Article
Oncology
Qingli Kong, Hui Wang, Xiaolei Ren, Yue Zhuo, Jing Peng
Summary: This study evaluated the risk of myasthenia gravis (MG) associated with immune checkpoint inhibitors (ICI) and identified correlations between six drugs and three adverse events through analysis of FAERS data. The findings suggest that ICIs may lead to ICIs-associated MG during therapy. Practitioners should consider the factors that may increase the likelihood of MG.
Article
Pharmacology & Pharmacy
Louis Letinier, Amandine Ferreira, Alexandre Marceron, Marina Babin, Joelle Micallef, Ghada Miremont-Salame, Antoine Pariente
Summary: The study found that hemorrhage was the most common clinical manifestation of serious adverse drug reactions resulting from drug-drug interactions reported in France, followed by renal failure, pharmacokinetic alteration, and cardiac arrhythmias. More than one-third of serious adverse drug reactions involved at least three drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Antonio Vallano, Caridad Pontes, Antonia Agusti
Summary: The European Medicines Agency (EMA) has accelerated procedures and relaxed authorization requirements to provide access to innovative medicines for diseases with unmet medical needs. However, this has led to increased uncertainty about the efficacy and safety of these medicines, which has implications for clinical practice and pricing negotiations. Balancing timely access to new treatments with evidence-based decision-making and fair pricing is crucial but challenging. Rating: 7/10.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Leila Abou Salha, Flavia Costa Reis, Roberta Moreira Goncalves, Jordao Horacio da Silva Lima, Nadia Abou Salha, Roney Pereira Pinto, Jose Elmo de Menezes, Eduardo Perez Oliveira, Pedro Lopes Ferreira, Maria Alves Barbosa
Summary: The increase in access to oncological medicines through court cases raises concerns about the constitutional guarantees of integral and universal care in the Brazilian public health system. The study found that women accounted for a significant portion of the lawsuits, with most cases filed by individuals over 55 years old with low income. Non-official oncological medicines were the most frequently requested drugs.
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2022)
Article
Oncology
Kohei Somekawa, Nobuyuki Horita, Ayami Kaneko, Yoichi Tagami, Nobuhiko Fukuda, Hiromi Matsumoto, Ho Namkoong, Yu Fujiwara, Kaoru Minegishi, Takeshi Fukumoto, Keisuke Watanabe, Yu Hara, Nobuaki Kobayashi, Takeshi Kaneko
Summary: This study found that the combination of nivolumab and ipilimumab (N3I1) induced fewer adverse events (AEs), grade 3 or higher AEs, and serious AEs compared to the alternative dosage combination (N1I3).
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yiran Chen, Lei Wei, Yu Song, Rui Zhang, Le Kuai, Bin Li, Ruiping Wang
Summary: This study aimed to explore the association between life quality based on the Dermatology Life Quality Index (DLQI) evaluation and disease severity among psoriasis patients in China. The study found that life quality based on DLQI evaluation was positively correlated with disease severity, especially among male patients and those with higher body mass index (BMI). Therefore, it is recommended that clinicians consider DLQI evaluation as an important indicator during patient treatment.
ANNALS OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Gabor Ruzsa, Fanni Rencz, Valentin Brodszky
Summary: This study developed an experimental value set for the Dermatology Life Quality Index (DLQI) by examining the relationship between time trade-off (TTO) utility valuations and DLQI severity levels characterizing dermatologically relevant health states. The study found that the social/interpersonal consequences of skin conditions had a larger impact on valuations compared to the physical/practical aspects, and there was significant heterogeneity across DLQI items.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Review
Medicine, General & Internal
Yudisia Ausi, Prayudi Santoso, Deni Kurniadi Sunjaya, Melisa Intan Barliana
Summary: This article reviewed the burden of adverse drug reactions (ADR) among drug-resistant tuberculosis (DR-TB) patients and its impact on quality of life (QoL) and adherence to therapy. Findings indicated that ADR could lead to decreased QoL in patients, but did not always result in treatment non-adherence. Comprehensive support from family, community, and healthcare providers is crucial in helping patients cope with the burden of ADR.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Review
Pharmacology & Pharmacy
Ludimila Leite Marzochi, Caroline Izak Cuzziol, Carlos Henrique Viesi Do Nascimento Filho, Juliana Amorim dos Santos, Marcia Maria Urbanin Castanhole-Nunes, Eliete Neves Silva Guerra, Eny Maria Goloni-Bertollo
Summary: Histone modifications play a role in cancer initiation and progression, and targeting these proteins has potential therapeutic value. This review summarizes the development and prospects of histone methyltransferase (HMT) inhibitors in cancer therapy. Several HMT inhibitors have shown significant anti-tumor effects in clinical studies, with tazemetostat being the most advanced in follicular lymphoma treatment. The use of HMT inhibitors has produced promising results in hematological cancers with manageable adverse effects. Ongoing clinical studies suggest a hopeful future for HMT inhibitors in treating different types of cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Engineering, Environmental
Shengqi Zhang, Chengsong Ye, Jianguo Li, Xin Yu, Mingbao Feng
Summary: This study summarized the physicochemical properties, transformation products, and toxicity evolution of five antineoplastic drugs with the highest environmental prevalence. It was found that oxidative treatments were effective in removing these contaminants, but insufficient for complete mineralization, with potential toxicity increasing during the processes.
