Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Zhilan Xie, Ruxianguli Aimuzi, Mingyu Si, Yimin Qu, Yu Jiang
Summary: This study aims to investigate the associations of 13 urinary metals, individually and jointly, with NAFLD, MAFLD, and MAFLD components. The findings suggest that exposure to heavy metals, both individually and cumulatively, is positively associated with NAFLD, MAFLD, and its components, including obesity/overweight, diabetes, and metabolic dysfunction.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Jianli Zhou, Xiaojing Meng, Lugang Deng, Nan Liu
Summary: This study examines the associations between blood levels of typical heavy metals and metabolic syndrome (MetS) among adults. The findings suggest that higher levels of blood lead, cadmium, and mercury are associated with a lower risk of MetS, while higher levels of blood manganese are associated with a higher risk of MetS in the age group of 30-49 years. Non-linear associations between heavy metal levels and MetS risk were also observed.
Article
Medicine, General & Internal
Jeong-Ju Yoo, Eun Ju Cho, Goh Eun Chung, Young Chang, Yuri Cho, Sang-Hyun Park, Su-Min Jeong, Bo-Yeon Kim, Dong Wook Shin, Yun Joon Kim, Jung-Hwan Yoon, Kyungdo Han, Su Jong Yu
Summary: This study investigated whether nonalcoholic fatty liver disease (NAFLD) could be a precursor for metabolic syndrome (MetS) in young adults. The results showed that both the NAFLD group and the borderline NAFLD group had a higher risk of developing MetS compared to the control group. Additionally, all metabolic components were positively associated with the fatty liver index (FLI).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hai Nguyen Duc, Hojin Oh, Min-Sun Kim
Summary: The study found that low intake of vitamins and high serum levels of heavy metals are associated with an increased risk of MetS, while high curry consumption is associated with a reduced risk of MetS. Increased intake of vitamin B1 and C can lower the risk of MetS, whereas an increase in serum levels of Pb, Hg, and hs-CRP can increase the risk of MetS.
Review
Gastroenterology & Hepatology
Seong Hee Kang, Yuri Cho, Soung Won Jeong, Seung Up Kim, Jin-Woo Lee
Summary: The transition from NAFLD to MAFLD involves including FLD subjects with metabolic abnormalities in the criteria while excluding those without, leading to a focus on metabolic dysfunction in the MAFLD criteria. This may underestimate the prognostic value of hepatic steatosis, but could better identify subjects at higher risk of liver or cardiovascular outcomes.
CLINICAL AND MOLECULAR HEPATOLOGY
(2021)
Review
Environmental Sciences
Alexey A. Tinkov, Michael Aschner, Abel Santamaria, Alfred R. Bogdanov, Yousef Tizabi, Miriam B. Virgolini, Ji-Chang Zhou, Anatoly V. Skalny
Summary: The objective of this study was to review existing epidemiological and laboratory findings supporting the role of toxic metal exposure in non-alcoholic fatty liver disease (NAFLD). The existing studies demonstrate a link between exposure to cadmium, lead, arsenic, and mercury and an increased risk of NAFLD, as well as altered liver injury markers. Laboratory studies also show that metal exposure leads to hepatic lipid accumulation and affects metabolic pathways and inflammatory response.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Abbas Ali Sangouni, Mohammad Alizadeh, Atena Jamalzehi, Karim Parastouei
Summary: Garlic supplementation significantly improves MetS components, insulin resistance, FLI, and appetite.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Nour Ayoub, Hiba Mantash, Hassan R. Dhaini, Abbas Mourad, Mohammad Hneino, Zeina Daher
Summary: The study found a significant association between serum cadmium levels and dyslipidemia risk, but not with diabetes and obesity outcomes. Elevated cadmium levels increase the risk of dyslipidemia and alter blood lipid profiles, but do not support a role for cadmium in diabesity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Endocrinology & Metabolism
Chia-Chu Liu, Shu-Pin Huang, Yung-Chin Lee, Cheng-Hsueh Lee, Tsung-Yi Huang, Jiun-Hung Geng, Che-Wei Chang, Chung-Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Tusty-Jiuan Hsieh
Summary: The study found an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and testosterone deficiency (TD) in aging Taiwanese men, particularly in those without metabolic syndrome (MetS). This suggests that MAFLD could serve as an early predictor of TD, facilitating the identification of high-risk individuals and enabling timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Gianni Testino, Rinaldo Pellicano
Summary: Patients with liver disease often have multiple contributing factors, such as metabolic syndrome and alcohol consumption. The impact of alcohol consumption is often underestimated and not adequately studied. Understanding the combined effects of these factors is crucial in assessing liver injury.
