Article
Biochemistry & Molecular Biology
Xueting Xu, Tanveer Ahmed, Lulu Wang, Xintao Cao, Zeyu Zhang, Ming Wang, Yuan Lv, Shahzina Kanwal, Muqddas Tariq, Runxia Lin, Hui Zhang, Yinghua Huang, Hao Peng, Danni Lin, Xue Shi, Didi Geng, Baohua Liu, Xiaofei Zhang, Wen Yi, Yan Qin, Miguel A. Esteban, Baoming Qin
Summary: The study demonstrates the role of mTORC1 in regulating paused pluripotency in mESCs, and reveals a context-dependent function of eIF4F in translating pluripotency genes in SL and 2iL culture conditions.
Article
Cell Biology
Menghao You, Jingjing Liu, Jie Li, Ce Ji, Haochen Ni, Wenhui Guo, Jiarui Zhang, Weiwei Jia, Zhao Wang, Yajiao Zhang, Yingpeng Yao, Guotao Yu, Huanyu Ji, Xiaohu Wang, Dali Han, Xuguang Du, Meng Michelle Xu, Shuyang Yu
Summary: The study reveals that Mettl3, an N6-methyladenosine (m6A) methyltransferase, is involved in innate immune cell regulation. It shows that Mettl3 intrinsically controls the development and function of invariant natural killer T (iNKT) cells through m6A-dependent mechanisms. Deficiency of Mettl3 disrupts the expression of iNKT cell-related genes and alters m6A modification, leading to impairments in proliferation, differentiation, and cytokine secretion of iNKT cells. The study also identifies Creb1 as a key downstream target of Mettl3, and ectopic expression of Creb1 can rescue the developmental defects in Mettl3-deficient iNKT cells.
Article
Multidisciplinary Sciences
Andreas Lackner, Michael Mueller, Magdalena Gamperl, Delyana Stoeva, Olivia Langmann, Henrieta Papuchova, Elisabeth Roitinger, Gerhard Duernberger, Richard Imre, Karl Mechtler, Paulina A. A. Latos
Summary: The Erf-NCoR1/2 complex controls trophoblast differentiation by linking signalling with transcriptional repression.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Shuang-Feng Zhang, Shang-Kun Dai, Hong-Zhen Du, Hui Wang, Xing-Guo Li, Yi Tang, Chang-Mei Liu
Summary: This study demonstrates that the loss of EED affects embryonic brain development, resulting in a decrease in the number of upper-layer neurons. Further analysis reveals altered epigenetic states of cortical neurogenesis-related genes in the absence of Eed, and the switching from H3K27me3 to H3K27ac promotes neuronal expression.
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Itishree Kaushik, Sanjay K. Srivastava
Summary: In this study, moxidectin, a GABAA receptor agonist, was found to inhibit the proliferation of Sonic hedgehog-activated subgroup of medulloblastoma (SHH-MB) cells by inducing apoptosis. Moxidectin also suppressed the expression of related signaling pathways and cancer stem cell molecules. In mouse models, oral administration of moxidectin significantly suppressed the growth of SHH-MB tumors. These findings suggest that moxidectin may be a potential therapeutic option for treating SHH-MB patients.
Article
Immunology
Zengdi Zhang, Oscar C. Salgado, Bing Liu, Zahra Moazzami, Kristin A. Hogquist, Michael A. Farrar, Hai-Bin Ruan
Summary: This article investigates the role of the O-GlcNAc transferase (OGT)-STAT5 axis in regulating the immunomodulatory function and metabolic homeostasis of Treg cells. The results show that OGT deficiency in Treg cells makes mice more susceptible to high-fat diet-induced obesity and insulin resistance, while constitutive STAT5 activation in Treg cells protects against adipose tissue expansion and impaired glucose and insulin metabolism. Targeting the OGT-STAT5 axis can enhance Treg cell function to combat obesity and related metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao, Zhaocai Zhou
Summary: The MST4-p beta-catenin(Thr40) signaling axis is essential for intestinal stem cell homeostasis and CRC development, preventing beta-catenin degradation and leading to its accumulation and activation. Enhanced MST4 activity exacerbates CRC progression, suggesting potential for targeted therapy.