Article
Health Care Sciences & Services
Leila Abou Salha, Jose Elmo de Menezes, Danilo Rocha Dias, Virginia Visconde Brasil, Pedro Lopes Ferreira, Jolive Mendes de Santana Filho, Maria Alves Barbosa
Summary: This study describes the sociodemographic profile and assesses the health-related quality of life of cancer patients and caregivers in Goias, Brazil, during the COVID-19 pandemic. The findings show the physical and emotional vulnerability of these individuals and highlight the importance of strengthening public policies to support them.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Pharmacology & Pharmacy
Kala Bahadur Rawal, Uday Venkat Mateti, Vijith Shetty, Chakrakodi Shashidhara Shastry, Mazhuvancherry Kesavan Unnikrishnan, Shraddha Shetty, Aparna Rajesh
Summary: This study aims to develop evidence-based indicators for detecting potential drug-related problems in ovarian cancer patients. The feasibility test identified 130 out of 200 indicators and classified the DRPs into four main categories: drug selection problem, drug use problem, adverse drug reaction, and drug-drug interaction. The indicators effectively identified pDRPs and can potentially help healthcare professionals in the early detection and management of DRPs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
John S. Barbieri, Zelma C. Chiesa Fuxench, Daniel B. Shin, Junko Takeshita
Summary: NRRs on the DLQI are common among adults with atopic dermatitis, but there is no clear association with other measures of disease severity.
QUALITY OF LIFE RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Haitao Wang, Haitao Shi, Yan Wang, Na Wang, Youjia Li, Qianting Yang, Ya Li, Chenwei Liu, Ying Zan, Siping Feng, Jiao Xie
Summary: The prevalence of hazardous drug-drug interactions (DDIs) related to oral antineoplastic agents (OAAs) appears to be low in cancer patients. However, physicians and clinical pharmacologists should be aware of the potential hazardous DDIs when prescribing OAAs, especially certain pH-dependent molecular targeted agents and drugs that can prolong QTc interval.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yan-Li Yang, Zi-Jian Xiang, Jing-Hua Yang, Wen-Jie Wang, Zhi-Chun Xu, Ruo-Lan Xiang
Summary: Echinocandins are found to be the most tolerated antifungal agents with high safety through network meta-analysis, while triazole drugs mainly show adverse effects such as elevated liver enzymes and nervous system disorders. LAmB is the least tolerated antifungal agent with the most abundant adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Sungjun Choi, Soo Ick Cho, Cheol Lee, Yoonjin Kwak, Je-Ho Mun
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2020)
Article
Dermatology
Jong H. Won, Keunyoung Hur, Jungyoon Ohn, Je-Ho Mun
DERMATOLOGIC THERAPY
(2020)
Letter
Dermatology
Jungyoon Ohn, Da-Ae Yu, Hyun-sun Park, Soyun Cho, Je-Ho Mun
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2020)
Article
Dermatology
Sang Woong Youn, Dae Young Yu, Tae Yoon Kim, Byung Soo Kim, Seung Chul Lee, Jeung Hoon Lee, Yong-Beom Choe, Joo-Heung Lee, Jee-Ho Choi, Joo Young Roh, Seong Jin Jo, Eun-So Lee, Min Kyung Shin, Min-Geol Lee, Jingzhi Jiang, YoungJa Lee
Summary: The study found that guselkumab demonstrated efficacy and safety in treating moderate-to-severe psoriasis in Korean patients, with better results than adalimumab.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
S. I. Cho, Y. E. Kim, S. J. Jo
