Article
Agriculture, Multidisciplinary
Junjie Tan, Qingyu Ma, Jiao Li, Qiuming Liu, Yongliang Zhuang
Summary: The bioavailability of rambutan peel polyphenols (RPPs) was found to be high through in vitro simulated digestion and colonic fermentation, as evidenced by their transformation into various metabolites and their antioxidant and probiotic effects.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Food Science & Technology
Deming Looi, Mohanambal Moorthy, Nathorn Chaiyakunapruk, Uma Devi Palanisamy
Summary: The consumption of ellagitannin-rich fruits may have a significant effect in reducing diastolic blood pressure, especially in patients with hypertension and metabolic syndrome. There is a positive correlation between polyphenol dosage and changes in systolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Food Science & Technology
Min Shi, Hanjing Wu, Minhao Li, Ziyao Liu, Xinyu Duan, Colin Barrow, Frank Dunshea, Hafiz A. R. Suleria
Summary: Different varieties of lettuce have differences in the content, bioaccessibility, antioxidant properties, and production of short chain fatty acids (SCFAs) of phenolic compounds. Lollo rosso showed the highest content of phenolic compounds and exhibited high antioxidant capacities after gastrointestinal digestion. Baby cos and red little gem showed higher phenolic compound content after colonic fermentation. Most phenolic compounds in lettuce were bioaccessible after gastric and small intestinal digestion, except for kaempferol which relied more on colonic fermentation. All lettuce varieties achieved peak SCFA production after a certain time, with iceberg displaying the highest total SCFAs production at 8 hours fermentation.
Article
Food Science & Technology
Hanjing Wu, Colin Barrow, Frank R. Dunshea, Hafiz A. R. Suleria
Summary: Postharvest fermentation significantly affects the chemical profile and nutritional value of coffee beans. This study evaluated the effects of indigenous fermentation on both green and roasted coffee beans by measuring phenolic compounds, bioaccessibility, absorbability, antioxidant and enzyme inhibitory activities, and short-chain fatty acid (SCFA) production during digestion and fermentation. Fermented roasted coffee beans showed similar or lower phenolic content and antioxidant activity compared to unfermented beans. However, medium-roasted fermented beans exhibited higher enzyme inhibitory activities. Bioaccessibility and absorption of phenolics and chlorogenic acid were higher in fermented green coffee beans, but decreased with roasting due to thermal degradation. The total SCFA production from fermented beans was lower than unfermented beans due to polysaccharide hydrolyzation. Fermented coffee beans have higher nutritional value, especially in terms of phenolic absorption efficiency and antidiabetic potential.
Article
Biochemistry & Molecular Biology
Isabel Velasco-Ruiz, Elsy De Santiago, Jose Luis Ordonez-Diaz, Gema Pereira-Caro, Jose Manuel Moreno-Rojas
Summary: The impact of in vitro gastrointestinal digestion and colonic fermentation on polyphenol compounds from different varieties of pistachio was evaluated by UHPLC-HRMS analysis. The total polyphenol content significantly decreased during oral and gastric digestion, while there were no significant changes after the intestinal phase. In vitro digestion revealed that hydroxybenzoic acids and flavan-3-ols were the main compounds in pistachios. Colonic fermentation affected the total phenolic content, and several catabolites were identified after fecal fermentation. These catabolites may contribute to the health properties attributed to pistachio consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Deming Looi, Boon H. Goh, Shafi U. Khan, Nafees Ahemad, Uma D. Palanisamy
Summary: Hypertension, characterized by elevated blood pressure in the circulation system, is treatable with drugs like ACE inhibitors. Natural alternatives, such as dietary polyphenols derived from plant products like ellagitannins, have shown antihypertensive effects in experiments. Among these, ellagic acid has been found to exhibit similar inhibitory potential to ACE as the positive control captopril.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Mi-Ai Lee, Yun-Jeong Choi, Hyojung Lee, Sojeong Hwang, Hye Jin Lee, Sung Jin Park, Young Bae Chung, Ye-Rang Yun, Sung-Hee Park, Sunggi Min, Lee-Seung Kwon, Hye-Young Seo
Summary: This study investigated the effects of salinity on kimchi fermentation, revealing variations in characteristics and microbial community composition of kimchi samples at different salt concentrations.