Review
Endocrinology & Metabolism
Jingting Lyu, Qinghong Lin, Zhongbiao Fang, Zeling Xu, Zhengtao Liu
Summary: The study found associations between gallstone disease and metabolic syndrome, as well as nonalcoholic fatty liver disease. Risk of developing nonalcoholic fatty liver disease was also increased after cholecystectomy. Prevention strategies should be considered.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Karla Mucino-Sandoval, Ana Carolina Ariza, Eduardo Ortiz-Panozo, Maria Luisa Pizano-Zarate, Adriana Mercado-Garcia, Robert Wright, Martha Maria Tellez-Rojo, Alison P. Sanders, Marcela Tamayo-Ortiz
Summary: This study suggests that early life exposure to lead may alter early indicators of metabolic syndrome (MetS), with high lead exposure associated with total cholesterol (TC) and triglycerides (TGs).
FRONTIERS IN PEDIATRICS
(2021)
Article
Environmental Sciences
Kehong Liang, Shiping Bai, Hong Zhu
Summary: This study aimed to investigate the impact of selenium and heavy metals on the quality and nutritional composition of egg yolk and albumen. The results showed that selenium supplementation increased the percentage of egg yolk, while heavy metals had varying effects on the levels of chromium, cadmium, and mercury in the yolks. Positive correlations were observed between selenium and cadmium and lead, while heavy metals had minimal effects on the fatty acid composition of egg yolk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Won Sohn, Heon-Ju Kwon, Yoosoo Chang, Seungho Ryu, Yong Kyun Cho
Summary: This study found that risk factors for liver fibrosis in MAFLD patients include serum ferritin level, Fibrosis-4 index, insulin resistance, metabolic syndrome, etc., and the proportion of liver fibrosis varies among different subgroups.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Environmental Sciences
Fei Wang, Ruilin Zhang, Scott W. Donne, Yaser Beyad, Xiangyue Liu, Xiaoyu Duan, Tongsa Yang, Peiyuan Su, Hongwen Sun
Summary: The addition of minerals can enhance the carbon sequestration potential of biochar by promoting the formation of stable carbon structures and highly aromatic structures. The minerals also increase the chemical and thermal stability of biochar.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Shun-Wen Hsiao, Chuan-San Fan, Hsu-Heng Yen, Siou-Ping Huang, Yang-Yuan Chen, Pei-Yuan Su
Summary: A high prevalence (28.7%) of positive anti-nuclear antibodies (ANA) was found in patients with chronic hepatitis C. The most commonly detected ANA pattern was AC-1 (homogeneous) (25.9%), followed by AC-4 (fine speckled) (25.2%) and AC-21 (anti-mitochondrial antibody) (9.6%). Higher positive ANA was associated with lower viral load, lower alanine aminotransferase level, and higher advanced fibrosis. Additionally, higher positive ANA (more than 1:640) was significantly associated with lower estimated glomerular filtration rate (eGFR).
