期刊
CELL REPORTS
卷 21, 期 10, 页码 2879-2894出版社
CELL PRESS
DOI: 10.1016/j.celrep.2017.11.019
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资金
- MRC [SNCF G0802010]
- Wellcome Trust [103717/Z/14/Z]
- Marie Sklodowska-Curie Postdoctoral Fellowship [702337]
- MRC LMCB [MC_U12266B]
- Medical Research Council [MC_U12266B, MC_CF12266] Funding Source: researchfish
Spatiotemporal regulation of gene expression depends on the cooperation of multiple mechanisms, including the functional interaction of promoters with distally located enhancers. Here, we show that, in cortical neurons, a subset of short interspersed nuclear elements (SINEs) located in the proximity of activity-regulated genes bears features of enhancers. Enhancer SINEs (eSINEs) recruit the Pol III cofactor complex TFIIIC in a stimulus-dependent manner and are transcribed by Pol III in response to neuronal depolarization. Characterization of an eSINE located in proximity to the Fos gene (Fos(RSINE1)) indicated that the Fos(RSINE1)-encoded transcript interacts with Pol II at the Fos promoter and mediates Fos relocation to Pol II factories, providing an unprecedented molecular link between Pol III and Pol II transcription. Strikingly, knockdown of the Fos(RSINE1) transcript induces defects of both cortical radial migration in vivo and activity-dependent dendritogenesis in vitro, demonstrating that Fos(RSINE1) acts as a strong enhancer of Fos expression in diverse physiological contexts.
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