FERMENTATION-BASEL
(2021)
Article
Food Science & Technology
Wolfram M. Brueck, Victor Daniel Diaz Escobar, Lindsay Droz-dit-Busset, Martine Baudin, Nancy Nicolet, Wilfried Andlauer
Summary: This study successfully liberated ellagic acid from ellagitannins through solid-state fermentation in walnut press cake. Walnut and press cake contain precursors for ellagic acid and urolithins, and the two molds traditionally used in Asia (A. oryzae and R. oligosporus) have the necessary enzymes to utilize the nutrients in the press cake.
Article
Environmental Sciences
Wang Li, Bo Zu, Lei Li, Jian Li, Jiawen Li, Xueyu Mei
Summary: This study investigated the desorption behavior of bisphenol A (BPA) from three types of microplastic materials under simulated gastrointestinal conditions. The results showed that BPA desorbed rapidly from microplastic carriers, with different desorption percentages for each type of material. The desorption behavior was influenced by the structure and functional groups of the polymers, as well as the pH and temperature of the digestive juices. These findings help to understand the potential health risks of exposure to microplastics and their sorbed pollutants in the environment.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Nutrition & Dietetics
Rurui Li, Zhenxing Wang, Kin Weng Kong, Ping Xiang, Xiahong He, Xuechun Zhang
Summary: The objective of this research was to investigate and compare the bioactivities and bioaccessibility of polyphenols from Dendrobium officinale (DO) and probiotic fermented Dendrobium officinale (FDO). The results showed that FDO had higher levels of total phenolic contents and total flavonoid contents compared to DO. The released compounds during digestion were different between DO and FDO. FDO demonstrated stronger antioxidant and inhibitory activities against digestive enzymes. Through colonic fermentation, FDO could alter intestinal microbial diversity and enrich beneficial bacteria.
FRONTIERS IN NUTRITION
(2022)
Review
Plant Sciences
Jingyan Li, Ruixue Liao, Shijia Zhang, Huimin Weng, Yuanzhi Liu, Tianyi Tao, Fengxu Yu, Guang Li, Jianming Wu
Summary: This study critically analyzed the literature available on ellagic acid (EA) and urolithins and their potential therapeutic effects in cardiovascular diseases (CVDs). The findings suggest that EA and urolithins could be used as valid candidates for early prevention and effective therapeutic strategies for various CVDs, including atherosclerosis, hypertension, myocardial infarction, cardiac fibrosis, cardiomyopathy, cardiac arrhythmias, and cardiotoxicities. Their mechanisms of action involve regulating lipid metabolism, inhibiting pro-inflammatory factors, preventing cell proliferation and apoptosis, improving endothelial function, and modulating calcium intake and release.
Article
Biochemistry & Molecular Biology
Juri Takayoshi, Yong-Lin Huang, Yosuke Matsuo, Yoshinori Saito, Dian-Peng Li, Takashi Tanaka
Summary: Ellagitannins (ETs) are plant polyphenols with health benefits. Insect tea from Guangxi region contains ET metabolites produced in the digestive tract of moth larvae and may have higher bioavailability than original ETs.
Article
Agricultural Engineering
Juan Buenrostro-Figueroa, Gerardo Gutierrez-Sanchez, Lilia A. Prado-Barragan, Raul Rodriguez-Herrera, Pedro Aguilar-Zarate, Leonardo Sepulveda, Juan A. Ascacio-Valdes, Julio C. Tafolla-Arellano, Cristobal N. Aguilar
Summary: The study aimed to obtain enzymatic extracts by Aspergillus niger GH1 in solid-state fermentation using dextrose and ellagitannins as inducers of ellagitannase, and found that phospholipase may be involved in ellagitannins biosynthesis.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Applied
Wenfei Tian, Ruijia Hu, Gengjun Chen, Yiqin Zhang, Weiqun Wang, Yonghui Li
Summary: The health benefits of whole wheat products are partly due to their unique phenolic compounds, which can be released through simulated digestion and probiotic fermentation. More phenolic acids were released in the first hour of digestion, and Lactobacillus rhamnosus GG released additional phenolic acids during fermentation. The digestion method seems to provide a better estimate of phenolic acid composition in whole wheat products compared to chemical extraction.
