Article
Psychology, Clinical
Paul C. Donaghy, Joanna Ciafone, Rory Durcan, Calum A. Hamilton, Sally Barker, Jim Lloyd, Michael Firbank, Louise M. Allan, John T. O'Brien, John-Paul Taylor, Alan J. Thomas
Summary: MCI-LB is characterized by more neuropsychiatric symptoms compared to MCI-AD. The presence of two or more neuropsychiatric supportive symptoms as defined by MCI-LB diagnostic criteria is highly specific and moderately sensitive for a diagnosis of MCI-LB. The cognitive profile of MCI-LB differs from MCI-AD.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Hiroyuki Watanabe, Sakura Hikida, Manabu Ikeda, Etsuro Mori
Summary: This study aimed to determine the characteristics of aphasic mild cognitive impairment (aphasic MCI), which is characterized by a progressive and relatively prominent language impairment compared with other cognitive impairments, in the prodromal phase of dementia with Lewy bodies (DLB). The clinical diagnosis of probable prodromal DLB accounted for more than 30% of cases in the aphasic MCI cohort, and language impairment was not very uncommon in prodromal DLB. Patients with cholinesterase inhibitor therapy showed improvement in general cognitive function, including language function.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Jinghuan Gan, Shuai Liu, Zhichao Chen, Yaqi Yang, Lingyun Ma, Qingbo Meng, Xiao-Dan Wang, Chunyan Liu, Xudong Li, Wei Zhang, Yong Ji
Summary: Elevated plasma orexin-A levels were observed in patients with MCI-LB or DLB, while lower levels were found in DLB patients with fluctuating cognition or parkinsonism. Plasma orexin-A levels were associated with the presence of core features and motor and neuropsychiatric symptoms in patients with MCI-LB and DLB.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Paul C. C. Donaghy, Calum Hamilton, Rory Durcan, Sarah Lawley, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, Louise M. M. Allan, Ranjan Saha, Ian G. G. McKeith, John T. T. O'Brien, John-Paul Taylor, Alan J. J. Thomas
Summary: Through the investigation of patients with mild cognitive impairment with Lewy bodies (MCI-LB), it was found that MCI-LB patients have more symptoms, and a 10-point symptom scale can effectively differentiate MCI-LB and MCI-AD. These findings are important for clinicians to diagnose and treat MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Tahreem Ghazal Siddiqui, Timothy Whitfield, Sudhakar Janaki Praharaju, Dilman Sadiq, Hiba Kazmi, Aaron Ben-Joseph, Zuzana Walker
Summary: This study compared MRI measures in stable mild cognitive impairment patients, prodromal Alzheimer's disease, and prodromal dementia with Lewy bodies. It found that MTA scores at the stage of MCI already differ significantly between patients that progress to AD, DLB, or remain stable-MCI.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2021)
Article
Clinical Neurology
Alan J. Thomas, Calum A. Hamilton, Amanda Heslegrave, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Debbie Lett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Paul C. Donaghy, Henrik Zetterberg, John O'Brien
Summary: The study found that plasma pTau181 can serve as a blood-based biomarker for AD co-pathology and is associated with cognitive decline in patients with dementia with Lewy bodies and MCI with AD. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls, but was not useful in distinguishing probable MCI-LB from MCI-AD.
MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Paul C. Donaghy, Claudia Carrarini, Daniel Ferreira, Annegret Habich, Dag Aarsland, Claudio Babiloni, Ece Bayram, Joseph P. M. Kane, Simon J. G. Lewis, Andrea Pilotto, Alan J. Thomas, Laura Bonanni
Summary: This study conducted a systematic review and meta-analysis of the diagnostic clinical features and biomarkers in MCI-LB, supporting the inclusion of current clinical features in the diagnostic criteria and finding promise in FDG-PET and quantitative EEG as diagnostic biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Geriatrics & Gerontology
Calum A. Hamilton, James Frith, Paul C. Donaghy, Sally A. H. Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Louise M. Allan, John O'Brien, Alison J. Yarnall, Alan J. Thomas
Summary: This study aimed to compare the autonomic symptoms between the cognitive prodrome of Lewy body dementia (MCI-LB) and healthy older adults, as well as mild cognitive impairment due to Alzheimer's disease (MCI-AD). The study found that MCI-LB had more severe autonomic symptoms compared to normal aging and MCI-AD, but the autonomic symptoms were not specific to MCI-LB. The COMPASS-31 scale may have value as a sensitive screening test for early-stage Lewy body disease.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Jim Lloyd, George Petrides, Ian G. McKeith, Alan J. Thomas
Summary: The study found differences in cognitive profiles and progression between probable MCI-LB and MCI-AD, with MCI-LB patients showing less impaired recognition memory, greater initial impairments in verbal fluency and perception of line orientation, and an expedited decline in visuo-constructional functions. However, no clear diagnostic group differences were found in deterioration speeds for global cognition, language, overall memory, attention or other executive functions.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Frederic Blanc, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, Paulo Loureiro de Sousa, Pierre Krolak-Salmon, Renaud David, Clara Fischer, Jean-Francois Dartigues, David Wallon, Olivier Moreaud, Mathilde Sauvee, Catherine Belin, Sandrine Harston, Anne Botzung, Timothee Albasser, Catherine Demuynck, Izzie Namer, Marie-Odile Habert, Stephane Kremer, Olivier Bousiges, Marc Verny, Candice Muller, Nathalie Philippi, Genevieve Chene, Benjamin Cretin, Jean-Francois Mangin, Carole Dufouil
Summary: This study compared SCI and MCI patients with symptoms of prodromal DLB to other patients in terms of baseline characteristics. It was found that patients with symptoms of prodromal DLB had slower cognition, more behavioral disorders, autonomic symptoms, and photophobia. The brain MRI also showed specific involvement in certain brain areas.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neuroimaging
Julia Schumacher, John-Paul Taylor, Calum A. Hamilton, Michael Firbank, Ruth A. Cromarty, Paul C. Donaghy, Gemma Roberts, Louise Allan, Jim Lloyd, Rory Durcan, Nicola Barnett, John T. O'Brien, Alan J. Thomas
Summary: The study found that cholinergic degeneration in the MCI-LB stage is related to cognitive impairment severity. Early EEG slowing in MCI-LB might be partly cholinergically driven. These findings suggest an early cholinergic deficit in MCI-LB.
NEUROIMAGE-CLINICAL
(2021)
Article
Psychology, Clinical
Calum A. Hamilton, Fiona E. Matthews, Paul C. Donaghy, John-Paul Taylor, John T. O'Brien, Nicola Barnett, Kirsty Olsen, Ian G. McKeith, Alan J. Thomas
Summary: The study identified three distinct cognitive trajectories in individuals with MCI: slow/stable progression, intermediate progressive decline, and a small group with rapid decline. The presence of LB symptoms, particularly visual hallucinations, predicted decline in cognitive function. Identifying individuals with rapid decline is important for early intervention, although further research with larger cohorts is needed.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
Francois Quesque, Antoine Coutrot, Sharon Cox, Leonardo Cruz de Souza, Sandra Baez, Juan Felipe Cardona, Hannah Mulet-Perreault, Emma Flanagan, Alejandra Neely-Prado, Maria Florencia Clarens, Luciana Cassimiro, Gada Musa, Jennifer Kemp, Anne Botzung, Nathalie Philippi, Maura Cosseddu, Catalina Trujillo-Llano, Johan Sebastian Grisales-Cardenas, Sol Fittipaldi, Nahuel Magrath Guimet, Ismael Luis Calandri, Lucia Crivelli, Lucas Sedeno, Adolfo M. Garcia, Fermin Moreno, Begona Indakoetxea, Alberto Benussi, Millena Vieira Brandao Moura, Hernando Santamaria-Garcia, Diana Matallana, Galina Pryanishnikova, Anna Morozova, Olga Iakovleva, Nadezda Veryugina, Oleg Levin, Lina Zhao, Junhua Liang, Thomas Duning, Thibaud Lebouvier, Florence Pasquier, David Huepe, Myriam Barandiaran, Andreas Johnen, Elena Lyashenko, Ricardo F. Allegri, Barbara Borroni, Frederic Blanc, Fen Wang, Monica Sanches Yassuda, Patricia Lillo, Antonio Lucio Teixeira, Paulo Caramelli, Carol Hudon, Andrea Slachevsky, Agustin Ibanez, Michael Hornberger, Maxime Bertoux
Summary: Measures of social cognition are essential in neuropsychology for diagnoses and rehabilitation. International collaborations help tackle global mental health challenges, but differences between countries should not be ignored.