Article
Geriatrics & Gerontology
Ji-Hoon Kim, Inkuk Park, Hijai R. Shin, Joonwoo Rhee, Ji-Yun Seo, Young-Woo Jo, Kyusang Yoo, Sang-Hyeon Hann, Jong-Seol Kang, Jieon Park, Ye Lynne Kim, Ju-Yeon Moon, Man Ho Choi, Young-Yun Kong
Summary: Disrupting the HPG axis impairs muscle regeneration, increases DNA damage marker expression and senescence-related gene expression in MuSCs, indicating that the absence of sex hormone signaling accelerates the aging process of MuSCs.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Cell Biology
Sahar Tavakoli, Vivian Garcia, Eric Gahwiler, Isaac Adatto, Apoorva Rangan, Kathleen A. Messemer, Sara Ashrafi Kakhki, Song Yang, Victoria S. Chan, Margot E. Manning, Haleh Fotowat, Yi Zhou, Amy J. Wagers, Leonard I. Zon
Summary: Stem cell transplantation is a potential cure for genetic disorders of skeletal muscle, but is currently limited by cell expansion and poor engraftment efficiency. In this study, a cross-species small-molecule screening platform using zebrafish and mice was developed to identify molecules that enhance myogenic activity and muscle engraftment. Two lipids, lysophosphatidic acid and niflumic acid, were found to promote muscle engraftment in both species by activating intracellular calcium-ion flux.
Article
Cell Biology
Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang, Yi-Zhe Ren, Xian-Zhou Zhang, Lei Wu, Wen-Li Qian, Qiao-Mei Guo, Wan-Xing Xu, Xue-Qing Wang, Fei Wu, Lin Wang, Yutong Gu, Mo-Fang Liu, Jia-Tao Lou
Summary: Bone metastasis is a significant complication in lung cancer patients, leading to poor quality of life and low survival rates. The regulatory mechanisms of lung cancer bone metastasis are not well understood. A study found that miR-182 plays a critical role in promoting osteoclastic metastasis of lung cancer cells. Mechanistically, miR-182 enhances the secretion of Interleukin-8 (IL-8) by NSCLC cells, which in turn activates STAT3 signaling in osteoclast progenitor cells to promote osteoclastogenesis. Inhibition of IL-8 with antibodies effectively suppresses NSCLC bone metastasis in animal models. These findings highlight the importance of the miR-182/IL-8/STAT3 axis as a potential therapeutic target for interrupting lung cancer bone metastasis.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Clement Larrue, Nathan Guiraud, Pierre-Luc Mouchel, Marine Dubois, Thomas Farge, Mathilde Gotanegre, Claudie Bosc, Estelle Saland, Marie-Laure Nicolau-Travers, Marie Sabatier, Nizar Serhan, Ambrine Sahal, Emeline Boet, Sarah Mouche, Quentin Heydt, Nesrine Aroua, Lucille Stuani, Tony Kaoma, Linus Angenendt, Jan-Henrik Mikesch, Christoph Schliemann, Francois Vergez, Jerome Tamburini, Christian Recher, Jean-Emmanuel Sarry
Summary: The study reveals the critical role of ADM-CALCRL in post-chemotherapy persistence of drug-tolerant leukemic stem cells, suggesting it as a promising therapeutic target to prevent relapse in AML. Targeting adrenomedullin-calcitonin receptor-like receptor reduces the frequency of relapse-initiating cells and improves chemotherapy response in AML preclinical models.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Jin Li, Tingting Yang, Haifei Tang, Zhao Sha, Rui Chen, Lei Chen, Yan Yu, Glenn C. Rowe, Saumya Das, Junjie Xiao
Summary: lncMAAT is identified as a common regulator of skeletal muscle atrophy, which is downregulated in multiple models and can ameliorate muscle atrophy by negatively regulating miR29b and positively regulating Mbnl1 expression. Overexpression of lncMAAT may represent a promising therapy for muscle atrophy induced by different stimuli.
Article
Biochemistry & Molecular Biology
Bradley R. Groveman, Benjamin Schwarz, Eric Bohrnsen, Simote T. Foliaki, James A. Carroll, Aleksandar R. Wood, Catharine M. Bosio, Cathryn L. Haigh
Summary: The absence of PrP protein inhibits the growth pathways of neural stem cells, resulting in decreased proliferation and increased senescence. This effect may be related to changes in the EGFR signaling pathway, decreased mitochondrial function, and blockages in cellular energy pathways.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Cell Biology
Rajiv L. Tiwari, Pratibha Mishra, Nicola Martin, Nikhil Oommen George, Vadim Sakk, Karin Soller, Kodandaramireddy Nalapareddy, Kalpana Nattamai, Karin Scharffetter-Kochanek, Maria Carolina Florian, Hartmut Geiger
Summary: As aging progresses, hair regeneration is impaired due to changes in the signaling pathways of HFSCs, such as a shift from canonical to non-canonical Wnt signaling. However, treatment with a specific pharmacological inhibitor can restore the functional deficits in aged HFSCs.