Article
Immunology
John Baker, Kristina Seiffert-Sinha, Animesh A. Sinha
Summary: This study found that HLA genotype, ethnicity, and antibody levels are correlated with the types of lesions in patients with pemphigus vulgaris. The findings highlight the impact of genetic factors on disease development and provide insights for improved clinical management strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ji An Kang, Yoon Jung Kim, Young Joo Jeon
Summary: ISG15, a ubiquitin-like protein found only in vertebrates, plays diverse roles in cellular processes and has potential therapeutic implications in human diseases, including cancer. However, the mechanisms and consequences of ISG15 and its conjugation remain poorly understood.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Chemistry, Analytical
Douwe Schulte, Weiwei Peng, Joost Snijder
Summary: Antibodies have the ability to target a diverse range of antigens by generating complementary sequences through somatic recombination and hypermutation. Understanding the antibody repertoire requires specific sequencing methods. Mass spectrometry-based methods offer a way to bridge the gap between antibody repertoire profiling and serological assays. Researchers have developed a software tool called Stitch that can be used for sequencing monoclonal and polyclonal antibody repertoires, and its application has been demonstrated in various experiments.
ANALYTICAL CHEMISTRY
(2022)
Article
Clinical Neurology
Abdus Samad Ansari, Jelle Vehof, Christopher J. Hammond, Fion D. Bremner, Katie M. Williams
Summary: Genetic factors play a key role in determining resting pupil size and reactivity, with heritability estimated at 86% for pupil size and various pupillary reactions. Age was found to be associated with pupil size and light reaction, while iris color, intraocular pressure, and refractive error showed no significant association with pupil characteristics in this study.
FRONTIERS IN NEUROLOGY
(2021)
Article
Rheumatology
Emma C. de Moel, Leendert A. Trouw, Chikashi Terao, Nimmisha Govind, Mohammed Tikly, Hani El-Gabalawy, Irene Smolik, Holger Bang, Tom W. J. Huizinga, Rene E. M. Toes, Diane van der Woude
Summary: Rheumatoid arthritis (RA) occurs in different ethnic populations worldwide. This study revealed that anti-modified protein antibodies (AMPA) can be detected in RA patients across different continents and ethnicities, suggesting a common pathway involved in AMPA development. However, differences in AMPA levels and associated factors were observed among the different populations.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Dermatology
Khalaf Kridin, Christoph M. Hammers, Ralf J. Ludwig, Erez Onn, Yochai Schonmann, Abed Abu-Elhija, Dana Tzur Bitan, Enno Schmidt, Orly Weinstein, Arnon D. Cohen
Summary: There is a bidirectional association between bullous pemphigoid (BP) and atopic dermatitis (AD) and allergic rhinitis (AR). A history of AD and AR increases the risk of developing BP, while BP patients are at an increased risk of subsequent AD. BP patients with comorbid AD and AR are more likely to be managed with drugs and corticosteroids, and have reduced all-cause mortality.
Article
Multidisciplinary Sciences
Jagadish C. Ghosh, Michela Perego, Ekta Agarwal, Irene Bertolini, Yuan Wang, Aaron R. Goldman, Hsin-Yao Tang, Andrew Kossenkov, Catherine J. Libby, Lucia R. Languino, Edward F. Plow, Annamaria Morotti, Luisa Ottobrini, Marco Locatelli, David W. Speicher, M. Cecilia Caino, Joel Cassel, Joseph M. Salvino, Marie E. Robert, Valentina Vaira, Dario C. Altieri
Summary: The study reveals that many human tumors have reduced levels of Mic60, an essential scaffold of mitochondrial structure, which leads to the disruption of mitochondrial integrity. Surprisingly, these tumors show decreased cell proliferation, resistance to cell death, and activation of a gene expression program related to innate immunity and cytokine/chemokine signaling. This process induces epithelial-mesenchymal transition, tumor cell movement, and promotes metastatic dissemination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Dermatology
Katharina Boch, Ewan A. Langan, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Christoph M. Hammers
ACTA DERMATO-VENEREOLOGICA
(2022)
Letter
Dermatology
Pauleatha Diggs Bonds, Joyce Huang, Jacqueline Ike, Eric Mukherjee, Lynn Petukhova, Lee Wheless
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ankit Chhoda, Ziga Vodusek, Kapil Wattamwar, Eric Mukherjee, Craig Gunderson, Alyssa Grimshaw, Anup Sharma, Nita Ahuja, Fay Kastrinos, James J. Farrell
Summary: This study quantified the occurrence of late-stage pancreatic ductal adenocarcinoma (PDAC) during surveillance of high-risk individuals (HRIs) and found that their incidence was not associated with baseline clinicoradiologic features. Further research on stage-based outcomes is needed to improve HRI surveillance.
Article
Dermatology
Christian D. Sadik, Hanan Rashid, Christoph M. Hammers, Gilles F. H. Diercks, Anke Weidinger, Stefan Beissert, Franziska Schauer, James Fettiplace, Diamant Thaci, Yenting Ngai, Miles A. Nunn, Detlef Zillikens, Barbara Horvath
Summary: This study suggests that nomacopan may be well tolerated by older patients with bullous pemphigoid and could have therapeutic benefits in suppressing acute flares of the disease. Further research is needed to confirm its safety profile and establish nomacopan as a new treatment option for bullous pemphigoid.
