期刊
BENEFICIAL MICROBES
卷 8, 期 3, 页码 451-461出版社
WAGENINGEN ACADEMIC PUBLISHERS
DOI: 10.3920/BM2016.0186
关键词
gastritis; stomach; inflammation; probiotic; pathogenic bacteria; S. thermophilus CRL1190
资金
- German Academic Exchange Service DAAD
- German Research Foundation DFG (International Research Training Group Molecular and Cellular Glyco-Sciences MCGS, Munster Hyderabad) [1549]
This work evaluated the ability of the probiotic Streptococcus thermophilus CRL1190 strain and its exopolysaccharides to adhere to gastric mucosa. Probiotic bacteria attachment to the human stomach epithelium was confirmed in human stomach tissue samples and the gastric epithelial cell line AGS. In addition, it was demonstrated that S. thermophilus CRL1190 strain reduced Helicobacter pylori adhesion and attenuated inflammatory response in AGS cells. This is the first demonstration of the capacity of S. thermophilus CRL1190 to adhere to the stomach gastric mucosa, and improve protection against H. pylori through the reduction of its adhesion and the modulation of the inflammatory response. Therefore, S. thermophilus CRL1190 fermented milk is a good candidate for further in vivo studying of the protective effect of functional food against H. pylori infection and gastric inflammatory damage.
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