Article
Multidisciplinary Sciences
Tse Yang Lim, Erin J. Stringfellow, Celia A. Stafford, Catherine DiGennaro, Jack B. Homer, Wayne Wakeland, Sara L. Eggers, Reza Kazemi, Lukas Glos, Emily G. Ewing, Calvin B. Bannister, Keith Humphreys, Douglas C. Throckmorton, Mohammad S. Jalali
Summary: The opioid crisis in the United States is a significant public health challenge, and addressing its complexity requires a quantitative systems model. The SOURCE model tracks the stages of opioid use, addiction treatment, and overdose death, providing insights into the historical trajectory of the crisis and informing policy planning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Public, Environmental & Occupational Health
Sarah E. Gollust, Jake Haselswerdt
Summary: The opioid epidemic has had a profound impact on American public health and politics, with research linking community opioid crisis severity to political behavior. However, individual perceptions are influenced by factors such as actual data, racial perceptions, and geographical location. Despite this, these perceptions did not significantly impact voter behavior in the 2018 midterm election.
SOCIAL SCIENCE & MEDICINE
(2021)
Editorial Material
Oncology
Emily C. Serrell, Caprice C. Greenberg, Tudor Borza
Summary: Opioid prescribing after surgery remains a significant contributor to the national opioid epidemic, highlighting the need for direct engagement with surgeons and detailed data to address the limited response to current policies.
Review
Biochemistry & Molecular Biology
Rita Tabanelli, Simone Brogi, Vincenzo Calderone
Summary: This review article discusses the potential use of opioids in treating various diseases and focuses on targeting opioid receptors for treating opioid use disorder, drug withdrawal, and addiction. However, the use of opioids is associated with numerous side effects. Therefore, the identification of opioid receptor ligands with fewer adverse effects is necessary. The article analyzes promising molecules for the treatment of opioid use disorder, including in vivo studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Alex S. Bennett, Honoria Guarino, Peter C. Britton, Dan O'Brien-Mazza, Stephanie H. Cook, Franklin Taveras, Juan Cortez, Luther Elliott
Summary: U.S. military veterans have been significantly affected by the opioid overdose crisis, with a 53% increase in drug overdose mortality rates from 2010 to 2019. The risk of overdose among veterans is influenced by various factors, including physiological, psychological, and social factors. Addressing the overdose crisis in this population requires comprehensive interventions that consider pain, pain treatment, stress, and psychological and social experiences before, during, and after military service.
ANNALS OF MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Chibuzor Abasilim, Alfreda Holloway-Beth, Lee S. S. Friedman
Summary: This study linked hospital and medical examiner data to determine potential undercount of opioid-involved deaths occurring in hospitals. The results showed that older patients with longer hospital stays and comorbid malignant cancer were less likely to have an autopsy following an opioid-involved death. However, decedents exposed to heroin and synthetic opioids, as well as those with concurrent exposure to stimulants, were more likely to have an autopsy. The study revealed undercounts of opioid overdose deaths ranging from 6% to 15%.
Article
Psychiatry
Mimi Pierce, Jan van Amsterdam, Gerard A. Kalkman, Arnt Schellekens, Wim van den Brink
Summary: The study investigated the opioid situation in 19 European countries, comparing trends in prescription opioid use and related adversities between 2010 and 2018 with data from the US. While most European countries showed increased prescription opioid consumption, the highest rates of high-risk opioid users, opioid-related hospital admissions, deaths, treatment admissions, and patients in opioid substitution therapy were in Scotland, with rates similar to or higher than those in the US. The study suggests that, apart from the British Isles and particularly Scotland, there is no indication of an opioid crisis comparable to that in the US in the European countries studied, calling for more research and interventions in the UK and Ireland.
EUROPEAN PSYCHIATRY
(2021)
Article
Substance Abuse
Johannes Thrul, Jill A. Rabinowitz, Beth A. Reboussin, Brion S. Maher, Nicholas S. Ialongo
Summary: This study investigated the associations between adolescent cannabis, tobacco, and alcohol use and opioid use in young adulthood. The results showed that more frequent cannabis or tobacco use at age 14 was associated with more frequent opioid use at age 19. Cannabis and tobacco use in early adolescence may be risk factors for opioid use in young adulthood among African Americans living in urban areas.
