Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Ophthalmology
Arantxa Acera, Beatriz Abad, Xandra Pereiro, Francisco David Rodriguez, Noelia Ruzafa, Juan Antonio Duran, Elena Vecino
Summary: The tear film lipid layer (TFLL) plays a crucial role in maintaining high-quality vision, protecting the cornea, and promoting wound healing. Plasma rich in growth factor (PRGF) eye drops have emerged as a new treatment for aqueous deficient dry eye. This study compared the lipid profiles of PRGF eye drops with tears and found that the lipids in PRGF eye drops could be used as a supplement for altered tear lipid composition.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Ophthalmology
Naeimeh Monfared, Paul J. Murphy
Summary: Tear evaporation is a normal physiological process that regulates blink activity and tear production. Altered tear evaporation rate (TER) is a defining characteristic of evaporative dry eye disease (DED) and serves as a useful clinical diagnostic test. Understanding the normal range of TER, influenced by ocular, environmental and systemic factors, is crucial for improved disease diagnosis.
CONTACT LENS & ANTERIOR EYE
(2023)
Review
Biology
Norihiko Yokoi, Petar Eftimov, Georgi As. Georgiev
Summary: Soft contact lenses cause disturbances in the connection between the pre-lens tear film and the ocular surface, resulting in dry eye and discomfort. Factors such as decreased tear meniscus radius, attenuated spread of tear film lipid layer, limited wettability of contact lens surface, and increased friction with eyelid wiper contribute to these issues. This review examines the contributions of these factors to tear film breakup patterns and contact lens discomfort from a clinical and basic science perspective.
Article
Medicine, General & Internal
Wan-Lin Wu, Shu-Wen Chang
Summary: This study aimed to investigate the relationships between subjective symptoms, objective signs, and dermatochalasis severity in dry-eye patients and the effects of lid hygiene on dry-eye parameters. The results showed that patients with more severe dermatochalasis had less severe symptoms and poorer meibomian gland expressibility, higher meiboscale grades, and thicker lipid-layer thickness. Lid hygiene significantly improved subjective symptoms, lipid-layer thickness, and aqueous tear secretion, particularly in patients with less severe dermatochalasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Safal Khanal, Yuqiang Bai, William Ngo, Kelly K. Nichols, Landon Wilson, Stephen Barnes, Jason J. Nichols
Summary: The study found that some human meibum-derived OAHFAs were significantly associated with precorneal tear film thinning, potentially related to eye health. However, tear film-derived OAHFAs showed no association with the rate of precorneal tear film thinning.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Keisuke Watanabe, Masataka Yoshida, Takashi Okumura, Takayuki Sassa, Akio Kihara, Akira Uchiyama
Summary: This study evaluated the efficacy of a mineral oil-containing ophthalmic solution in mitigating evaporative dry eye symptoms in a mouse model with disrupted fatty acid elongase Elovl1. The results showed that mineral oil was effective in improving dry eye symptoms. This research provides new insights into the treatment of dry eye disease.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Yilin Song, Sile Yu, Xingru He, Lanting Yang, Yi Wu, Guanghao Qin, Qing Zhang, Gagan Deep Singh Talwar, Ling Xu, Jonathan E. Moore, Wei He, Emmanuel Eric Pazo
Summary: The study shows that intense pulsed light (IPL) treatment using optimal pulse light technology (OPT) can improve tear film lipid layer (TFLL) quality in patients with evaporative dry eye (EDE), reducing symptoms and the frequency of artificial tear use.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Multidisciplinary Sciences
Ching-Jen Hsiao, Hsiao-Ching Tung, Chuen-Lin Tien, Yu-Wen Chang, Ching-Ying Cheng
Summary: This study investigated the impact of large-diameter multifocal contact lenses on the ocular surface, visual quality, and visual function for presbyopic adults with dry eye syndromes. The results showed that while these lenses had a negative effect on the ocular surface and tear film, they significantly improved visual function and visual quality.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Hsin-Yu Weng, Wei-Ting Ho, Chiung-Yi Chiu, Tzu-Yun Tsai, Shu-Wen Chang
Summary: The study found that younger patients with dry eye disease (DED) had more severe subjective symptoms, higher SPEED and OSDI scores, thinner LLT, lower extent of meibomian gland dropout, and more blinks compared to older patients. This may be due to less impact on the structure and function of the meibomian glands in younger patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Ophthalmology