Article
Immunology
Xunlang Zhang, Xinhui Wu, Huang Huang, Kangming Du, Yingying Nie, Peiyuan Su, Yuefei Li
Summary: This study identified characteristic genes of immunotherapy response in non-small cell lung cancer using machine learning algorithm. Two patient subtypes were identified and one subtype showed higher sensitivity to immunotherapy. Various biological pathways were found to be activated in this subtype. Female patients were found to be more adaptable to immunotherapy. Monocytes might have a potential role in affecting immunotherapy response. Potential targets affecting immunotherapy and patient survival were also identified.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Chen-Ta Yang, Hsu-Heng Yen, Yang-Yuan Chen, Pei-Yuan Su, Siou-Ping Huang
Summary: This retrospective study aimed to evaluate the pattern of radiation exposure in Taiwanese IBD patients. The results showed higher radiation exposure among CD patients compared to patients with UC, indicating the complicated nature of the disease. Therefore, increasing the use of radiation-free medical imaging such as intestinal ultrasound or magnetic resonance imaging should be advocated to decrease the risk of excessive radiation exposure in these patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Physical
Jianing Yue, Liang Zhou, Peiyuan Su, Lie Tian, Guangliu Ran, Wenkai Zhang
Summary: Transient absorption spectroscopy is a powerful technique for studying ultrafast processes. However, severe light scattering in the sample can lead to poor quality TA spectra. We propose an experimental approach to eliminate all noise caused by pump scattering in TA spectra using phase and amplitude modulation. The method has been demonstrated to effectively remove additive noise and convolution noise in TA caused by pump scattering through theoretical analysis and experiments.
Article
Chemistry, Physical
Peiyuan Su, Jianing Yue, Qingyu Kong, Wenkai Zhang
Summary: In this study, the excited state intramolecular proton transfer process of 1,4-dihydroxyanthraquinone in acetonitrile was investigated using steady-state spectroscopy, transient absorption spectroscopy, and density functional theory calculations. It was found that 1,4-dihydroxyanthraquinone has three different structures in acetonitrile, and the presence of multiple structures in the ground state is responsible for the wide and vibrational absorption spectrum of this molecule. The results suggest that the intramolecular excited state proton transfer process occurs in a single proton transfer structure.
Article
Gastroenterology & Hepatology
Chen-Hua Liu, Cheng-Yuan Peng, Chun-Jen Liu, Chi-Yi Chen, Ching-Chu Lo, Kuo-Chih Tseng, Pei-Yuan Su, Wei-Yu Kao, Ming-Chang Tsai, Hung-Da Tung, Hao-Tsai Cheng, Fu-Jen Lee, Chia-Sheng Huang, Ke-Jhang Huang, Yu-Lueng Shih, Sheng-Shun Yang, Jo-Hsuan Wu, Hsueh-Chou Lai, Yu-Jen Fang, Po-Yueh Chen, Jow-Jyh Hwang, Chi-Wei Tseng, Wei-Wen Su, Chun-Chao Chang, Pei-Lun Lee, Jyh-Jou Chen, Chi-Yang Chang, Tsai-Yuan Hsieh, Chung-Hsin Chang, Yi-Jie Huang, Jia-Horng Kao
Summary: This multicenter study evaluated the efficacy and safety of sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) for retreating East Asian patients with hepatitis C virus (HCV) infection who previously received NS5A direct-acting antivirals (DAAs). The results showed that SOF/VEL/VOX is highly effective and well-tolerated for these patients.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Pei-Yuan Su, Jia-Kang Wang, Shu-Wen Chang
Summary: This study analyzed CT images to investigate the anatomical details of the bony nasolacrimal duct (BNLD) and determine its impact on primary acquired nasolacrimal duct obstruction (PANDO). The results showed that a small minimum transverse diameter of the BNLD may increase the risk of PANDO. However, there was no significant association between nasal abnormalities and PANDO.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Peiyuan Su, Guangliu Ran, Hang Wang, Jianing Yue, Qingyu Kong, Zhishan Bo, Wenkai Zhang
Summary: The research on perylene diimide (PDI) aggregates has effectively promoted their applications in organic photovoltaic solar cells and fluorescent sensors. In this study, a PDI trimer with different absorption and fluorescence properties in the presence of water in the mixed solvent of THF is investigated. The results show that the hydrophobicity of PDI trimer plays a crucial role in its aggregate properties and provides guidance for the design of PDI-based organic photovoltaic solar cells.
