期刊
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
卷 7, 期 6, 页码 -出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/cshperspect.a029835
关键词
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资金
- Swiss National Science Foundation
- European Research Council (ERC) Consolidator Grant [616830-MUSCLE_NET]
- Swiss Cancer Research Grant [KFS-3733-082015]
- Swiss Society for Research on Muscle Diseases (SSEM), SystemsX. ch
- Novartis Stiftung fur Medizinisch-Biologische Forschung
- University of Basel
- International PhD Program of the Biozentrum, University of Basel
Skeletal muscle is not only one of the largest, but also one of the most dynamic organs. For example, plasticity elicited by endurance or resistance exercise entails complex transcriptional programs that are still poorly understood. Various signaling pathways are engaged in the contracting muscle fiber and collectively culminate in the modulation of the activity of numerous transcription factors (TFs) and coregulators. Because exercise confersmany benefits for the prevention and treatment of a wide variety of pathologies, pharmacological activation of signaling pathways and TFs is an attractive avenue to elicit therapeutic effects. Members of the nuclear receptor (NR) superfamily are of particular interest owing to the presence of well-defined DNA-and ligand-binding domains. In this review, we summarize the current understanding of the involvement of NRs in muscle biology and exercise adaptation.
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