Yi Wu, Ling Xu, Yilin Song, Qing Zhang, Guanghao Qin, Lanting Yang, Jinfei Ma, Christoph Palme, Jonathan E. Moore, Emmanuel Eric Pazo, Wei He
Summary: This study aimed to evaluate and compare the effects of IPL and 0.1% SH alone and in combination with HEM on patients with persistent post-LASIK DE. The results showed that the combination of IPL, SH, and HEM had a significant improvement on the symptoms and signs of dry eye in these patients.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Pharmacology & Pharmacy
Kamila Riedlova, Maria Chiara Saija, Agnieszka Olzynska, Katarina Vazdar, Philippe Daull, Jean-Sebastien Garrigue, Lukasz Cwiklik
Summary: The tear film lipid layer (TFLL) may serve as a reservoir for latanoprost, facilitating its prolonged release and potentially optimizing glaucoma treatment. These findings have significant implications for the development of new drug delivery systems targeting the TFLL.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Saki Sakakura, Emi Inagaki, Yuichiro Ochiai, Masatoshi Yamamoto, Naofumi Takai, Taeko Nagata, Kazunari Higa, Yasunori Sato, Hiroshi Toshida, Dogru Murat, Masatoshi Hirayama, Yoko Ogawa, Kazuno Negishi, Shigeto Shimmura
Summary: The tear film stability of a rabbit dry eye model induced by dacryoadenectomy was assessed in this study. The results showed that this model partially captured the phenotypes of human short TBUT-type dry eye, making it a potentially useful animal model for investigating potential drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Tuomo Viitaja, Jukka Moilanen, Kirsi Johanna Svedstrom, Filip S. Ekholm, Riku O. Paananen
Summary: The study found that the interaction of different tear film lipid species can improve the evaporation resistance, potentially paving the way for improved dry eye treatments and other applications where water evaporation is a challenge.
Review
Chemistry, Multidisciplinary
Joon Young Hyon, Sang Beom Han
Summary: Dry eye disease is a global public health problem that impairs quality of life and poses economic burden. Inflammation plays a key role in the worsening of the disease, and besides anti-inflammatory medications, vitamin supplementation may also be effective.
APPLIED SCIENCES-BASEL
(2022)
Article
Ophthalmology
Paramdeep Bilkhu, Zimar Sivardeen, Connie Chen, Jennifer P. Craig, Kylie Mann, Michael T. M. Wang, Saleel Jivraj, Karim Mohamed-Noriega, David E. Charles-Cantu, James S. Wolffsohn
Summary: The purpose of this study was to explore how patients in different countries manage their dry eye symptoms. The results showed that there were differences in the duration and severity of symptoms between countries, but no significant difference in the impact of symptoms on quality of life. However, few people consulted healthcare professionals and only about half of the respondents tried treatment options.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Cardiac & Cardiovascular Systems
Yi-Wen (Becky) Liao, Tom Kai Ming Wang, Michael Tzu Min Wang, Tharumenthiran Ramanathan, Miriam Wheeler
Summary: This study compared mitral valve repair and replacement in patients with rheumatic heart disease and found that mitral valve repair is associated with a reduction in operative and long-term mortality and bleeding, but it does entail a higher rate of reoperation during follow-up.
HEART LUNG AND CIRCULATION
(2022)
Article
Ophthalmology
William Shew, Alex Muntz, Simon J. Dean, Heiko Pult, Michael T. M. Wang, Jennifer P. Craig
Summary: Incomplete blinking and sagittal lid misalignment of the central eyelid margin are predominant in habitual blinking, regardless of lid morphology.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Michael T. M. Wang, Rachael L. Niederer, Charles N. J. McGhee, Helen Danesh-Meyer
Summary: This article provides a summary of the latest evidence on COVID-19 vaccine-associated ocular adverse events through a narrative literature review. The data suggest that vaccination-associated ocular adverse events are very rare, and there is no evidence to suggest any negative effects of COVID-19 immunization in patients with pre-existing ophthalmic conditions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
William K. Diprose, Catherine A. Morgan, Michael T. M. Wang, James P. Diprose, Joanne C. Lin, Sulaiman Sheriff, Doug Campbell, P. Alan Barber
Summary: Active conductive head cooling can significantly reduce brain temperature, with the occipital lobes showing the greatest reduction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Review
Clinical Neurology
William Shew, Michael T. M. Wang, Helen V. Danesh-Meyer
Summary: A systematic review and meta-analysis showed that the risk of NAION after cataract surgery is four times higher within the first year and mostly occurs within 6 months. However, the absolute risk is low, with 1 in 1,000-3,100 surgeries, and does not require extra mention during consent.
