Review
Biology
Saad Emhmed Ali, Mindie H. Nguyen
Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is continuously increasing, closely associated with metabolic disorders such as obesity and insulin resistance. Sarcopenia and sarcopenic obesity have a negative impact on outcomes for individuals with NAFLD, and are expected to rise as obesity rates increase. Further research is needed to better define and manage these conditions.
Review
Endocrinology & Metabolism
Serena Scapaticci, Ebe D'Adamo, Angelika Mohn, Francesco Chiarelli, Cosimo Giannini
Summary: NAFLD is the most prevalent form of chronic liver disease in children and adolescents worldwide, with a significant increase in affected young people in recent decades, mainly due to childhood obesity. Insulin resistance and abnormal glucose tolerance are key features of NAFLD, which is also closely associated with Metabolic Syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yi Chen, Xueyang Chen, Qiang Chen, Chaohui Yu
Summary: The prevalence of NAFLD is higher in PA patients compared to non-PA patients, with hypokalemic PA patients having a worse metabolic status. Although NAFLD is more common in PA patients, the patterns of obesity, dyslipidemia, and insulin resistance are similar. This study provides new insights for further investigations into metabolic imbalance in patients with aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaoyun Cheng, Zhibing Fu, Wei Xie, Liyong Zhu, Jie Meng
Summary: This study investigates the role of serum Prdx1 in NAFLD patients with obesity undergoing LSG and develops a prognostic model for predicting the remission of severe NAFLD. The results show that baseline Prdx1, TyG, and HSI levels are independently associated with NAFLD remission at three months after LSG. The developed nomogram model has a high predictive ability in both the primary and validation cohorts.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Seol Hwa Seo, Eunhwan Kim, Minguen Yoon, Soung-Hoon Lee, Byung-Hyun Park, Kang-Yell Choi
Summary: This study found that the small molecule KY19334 can effectively treat obesity-related liver disease NASH by activating the Wnt/β-catenin signaling pathway. The treatment suppressed inflammation, steatosis, oxidative stress, and cell death, reversed liver fibrosis, and enhanced liver regeneration.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Nuria Perez-Diaz-Del-Campo, Jose I. Riezu-Boj, Bertha A. Marin-Alejandre, J. Ignacio Monreal, Mariana Elorz, Jose I. Herrero, Alberto Benito-Boillos, Fermin I. Milagro, Elisabetta Bugianesi, Josep A. Tur, J. Alfredo Martinez, Itziar Abete, M. Angeles Zulet
Summary: This study successfully established a model based on genetic and hepatic health information to personalize dietary treatment for overweight/obese NAFLD patients according to their genetic and insulin resistance markers. The results showed that this model could effectively predict changes in hepatic health indicators, providing new insights into NAFLD weight loss treatments.
Article
Plant Sciences
Qiao-Ping Li, Yao-Xing Dou, Zi-Wei Huang, Han-Bin Chen, Yu-Cui Li, Jian-Nan Chen, Yu-Hong Liu, Xiao-Qi Huang, Hui-Fang Zeng, Xiao-Bo Yang, Zi-Ren Su, Jian-Hui Xie
Summary: The study found that OBB showed more significant effects in treating NAFLD compared to BBR, maintaining lipid homeostasis between liver and white adipose tissue by attenuating hepatic insulin pathway and adipocyte inflammation, which is associated with its superior AMPK activation.