Article
Medicine, General & Internal
Chia-Bang Chen, Chun-Min Chen, Ruo-Han Tzeng, Chen-Te Chou, Pei-Yuan Su, You-Chuen Hsu, Cheng-Da Yang
Summary: This study retrospectively evaluated the efficacy of combined sorafenib and hepatic arterial infusion chemotherapy (HAIC) treatment for advanced HCC, comparing it with sorafenib alone. The combination therapy showed improved image response and objective response rate. Among patients under 65 years old and male patients, the combination therapy also had a better progression-free survival than sorafenib alone. However, there was no significant difference in overall survival between the two groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pei-Yuan Su, Yang-Yuan Chen, Chun-Yu Lin, Wei-Wen Su, Siou-Ping Huang, Hsu-Heng Yen
Summary: The reported prevalence of non-alcoholic fatty liver disease in studies of lean individuals ranges from 7.6% to 19.3%. The aim of the study was to develop machine-learning models for the prediction of fatty liver disease in lean individuals. A two-class neural network using 10 features had the highest AUROC value (0.885) among all other algorithms, indicating its greater predictive value for fatty liver in lean individuals compared to the fatty liver index (FLI).
Article
Biochemistry & Molecular Biology
Chih-Wen Huang, Chen-Ta Yang, Pei-Yuan Su, Yang-Yuan Chen, Siou-Ping Huang, Hsu-Heng Yen
Summary: This study compared the relapse rates of chronic hepatitis B patients after discontinuation of nucleos(t)ide analogues therapy with tenofovir alafenamide (TAF) and entecavir. The results showed that at 12 weeks after discontinuation, no patients in the entecavir group had relapsed, while three patients (7.9% cumulative rate) in the TAF group had relapsed. At 24 and 48 weeks, the cumulative rates of relapse in the entecavir and TAF groups were significantly different. Therefore, close monitoring of liver function and HBV DNA levels is necessary, especially within 24 weeks after discontinuation of TAF therapy.
Article
Medicine, General & Internal
Shun-Wen Hsiao, Ting-Chun Chen, Pei-Yuan Su, Chen-Ta Yang, Siou-Ping Huang, Yang-Yuan Chen, Hsu-Heng Yen
Summary: This study analyzed the prevalence and clinical significance of MAFLD in Taiwanese IBD patients. The results showed that the prevalence of MAFLD in IBD was 29.2%, and 17.1% of them had significant liver fibrosis. Patients with MAFLD had a shorter disease duration, higher alanine aminotransferase levels, lower estimated glomerular filtration rate, and higher gamma-glutamyl transferase levels.
Article
Biochemistry & Molecular Biology
Chih-Wen Huang, Chen-Ta Yang, Pei-Yuan Su, Yang-Yuan Chen, Siou-Ping Huang, Hsu-Heng Yen
Summary: HBsAg seroclearance is uncommon in patients receiving long-term nucleos(t)ide analog therapy for hepatitis B virus infection. This study compared the incidence of HBsAg seroclearance in patients with and without NUC discontinuation and found a significantly higher incidence in patients who discontinued therapy.
Article
Health Care Sciences & Services
Chen-Cheng Chao, Hung-Yuan Lin, Chia-Yi Lee, Elsa Lin-Chin Mai, Ie-Bin Lian, Chao-Kai Chang
Summary: In this study, we compared the postoperative quality of vision in patients who received different types of intraocular lens implantation. The results showed that the monofocal group had the best postoperative visual acuity, while the EDOF group had worse contrast sensitivity. The quality of vision questionnaire also supported the better visual quality in the monofocal group.