Article
Nutrition & Dietetics
Saleha Akter, Rama Addepalli, Michael Netzel, Ujang Tinggi, Mary Fletcher, Yasmina Sultanbawa, Simone Osborne
Summary: This study evaluated the bioaccessibility and intestinal absorption of Terminalia ferdinandiana compounds using in vitro models. The results showed an increase in the bioaccessibility of ellagic acid, oxalic acid, and calcium from the gastric phase to the intestinal phase. Additionally, variable rates of intestinal absorption were observed.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Rosa M. Lamuela-Raventos, Mariem Achour, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This systematic review summarizes human studies on the absorption, metabolism, distribution and excretion of dietary flavan-3-ols and their metabolites. Forty-nine intervention studies were included, and up to 180 metabolites were quantified in blood and urine samples after flavan-3-ol intake. The main compounds detected were phase 2 conjugates of microbial catabolites, with phenyl-gamma-valerolactones being the most representative ones. The bioavailability of flavan-3-ols was moderate, and it showed intra- and inter-source differences.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Donato Angelino, Aoife Caffrey, Helene McNulty, Chris I. R. Gill, Pedro Mena, Alice Rosi, Katie Moore, Leane Hoey, Michelle Clements, Eamon Laird, Kerrie Boyd, Brian Mullen, Bruna Pucci, Harry Jarrett, Conal Cunningham, Mary Ward, J. J. Strain, Kevin McCarroll, Adrian J. Moore, Anne M. Molloy, Daniele Del Rio
Summary: This study investigated the relationship between plasma phenyl-γ-valerolactones (PVLs) and self-reported intakes of total flavan-3-ols (F3O) and procyanidins+(epi)catechins. The results showed that two PVL metabolites were weakly associated with the intake of F3O and procyanidins+(epi)catechins. However, further controlled feeding studies are needed to validate plasma PVLs as biomarkers for these dietary polyphenols.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Food Science & Technology
Jaap Keijer, Xavier Escote, Sebastia Galmes, Andreu Palou-March, Francisca Serra, Mona Adnan Aldubayan, Kristina Pigsborg, Faidon J. Magkos, Ella C. Baker, Philip Calder, Joanna Goralska, Urszula Razny, Malgorzata Malczewska-Malec, David Sunol, Mar A. Galofre, Miguel Rodriguez, Nuria G. Canela, Radu Malcic, Montserrat Bosch, Claudia Favari, Pedro Mena, Daniele Del Rio, Antoni Caimari, Biotza M. Gutierrez, Josep del Bas
Summary: Personalized nutrition (PN) is a tool that empowers consumers to make dietary changes, improve health, and prevent diet-related diseases. However, the implementation of PN faces obstacles due to the complexity of individual metabolic characterization. This study proposes a conceptual framework that focuses on dysregulation of key processes and specific markers to assess metabolic health. Machine learning and data analysis algorithms can integrate omics and genetic markers, and digital tools can simplify their implementation.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Giulia Leni, Elia Romanini, Terenzio Bertuzzi, Alessio Abate, Letizia Bresciani, Milena Lambri, Margherita Dall'Asta, Mario Gabrielli
Summary: Italian grape ale (IGA) beers are made by adding grape or grape must during fermentation to provide additional characteristics. This study used must and pomace from the Malvasia di Candia Aromatica grape variety to produce IGA beers at different percentages. HPLC-MS/MS analysis showed that the addition of pomace significantly increased the total (poly)phenols in the beers, while must addition did not have the same effect. PCA cluster analysis demonstrated similarities among IGA beers and differentiated them from the control beer samples. This study highlights the improvement of the (poly)phenolic profile of beer through the addition of must and pomace from the MaCA grape variety.
Article
Food Science & Technology
Rossella Dodi, Giuseppe Di Pede, Cecilia Scarpa, Valeria Deon, Margherita Dall'Asta, Francesca Scazzina
Summary: The rate of starch digestion in the human intestine determines the glycemic response and glycemic index (GI) of foods. In vitro measurement of starch digestibility can reflect the GI. This study evaluated the differences in starch digestibility among different types of pasta, couscous, and bread to understand the impact of pasta-making processes. Statistical differences in rapidly digestible starch (RDS), slowly digestible starch (SDS), and resistant starch (RS) were found among the products. The results confirmed that pasta-making processes increase the content of SDS, which contributes to a lower glycemic response in vivo.