Article
Chemistry, Multidisciplinary
Mayuko Chikamatsu, Hiroshi Watanabe, Yuhi Shintani, Ryota Murata, Masako Miyahisa, Ayano Nishinoiri, Tadashi Imafuku, Mei Takano, Nanaka Arimura, Kohichi Yamada, Miya Kamimura, Baki Mukai, Takao Satoh, Hitoshi Maeda, Toru Maruyama
Summary: Non-alcoholic fatty liver disease (NAFLD) affects 25% of the world's population, but there are currently no approved treatments. This study evaluates the therapeutic effect of a protein called HSA-FGF21 on NAFLD induced by high-fat diets. The administration of HSA-FGF21 showed improvements in body weight, glucose levels, and lipid accumulation in the liver. It also suppressed the expression of fatty acid uptake receptors and inflammatory cytokines. HSA-FGF21 has potential as a therapeutic agent for NAFLD.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Endocrinology & Metabolism
Dieter Furthner, Christian-Heinz Anderwald, Peter Bergsten, Anders Forslund, Joel Kullberg, Hakan Ahlstrom, Hannes Manell, Iris Ciba, Harald Mangge, Katharina Maruszczak, Pia Koren, Sebastian Schuetz, Susanne Maria Brunner, Anna Maria Schneider, Daniel Weghuber, Katharina Moerwald
Summary: SPISE is a novel and cost-effective index of hepatic insulin resistance, showing superior diagnostic ability in children and adolescents with obesity. It is significantly lower in patients with NAFLD, indicating sensitivity and specificity for hepatic IR better than established indices.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Marta Carrillo-Palau, Alejandro Hernandez-Camba, Noemi Hernandez Alvarez-Buylla, Laura Ramos, Inmaculada Alonso-Abreu, Anjara Hernandez-Perez, Milagros Vela, Laura Arranz, Manuel Hernandez-Guerra, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study found that insulin resistance (IR) is not increased in inflammatory bowel disease (IBD) patients with low disease activity compared to controls. However, the presence of nonalcoholic fatty liver disease (NAFLD) favors the development of IR in patients with IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Sadaf Dabeer, Sheikh Raisuddin
Summary: This study examined the intergenerational effect of parental exposure to an environmentally relevant dose of BPA on the hepatic health outcome of their offspring in a metabolically challenged population. The results showed that BPA exposure led to increased birth weight and rapid weight gain in the offspring, along with changes in liver function enzymes, histological changes in the liver tissue, and the onset of non-alcoholic fatty liver disease (NAFLD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Kyongmin Park, Hye Sun Lee, Hoon-Ki Park, Jee Hye Han, Sang Bong Ahn
Summary: This study found that metabolic score for IR (METS-IR) was inversely associated with ALF in patients with NAFLD, and its predictive ability for ALF was higher than that of triglyceride-glucose (TyG) index and homeostatic model assessment for IR (HOMA-IR).
Article
Nutrition & Dietetics
Sujinda Songtrai, Wasana Pratchayasakul, Busarin Arunsak, Titikorn Chunchai, Aphisek Kongkaew, Nipon Chattipakorn, Siriporn C. Chattipakorn, Sireewan Kaewsuwan
Summary: This study found that extract enriched by interruptins A and B (EEI) can improve insulin resistance and non-alcoholic fatty liver disease (NAFLD) induced by a high-fat diet. The therapeutic effects of EEI are achieved through the improvement of insulin signaling pathways, inflammatory response, lipogenesis, and fatty acid oxidation.
Article
Biochemistry & Molecular Biology
Carolina Panzarin, Lais Angelica de Paula Simino, Mariana Camargo Silva Mancini, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: The modulation of hepatic miR-370-122-Let7 miRNA may play a crucial role in the early stages of NAFLD, preceding changes in glycemic homeostasis and adiposity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Medicine, General & Internal
Aikaterini Giannouli, Vasiliki Efthymiou, Marianna Konidari, Iliana Mani, Leon Aravantinos, Spyridon P. Dourakis, Aristeidis Antoniou, Efthymios Deligeoroglou, Flora Bacopoulou