JOURNAL OF NEURO-OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Sophie Speakman, Michael T. M. Wang, Alex Muntz, Maria Vidal-Rohr, Francesco Menduni, Sandeep Dhallu, Tugce Ipek, Duygu Acar, Alberto Recchioni, Alex France, Alec Kingsnorth, James S. Wolffsohn, Jennifer P. Craig
Article
Multidisciplinary Sciences
Jay J. Meyer, Akilesh Gokul, Michael T. M. Wang, Justin Sung, Jennifer P. Craig
Summary: Persistent changes in the ocular surface and tear film can occur after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK), including increased fluorescein staining, decreased tear film breakup time, decreased corneal sub-basal nerve density, and reduced corneal sensitivity.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Jennifer P. Craig, Etty Bitton, Jaya Dantam, Lyndon Jones, William Ngo, Michael T. M. Wang
Summary: This study evaluated the short-term tolerability of five commercially available anti-demodectic eyelid cleansers, finding that different cleanser formulations may induce ocular discomfort, tear film instability, conjunctival hyperaemia, and ocular surface staining during application.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Ophthalmology
Anat Galor, Alexis Ceecee Britten-Jones, Yun Feng, Giulio Ferrari, David Goldblum, Preeya K. Gupta, Jesus Merayo-Lloves, Kyung-Sun Na, Shehzad A. Naroo, Kelly K. Nichols, Eduardo M. Rocha, Louis Tong, Michael T. M. Wang, Jennifer P. Craig
Summary: Various factors in mental, physical, and social health domains have been linked to ocular surface diseases, particularly dry eye disease (DED). Mental health factors such as depression and anxiety, and medications used to treat them, have been associated with DED symptoms. Sleep disorders and physical health issues like obesity and face mask wear have also been linked to DED. Societal factors, such as tobacco use, cocaine, and alcohol, have been associated with tear instability, decreased corneal sensitivity, and tear film disturbances and DED symptoms, respectively.
Review
Ophthalmology
Daniel A. R. Scott, Michael T. M. Wang, Helen Danesh-Meyer, Sarah Hull
Summary: Optic atrophy is a significant cause of visual impairment in children, and the underlying causes have changed over time. Prematurity has become an increasingly common cause of optic atrophy, likely due to the rising rates of premature births and improved survival of preterm infants. However, there is limited research on this topic with small sample sizes and methodological limitations, calling for larger, better-designed studies to understand the contribution of prematurity to the disease burden. Screening for prematurity should be considered when evaluating pediatric optic atrophy, alongside other potential life-threatening causes.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2023)
Editorial Material
Ophthalmology
Michael T. M. Wang, Alexis Ceecee Britten-Jones, Jennifer P. Craig
JAMA OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Cameron Schauer, Joshua Quon, Pravin Potdar, Ashwin Singh, Dean Croft, Michael Wang
Summary: This study aimed to compare alcohol-related hospital presentations during the COVID-19 restriction periods in New Zealand with corresponding control periods from the previous year. The results showed that there was no change in alcohol-related presentations during the strictest lockdown period, but there was a higher proportion of acute mental and behavioral disorders. New Zealand appears to have avoided the general trend of increased alcohol-related harms seen internationally during the COVID-19 pandemic and its lockdown restrictions.
NEW ZEALAND MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Bhavesh Dayal Lallu, Jae Beom Hong, Michael Wang, John Chalissery, Roger Blume, Jeanette Langridge, Sarah Davidson, Heather Webb, P. Alan Barber
Summary: This study compares the process metrics and outcomes of patients transferred for stroke clot retrieval (SCR) from regional and metropolitan areas to Auckland City Hospital. The results indicate that regional patients can achieve similar SCR outcomes to metropolitan patients.
NEW ZEALAND MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Cameron Schauer, Michael Chieng, Michael Wang, Michelle Neave, Sarah Watson, Marius Van Rijnsoever, Russell Walmsley, Ali Jafer
Summary: AI-assisted colonoscopy significantly improved adenoma detection rate compared with conventional colonoscopy, while there was no significant difference in overall polyp detection rate. However, further research is needed to understand its impact on long-term clinical outcomes.
NEW ZEALAND MEDICAL JOURNAL
(2022)