Editorial Material
Allergy
Eric M. Mukherjee, Elizabeth J. Phillips
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Editorial Material
Dermatology
Khalaf Kridin, Christoph M. Hammers
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Oncology
Evgenii N. Tcyganov, Emilio Sanseviero, Douglas Marvel, Thomas Beer, Hsin-Yao Tang, Peter Hembach, David W. Speicher, Qianfei Zhang, Laxminarasimha R. Donthireddy, Ali Mostafa, Sabina Tsyganova, Vladimir Pisarev, Terri Laufer, Dmitriy Ignatov, Soldano Ferrone, Christiane Meyer, Helene Maby-El Hajjami, Daniel E. Speiser, Sooner Altiok, Scott Antonia, Xiaowei Xu, Wei Xu, Cathy Zheng, Lynn M. Schuchter, Ravi K. Amaravadi, Tara C. Mitchell, Giorgos C. Karakousis, Zhe Yuan, Luis J. Montaner, Esteban Celis, Dmitry Gabrilovich
Summary: This study found that the oxidant peroxynitrite (PNT) can alter the profile of MHC-I bound peptides presented on tumor cells. Only cytotoxic cells targeting PNT-resistant peptides have an anti-tumor effect, while those targeting PNT-sensitive peptides are ineffective. Targeting PNT in mice reduces tumor cell resistance to cytotoxic cells. Melanoma patients with low PNT activity in their tumors respond better to immunotherapy.
Article
Immunology
Gauri Mirji, Alison Worth, Sajad Ahmad Bhat, Mohamed El Sayed, Toshitha Kannan, Aaron R. Goldman, Hsin-Yao Tang, Qin Liu, Noam Auslander, Chi Dang, Mohamed Abdel-Mohsen, Andrew Kossenkov, Ben Z. Stanger, Rahul S. Shinde
Summary: The gut microbe-derived metabolite TMAO enhances antitumor immunity in pancreatic ductal adenocarcinoma (PDAC) by promoting an immunostimulatory tumor-associated macrophage (TAM) phenotype and activating effector T cell response. TMAO exerts antitumor effects through potentiating the type I interferon pathway.
SCIENCE IMMUNOLOGY
(2022)
Biographical-Item
Dermatology
Christoph M. Hammers
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Allergy
Andrew Gibson, Pooja Deshpande, Chelsea N. Campbell, Matthew S. Krantz, Eric Mukherjee, Maja Mockenhaupt, Munir Pirmohamed, Amy M. Palubinsky, Elizabeth J. Phillips
Summary: Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), have significant impact on health and hinder drug development. Understanding the association between HLA class I alleles and SCARs has helped with prevention efforts and shed light on the immunopathogenesis. However, there is still much unknown about the specific risk alleles and antigens involved. Identifying the MHC-restricted drug-reactive peptides and genetic/environmental risk factors will be crucial for predicting individual and drug-level risks and developing targeted therapeutics.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minjeong Yeon, Irene Bertolini, Ekta Agarwal, Jagadish C. Ghosh, Hsin-Yao Tang, David W. Speicher, Frederick Keeney, Khalid Sossey-Alaoui, Elzbieta Pluskota, Katarzyna Bialkowska, Edward F. Plow, Lucia R. Languino, Emmanuel Skordalakes, M. Cecilia Caino, Dario C. Altieri
Summary: In this study, it is found that the altered ubiquitination ligase Parkin in Parkinson's disease forms a complex with the regulator of cell motility Kindlin-2 at mitochondria of tumor cells. Parkin ubiquitinates Kindlin-2 leading to its proteasomal degradation, which inhibits tumor cell interactions with the extracellular matrix, migration, and invasion. However, Parkin does not affect tumor cell proliferation, cell cycle transitions, or apoptosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Brittany MacTaggart, Marie Shimogawa, Marshall Lougee, Hsin-Yao Tang, E. J. Petersson, Anna Kashina
Summary: This study reports the first global screen for side-chain arginylation and generates and validates panarginylation antibodies for detecting side-chain arginylation in any amino acid sequence context. The study identifies a limited set of proteins that likely undergo ATE1-dependent side-chain arginylation and are enriched in specific cellular roles.
MOLECULAR & CELLULAR PROTEOMICS
(2023)
Article
Oncology
Simona Lombardi, Aaron R. Goldman, Hsin-Yao Tang, Andrew Kossenkov, Heng Liu, Wei Zhou, Meenhard Herlyn, Jianhuang Lin, Rugang Zhang
Summary: The arginine methyltransferase CARM1 is highly expressed in various human cancers, including ovarian cancer, but therapeutic approaches for tumors overexpressing CARM1 have not been studied. This study found that CARM1 promotes monounsaturated fatty acid synthesis and targeting the fatty acid reprogramming pathway can be a potential therapeutic strategy for CARM1-expressing ovarian cancers.
CANCER RESEARCH COMMUNICATIONS
(2023)