Article
Nutrition & Dietetics
Agnieszka Micek, Walter Currenti, Cristiana Mignogna, Alice Rosi, Ignazio Barbagallo, Ali A. Alshatwi, Daniele Del Rio, Pedro Mena, Justyna Godos
Summary: This study found that anthocyanins in 100% fruit juices may mediate the potential beneficial effects on blood lipids, with an increase in anthocyanins related to a decrease in total cholesterol and LDL cholesterol.
FRONTIERS IN NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Mariem Achour, Rosa M. Lamuela-Raventos, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Michael N. Clifford, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This work systematically assessed the pharmacokinetics, urinary recovery, and bioavailability of hydroxycinnamic acids (HCAs) and their metabolites. It was found that C-6-C-3 cinnamic acids, such as caffeic and ferulic acid, had the highest blood concentrations, while their excretion in urine was lower than hydroxybenzene catabolites. A comprehensive study investigating the ADME of HCAs from different dietary sources is urgently required.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Food Science & Technology
Nicole Tosi, Claudia Favari, Letizia Bresciani, Emma Flanagan, Michael Hornberger, Arjan Narbad, Daniele Del Rio, David Vauzour, Pedro Mena
Summary: This study aimed to quantify (Poly)phenol metabolites in plasma and urine following cranberry powder intake in healthy older adults and investigate individual differences by considering urinary metabotypes related to dietary (Poly)phenols. Cranberry consumption led to changes in plasma metabolites and individual variability in urinary metabolites, mainly driven by colonic metabolism. This metabotyping approach is significant for studying the health effects of cranberries and other (Poly)phenol-rich foods, particularly considering gut microbiota-driven individual differences.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Gema Pereira-Caro, Salud Caceres-Jimenez, Letizia Bresciani, Pedro Mena, Tahani M. Almutairi, Sara Dobani, L. Kirsty Pourshahidi, Chris I. R. Gill, Jose Manuel Moreno Rojas, Michael N. Clifford, Alan Crozier
Summary: This study investigated the phenolic catabolites excreted by fasting subjects with a functioning colon and ileostomists on a low (poly)phenol diet. The results showed that the potential sources of these substances include endogenous catecholamines, surplus tyrosine and phenylalanine, and catabolites derived from pre-study intakes of non-nutrient dietary (poly)phenols.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Antonio Costa-Perez, Vanesa Nunez-Gomez, Nieves Baenas, Giuseppe Di Pede, Mariem Achour, Claudine Manach, Pedro Mena, Daniele Del Rio, Cristina Garcia-Viguera, Diego A. Moreno, Raul Dominguez-Perles
Summary: This systematic review summarizes the findings of human studies on the metabolism and bioavailability of glucosinolates (GSL) and isothiocyanates (ITC), providing a comprehensive analysis for future research and consultation on this less studied area of GSL for food and health.
Article
Biochemistry & Molecular Biology
Jananee Muralidharan, Cindy Romain, Letizia Bresciani, Pedro Mena, Donato Angelino, Daniele Del Rio, Linda H. Chung, Pedro E. Alcaraz, Julien Cases
Summary: This study evaluated the nutrikinetics and bioavailability of a flavanone-rich product, Sinetrol (R) Xpur, in overweight and obese individuals. The results showed that while urinary excretion of metabolites decreased significantly over 16 weeks, there was no significant decrease in circulating metabolites. This suggests that chronic intake may not offer the same bioavailability as acute intake.
Review
Nutrition & Dietetics
Irene Rossi, Cristiana Mignogna, Daniele Del Rio, Pedro Mena
Summary: This review evaluates the impact of different types of 100% fruit and vegetable juices on human health, emphasizing the differences in bioactive compounds. While some juices have beneficial effects on cardiometabolic health outcomes, cognition, and exercise performance, they have no significant impact on anthropometric parameters and body composition. Further research is needed to better understand the effects of 100% fruit and vegetable juices on human health.
NUTRITION RESEARCH REVIEWS
(2023)