixon, Jaya Hillman, Joanne Mitchell, Laura Villis
NEUROBIOLOGY OF AGING
(2019)
Article
Neurosciences
Rita E. Loiotile, Rhodri Cusack, Marina Bedny
JOURNAL OF NEUROSCIENCE
(2019)
Article
Multidisciplinary Sciences
Rose Bruffaerts, Lorraine K. Tyler, Meredith Shafto, Kamen A. Tsvetanov, Alex Clarke, Carol Brayne, Edward T. Bullmore, Andrew C. Calder, Rhodri Cusack, Tim Dalgleish, John Duncan, Richard N. Henson, Fiona E. Matthews, William D. Marslen-Wilson, James B. Rowe, Karen Campbell, Teresa Cheung, Simon Davis, Linda Geerligs, Rogier Kievit, Anna McCarrey, Abdur Mustafa, Darren Price, David Samu, Jason R. Taylor, Matthias Treder, Janna van Belle, Nitin Williams, Lauren Bates, Tina Emery, Sharon Erzinclioglu, Andrew Gadie, Sofia Gerbase, Stanimira Georgieva, Claire Hanley, Beth Parkin, David Troy, Tibor Auer, Marta Correia, Lu Gao, Emma Green, Rafael Henriques, Jodie Allen, Gillian Amery, Liana Amunts, Anne Barcroft, Amanda Castle, Cheryl Dias, Jonathan Dowrick, Melissa Fair, Hayley Fisher, Anna Goulding, Adarsh Grewal, Geoff Hale, Andrew Hilton, Frances Johnson, Patricia Johnston, Thea Kavanagh-Williamson, Magdalena Kwasniewska, Alison McMinn, Kim Norman, Jessica Penrose, Fiona Roby, Diane Rowland, John Sargeant, Maggie Squire, Beth Stevens, Aldabra Stoddart, Cheryl Stone, Tracy Thompson, Ozlem Yazlik, Dan Barnes, Marie Dixon, Jaya Hillman, Joanne Mitchell, Laura Villis
SCIENTIFIC REPORTS
(2019)
Article
Psychology
Laura Cabral, Bobby Stojanoski, Rhodri Cusack
ATTENTION PERCEPTION & PSYCHOPHYSICS
(2020)
Article
Neurosciences
Jackson C. Liang, Jonathan Erez, Felicia Zhang, Rhodri Cusack, Morgan D. Barense
Article
Geriatrics & Gerontology
Noham Wolpe, James N. Ingram, Kamen A. Tsvetanov, Richard N. Henson, Daniel M. Wolpert, James B. Rowe
NEUROBIOLOGY OF AGING
(2020)
Article
Multidisciplinary Sciences
Kathy Y. Liu, Rogier A. Kievit, Kamen A. Tsvetanov, Matthew J. Betts, Emrah Duezel, James B. Rowe, Robert Howard, Dorothea Haemmerer
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Chiara Caldinelli, Rhodri Cusack
Summary: The fronto-parietal network (FPN) is considered crucial for cognitively demanding tasks, however, it is not necessarily the most flexible hub in the brain. It may only exhibit flexibility in specific task sets.
HUMAN BRAIN MAPPING
(2022)
Article
Behavioral Sciences
Elizabeth Musz, Rita Loiotile, Janice Chen, Rhodri Cusack, Marina Bedny
Summary: This study investigated the impact of life experiences on cortical function. In individuals who are born blind, the visual cortices can be recruited during nonvisual tasks. The study found that visual cortices have a latent capacity to respond to nonvisual information. This repurposing is particularly possible during the sensitive period of heightened plasticity in childhood.
Article
Neurosciences
Anna Truzzi, Rhodri Cusack
Summary: In humans, different brain regions have distinct timescales of information integration, and these timescales are related to cognitive performance and clinical symptoms. It is still not clear how these timescales develop. This study used resting state fMRI to investigate the timescales in newborns and adults. The results showed that newborns have longer timescales compared to adults, especially in unimodal regions, suggesting that these timescales act as an inductive bias and develop with experience. This initial slow approach might help infants to create more regularized and holistic representations of inputs, favoring the development of abstract and contextual representations.
Article
Gerontology
Meredith A. Shafto, Richard N. Henson, Fiona E. Matthews, Jason R. Taylor, Tina Emery, Sharon Erzinclioglu, Claire Hanley, James B. Rowe, Rhodri Cusack, Andrew J. Calder, William D. Marslen-Wilson, John Duncan, Tim Dalgleish, Carol Brayne, Lorraine K. Tyler
JOURNAL OF AGING AND HEALTH
(2020)
Article
Psychology, Developmental
Brea Chouinard, Kimberly Scott, Rhodri Cusack
INFANT BEHAVIOR & DEVELOPMENT
(2019)