Summary: The study found no significant increase in specific skin diseases or exposure to biologics among COVID-19 positive individuals, and the presence of skin diseases and exposure to biologics did not seem to affect clinical outcomes including mortality. Therefore, underlying skin diseases did not appear to increase susceptibility to COVID-19 or mortality from COVID-19.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Jinwoo Lee, Seong Jin Jo, Youngjin Cho, Ji Hyun Lee, Il-Young Oh, Jin Joo Park, Young-Seok Cho, Dong-Ju Choi
Summary: The study found that the use of renin-angiotensin system (RAS) blockers may increase the risk of SARS-CoV-2 infection, but is not associated with higher mortality or other severe clinical courses.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Boram Kim, Man Jin Kim, Keunyoung Hur, Seong Jin Jo, Jung Min Ko, Sung Sup Park, Moon-Woo Seong, Je-Ho Mun
Summary: Nevoid basal cell carcinoma syndrome (NBCCS) in Korean patients is mainly caused by pathogenic variants in the PTCH1 gene. The number of BCCs increases with age, highlighting the importance of regular dermatologic examinations. Genetic screening should be considered as part of the diagnostic criteria for NBCCS.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Sang Woong Youn, Dae Young Yu, Byung Soo Kim, Youngdoe Kim, Kwang Joong Kim, Jee-Ho Choi, Sang Wook Son, Eun-So Lee, Young Suck Ro, Young Lip Park, YoungJa Lee, Jeung Hoon Lee, Hyun Jeong Park, Tae Yoon Kim, Min-Geol Lee, Min Kyung Shin, Gwang Seong Choi, Dong Hyun Kim, Seong Jin Jo, Seung Chul Lee
Summary: Postmarketing surveillance is necessary to establish the safety and effectiveness of drugs in real-world practice. This study aimed to validate the use of ustekinumab in treating adult Korean patients with plaque psoriasis, showing high effectiveness and safety with a low incidence of adverse events. The drug exhibited a high survival rate and predictors for treatment response were identified, emphasizing its value in real-world settings.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Yayoi Tada, Seong Jin Jo, Yu-Huei Huang, Bryan Wahking, Bong Young Lee, Regina Gowindah, Pablo Fernandez-Penas
Summary: Research shows that psoriasis patients seek treatment with the least risk of flare-ups so that they can enjoy clear skin for an extended period of time.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hyokyung Yoo, Hyeonwoo Kim, Sung Tack Kwon, Seong Jin Jo, Je-Ho Mun, Cheol Lee, Yoonjin Kwak, Byung Jun Kim
Summary: This study found that dermal invasion in subungual melanoma mostly occurred in distal areas, with hyponychial invasion being significantly associated with invasion depth, metastatic progression, and disease-free survival.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Ji Won Lee, Kwang Hyun Cho, Chong Won Choi, Seong Jin Jo
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Letter
Dermatology
Y. E. Kim, Y. Cho, S. J. Jo
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Microbiology
Sophie Soyeon Lim, Bo Ri Kim, Je-Ho Mun
Summary: Reflectance confocal microscopy (RCM) is valuable for the diagnosis of onychomycosis, rapidly identifying fungal lesions. Existing studies support the use of RCM in bedside diagnosis of onychomycosis and call for larger studies to further explore its diagnostic utility.
Review
Dermatology
Soo Ick Cho, Ye Eun Kim, Seong Jin Jo
Summary: The meta-analysis of 16 studies showed that pediatric patients with psoriasis have a significantly higher prevalence of obesity, hypertension, diabetes, dyslipidemia, and metabolic syndrome. It is important to consider adequate monitoring and timely management of metabolic comorbidities in these patients.
ANNALS OF DERMATOLOGY
(2021)
Article
Dermatology
Jong Seo Park, Jungyoon Moon, Soo Ick Cho, Je-Ho Mun
ANNALS OF DERMATOLOGY
(2020)