Summary: The aim of this case-control study was to assess the burden of non-alcoholic fatty liver disease (NAFLD) in adolescents with polycystic ovary syndrome (PCOS) and its associations with insulin resistance, hyperandrogenism, and other metabolic characteristics of the syndrome. The study found that NAFLD was more prevalent in adolescents with PCOS compared to controls, and it was associated with insulin resistance and liver fat indices. Adolescents with PCOS and higher levels of free androgen index (FAI) had worse NAFLD and insulin sensitivity indices than those with lower FAI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hyun-Jin Kim, Yang-Hyun Kim, Kyung-Hwan Cho, Byoung-Duck Han, Seon-Mee Kim, Youn-Seon Choi, Do-Hoon Kim, Kyung-Do Han, Yong-Joo Lee, Chul-Min Kim
JOURNAL OF BONE AND MINERAL METABOLISM
(2016)
Article
Psychiatry
Taeryoon Kim, Ga Eun Nam, Byoungduck Han, Sung Jung Cho, Junghun Kim, Do Hyun Eum, Sang Woo Lee, Soon Hong Min, Woohyun Lee, Kyungdo Han, Yong Gyu Park
ARCHIVES OF WOMENS MENTAL HEALTH
(2018)
Article
Endocrinology & Metabolism
Ga Eun Nam, Kyung Hwan Cho, Kyungdo Han, Byoungduck Han, Sung Jung Cho, Yong Kyun Roh, Seon Mee Kim, Youn Seon Choi, Do Hoon Kim, Yang Hyun Kim, Yong Gyu Park
INTERNATIONAL JOURNAL OF OBESITY
(2019)
Article
Endocrinology & Metabolism
Kyung Shik Lee, Ji Su Jang, Dong Ryul Lee, Yang Hyun Kim, Ga Eun Nam, Byoung-duck Han, Kyung Do Han, Kyung Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do Hoon Kim
JOURNAL OF BONE AND MINERAL METABOLISM
(2014)
Article
Urology & Nephrology
Ga Eun Nam, Kyungdo Han, Yong Gyu Park, Yang Hyun Kim, Byoungduck Han, Seon Mee Kim, Youn Seon Choi, Kyung Hwan Cho, Kyung Shik Lee, Do Hoon Kim
NEPHRON CLINICAL PRACTICE
(2013)
Article
Multidisciplinary Sciences
Hye Won Kim, Yang-Hyun Kim, Kyungdo Han, Ga Eun Nam, Gwang Seon Kim, Byoung-Duck Han, Anna Lee, Ji Yong Ahn, Byung Joon Ko
Article
Multidisciplinary Sciences
Kyu-Chong Lee, Kyungdo Han, Jin Yong Kim, Ga Eun Nam, Byoung-Duck Han, Koh-Eun Shin, Anna Lee, Byung Joon Ko
Article
Public, Environmental & Occupational Health
Ga Eun Nam, Kyung Hwan Cho, Yong Gyu Park, Kyung Do Han, Youn Seon Choi, Seon Mee Kim, Kyung Shik Lee, Byung Joon Ko, Yang Hyun Kim, Byoung Duck Han, Do Hoon Kim
PREVENTIVE MEDICINE
(2013)
Article
Medicine, General & Internal
Ga Eun Nam, Byoungduck Han, Chae Lin Joo, Seo Young Kang, Jisun Lim, Yang-Hyun Kim, Hye Soon Park
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Byoungduck Han, Gyu Bae Lee, Sun Young Yim, Kyung-Hwan Cho, Koh Eun Shin, Jung-Hwan Kim, Yong-Gyu Park, Kyung-Do Han, Yang-Hyun Kim
Summary: The study investigated the impact of fatty liver index (FLI) on the incidence of heart failure (HF) using large cohort data from the Korean National Health Insurance health database. The results showed that FLI >= 60 was associated with higher HF incidence, and an increase in FLI score significantly increased the risk of HF.
Article
Endocrinology & Metabolism
Eun-Yong Choi, Chan Young Park, Seong Hyun Ho, Su-Jin Park, Donghyun Kim, Byoungduck Han, Seon-Hee Kim
Summary: The study suggests that water extracts of Artemisia annua (WEAA) can reduce adipocyte differentiation and fat accumulation, inhibiting obesity and fatty liver caused by a high-fat diet. WEAA can affect fat metabolism, regulate differentiation between brown and white adipose tissues, and potentially play a role in the treatment of obesity.
JOURNAL OF OBESITY & METABOLIC SYNDROME
(2021)
Article
Primary Health Care
Sang-Woo Lee, Byoungduck Han, Sung Jung Cho, Seung Jin Jung, Youn Huh, Junghun Kim, Hyun Eum, Taeryoon Kim, Soon-Hong Min, Woohyun Lee, Jinhee Cho, Min Hee Kwon, Ga Eun Nam
KOREAN JOURNAL OF FAMILY MEDICINE
(2020)
Article
Primary Health Care
Min-Kyung Kim, Byung Joon Ko, E-Yeon Kim, Byoung-Duck Han, Kyung-Hwan Cho
KOREAN JOURNAL OF FAMILY MEDICINE
(2015)
Article
Endocrinology & Metabolism
Yirang Kim, Byoung-Duck Han, Kyungdo Han, Koh Eun Shin, Halla Lee, Tae Ri Kim, Kyung Hwan Cho, Do Hoon Kim, Yang Hyun Kim, Hyunjin Kim, Ga Eun Nam