Article
Environmental Sciences
Atsuhiko Isobe, Shinsuke Iwasaki
Summary: This study estimates the mass of ocean plastics by combining numerical particle tracking and linear mass-balance models. The results show that ocean plastics account for only a small percentage of mismanaged plastic waste generated over the years.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Critical Care Medicine
Erin K. Stenson, Gina DeMasellis, Ananya Shah, Pamela D. Reiter, John Brinton, Sara Martin, Melissa Iwanowski, Michael Rannie, Danielle E. Soranno, Katja M. Gist
Summary: Implementing a quality improvement program in critically ill children effectively decreased the rates of nephrotoxic medication exposure without inadvertently increasing opioid and benzodiazepine exposure.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Orthopedics
Krista B. B. Highland, Hillary A. A. Sowa, Germaine F. F. Herrera, Austin G. G. Bell, Kyle L. L. Cyr, Alexander G. G. Velosky, Jeanne C. C. Patzkowski, Trevor Kanter, Michael S. S. Patzkowski
Summary: This study analyzed electronic health data of patients undergoing total knee and hip arthroplasty in the Military Health System. It found multiple factors associated with prescribing practices and outcomes after surgery. Future research is needed to identify optimal approaches to reduce unwarranted and inequitable healthcare variation within a patient-centered framework.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Medical Laboratory Technology
Jan van Amsterdam, Mimi Pierce, Wim van den Brink
Summary: The United States is facing an opioid overdose crisis due to over-prescription and aggressive marketing, while in Europe, although prescription opioid use has increased, there is no evidence of a similar crisis except in Scotland. Authorities should be vigilant despite declining prescription rates in Europe.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Neurosciences
Regis Trapeau, Etienne Thoret, Pascal Belin
Summary: Although the Temporal Voice Areas (TVAs) show a stronger response to speech sounds than non-speech vocal sounds, this does not necessarily mean that they are Temporal Speech Areas. By analyzing fMRI activations of a balanced set of speech and non-speech vocal sounds using univariate, multivariate, and representational similarity analyses, we find that speech sounds activate the TVAs more due to their larger temporal modulations in syllabic rate, but they do not activate additional areas nor are they segregated from non-speech vocal sounds when their higher activation is controlled. It appears reasonable to continue referring to these regions as the Temporal Voice Areas.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Medical Laboratory Technology
Paul J. Jannetto
Summary: This article summarizes the background, current situation, and response measures of the opioid crisis in North America, emphasizing the abuse of opioids in the United States and Canada and the resulting deaths and health issues.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Pharmacology & Pharmacy
Adrian Szczepaniak, Weronika Machelak, Jakub Fichna, Marta Zielinska
Summary: Opioids are widely used as effective analgesics for cancer pain and postoperative pain in most countries. This review focuses on the involvement of KOP receptors in the inflammatory process, describing their function in various conditions where the immune system plays a key role.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Rheumatology
Charlotte L. M. Krieckaert, Astrid van Tubergen, Johanna Elin Gehin, Borja Hernandez-Breijo, Guillaume Le Meledo, Alejandro Balsa, Peter Boehm, Sasa Cucnik, Ori Elkayam, Guro L. Goll, Femke Hooijberg, Meghna Jani, Patrick D. W. Kiely, Neil McCarthy, Denis Mulleman, Victoria Navarro-Compan, Katherine Payne, Martin E. Perry, Chamaida Plasencia-Rodriguez, Simon R. Stones, Silje Watterdal Syversen, Annick de Vries, Katherine M. Ward, Gertjan Wolbink, John D. Isaacs
Summary: This study develops EULAR points-to-consider for therapeutic drug monitoring (TDM) of biopharmaceuticals in inflammatory rheumatic and musculoskeletal diseases (RMDs). The points-to-consider are evidence-based and consensus-based statements that highlight the clinical utility of TDM. However, the lack of high quality trials addressing effectiveness and safety of TDM, as well as robust economic evaluation, limits its wider adoption.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Anastasia-Vasiliki Madenidou, Graham Dinsdale, Muditha Samaranayaka, Lindsay Muir, William G. Dixon, Ariane L. Herrick
Article
Rheumatology
Ryan M. Hum, Pauline Ho, Nisha Nair, Meghna Jani, Ann W. Morgan, John D. Isaacs, Anthony G. Wilson, Kimme L. Hyrich, Darren Plant, Anne Barton
Summary: This study suggests that higher levels of TNF-a inhibitor serum drug levels (SDLs) are associated with good treatment response in fully adherent patients. Interventions to improve SDLs, such as encouraging adherence, may improve treatment response. The identified SDL cut-offs for adalimumab and certolizumab may be useful in clinical practice.
