期刊
EUROPEAN JOURNAL OF NUTRITION
卷 55, 期 3, 页码 1141-1151出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-015-0928-8
关键词
House dust mite; Asthma; Allergy; Oligosaccharides; Bifidobacterium breve
资金
- European Union
- European Regional Development Fund
- Ministry of Economic Affairs, Agriculture and Innovation
- Peaks in the Delta
- Municipality of Groningen
- Province of Groningen
- Province of Fryslan
- Province of Drenthe
- Dutch Carbohydrate Competence Center [CCC WP25]
- Nutricia Research
- FrieslandCampina
The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V (BB) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma. BALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with BB or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed. The HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and BB (FFBB). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-gamma and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FFBB reduced IL-6, IFN-gamma, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with BB was less potent in this model. These findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FFBB was most effective in the prevention of HDM-induced airway inflammation in mice.
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