Article
Public, Environmental & Occupational Health
Meghna Jani, Belay Birlie Yimer, David Selby, Mark Lunt, Goran Nenadic, William G. Dixon
Summary: This study aimed to examine the impact of incorporating narrative prescribing instructions and subsequent drug preparation assumptions on adverse event rates, using a worked example of opioids and fracture risk. The results showed that assumptions made during the drug preparation process, especially for those with variability in prescription instructions, can impact subsequent risk estimates.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Letter
Rheumatology
Yun-Ting Huang, David A. Jenkins, Niels Peek, William G. Dixon, Meghna Jani
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Health Care Sciences & Services
Quynh Pham, David Wong, Kaylen J. Pfisterer, Dionne Aleman, Nick Bansback, Joseph A. Cafazzo, Alexander J. Casson, Brian Chan, William Dixon, Gerasimos Kakaroumpas, Claudia Lindner, Niels Peek, Henry W. W. Potts, Barbara Ribeiro, Emily Seto, Charlotte Stockton-Powdrell, Alexander Thompson, Sabine van der Veer
Summary: The international deployment of remote monitoring and virtual care technologies can have a positive impact on outcomes. However, transferring these innovations between countries can be complicated by several key differences. Recommendations include considering country-specific factors, mapping available pathways, sharing regulatory learnings, and exploring existing guidance. These recommendations contribute to successful international deployment and increased positive impact.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Health Care Sciences & Services
William G. Dixon, Sabine N. van der Veer, Syed Mustafa Ali, Lynn Laidlaw, Richard J. B. Dobson, Cathie Sudlow, Tim Chico, Jacqueline A. L. MacArthur, Aiden Doherty
Summary: The use of data from smartphones and wearable devices has great potential for population health research, but the uptake of large-scale mobile health research has not met expectations. Digital person-generated health data are crucial for answering research questions, but there are challenges such as data inequality, selection bias, data collection tools, data harmonization, time series data analysis, and patient and public involvement. Establishing an interdisciplinary community can transform people's lives for the better.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Letter
Rheumatology
Philippa D. K. Curry, Hector Chinoy, Meghna Jani, Darren Plant, Kimmie L. Hyrich, Ann W. Morgan, A. G. Wilson, John D. Isaacs, Andrew P. Morris, Anne Barton, James Bluett
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Syed Mustafa Ali, Rebecca R. Lee, John McBeth, Ben James, Sean McAlister, Alessandro Chiarotto, William G. Dixon, Sabine N. van der Veer
Summary: This study aimed to inform the development of cross-culturally acceptable digital pain self-report tools by understanding the similarities and differences between ethnic groups in pain experiences and self-reporting needs. The findings showed that participants from different ethnic groups faced similar challenges in communicating their pain to healthcare professionals, but had differences in beliefs about pain causes, attitudes toward pain medication, and experiences of stigma and gender norms influencing pain-reporting behavior. Future research and development should address these differences in pain perceptions and beliefs, factors influencing pain reporting behavior, and language requirements to improve cross-cultural acceptability and equity of digital pain self-report tools.
JMIR HUMAN FACTORS
(2023)
Article
Rheumatology
Yun-Ting Huang, David A. Jenkins, Belay Birlie Yimer, Jose Benitez-Aurioles, Niels Peek, Mark Lunt, William G. Dixon, Meghna Jani
Summary: This study investigated opioid prescribing trends and the impact of the COVID-19 pandemic on opioid prescribing in patients with rheumatic and musculoskeletal diseases (RMDs). The results showed that the number of new opioid users for RA, PsA, and FM increased and then decreased after 2018. The number of prevalent opioid users for all RMDs increased but plateaued or dropped after 2018. During the COVID-19 pandemic, there were significant changes in the trend of prevalent opioid users for RA, PsA, and FM.
Editorial Material
Medicine, General & Internal
Alessia Alunno, Chris Wincup, Meghna Jani, Dario Roccatello, Javier Rodriguez-Carrio
FRONTIERS IN MEDICINE
(2023)
Article
Rheumatology
Adrian K. Davison, Graham Dinsdale, Paul New, Joanne Manning, Helen Patrick, Vicky P. Taxiarchi, William G. Dixon, Andy Vail, Andrea K. Murray, Mark Dickinson, Christopher Taylor, Ariane L. Herrick
Summary: Taking smartphone photographs of digital ulcers was feasible for most patients, with good image quality, and has the potential to be an outcome measure for systemic sclerosis treatment.
RHEUMATOLOGY ADVANCES IN PRACTICE
(2022)