Letter
Medicine, General & Internal
Odile Launay, Marine Cachanado, Liem B. Luong Nguyen, Laetitia Ninove, Marie Lachatre, Ines Ben Ghezala, Marc Bardou, Catherine Schmidt-Mutter, Karine Lacombe, Fabrice Laine, Jean-Sebastien Allain, Elisabeth Botelho-Nevers, Marie-Pierre Tavolacci, Christian Chidiac, Patricia Pavese, Bertrand Dussol, Stephane Priet, Dominique Deplanque, Amel Touati, Laureen Curci, Eleine Konate, Nadine Ben Hamouda, Anissa Besbes, Eunice Nubret, Florence Capelle, Laurence Berard, Alexandra Rousseau, Eric Tartour, Tabassome Simon, Xavier de Lamballerie
Summary: In a small trial, boost immunization with beta-adjuvanted spike proteins resulted in the highest levels of antibodies and activated T cells after two weeks.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Frederic Blanc, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, Paulo Loureiro de Sousa, Pierre Krolak-Salmon, Renaud David, Clara Fischer, Jean-Francois Dartigues, David Wallon, Olivier Moreaud, Mathilde Sauvee, Catherine Belin, Sandrine Harston, Anne Botzung, Timothee Albasser, Catherine Demuynck, Izzie Namer, Marie-Odile Habert, Stephane Kremer, Olivier Bousiges, Marc Verny, Candice Muller, Nathalie Philippi, Genevieve Chene, Benjamin Cretin, Jean-Francois Mangin, Carole Dufouil
Summary: This study compared SCI and MCI patients with symptoms of prodromal DLB to other patients in terms of baseline characteristics. It was found that patients with symptoms of prodromal DLB had slower cognition, more behavioral disorders, autonomic symptoms, and photophobia. The brain MRI also showed specific involvement in certain brain areas.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Vincent Planche, Vincent Bouteloup, Isabelle Pellegrin, Jean-Francois Mangin, Bruno Dubois, Pierre-Jean Ousset, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Karim Bennys, Mathieu Ceccaldi, Cedric Annweiler, Pierre Krolak-Salmon, Olivier Godefroy, David Wallon, Mathilde Sauvee, Claire Boutoleau-Bretonniere, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Genevieve Chene, Carole Dufouil
Summary: Blood biomarkers for Alzheimer's disease can effectively discriminate AD from other neurodegenerative diseases and may serve as hallmarks of underlying pathology, but they add little to 5-year dementia risk prediction models.
Article
Geriatrics & Gerontology
Anais Falque, Melanie Jordanis, Lionel Landre, Paulo Loureiro de Sousa, Mary Mondino, Emmanuelle Furcieri, Frederic Blanc
Summary: This study investigates the impairment of narrative discourse comprehension in patients with dementia with Lewy bodies (DLB). The results suggest that DLB patients have difficulty understanding and organizing narrative discourse, which is associated with their executive dysfunction and reduced gray matter volume in the striatum.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Clinical Neurology
Benjamin Cretin, Nathalie Philippi, Olivier Bousiges, Frederic Blanc
Summary: This study found that CSF sampling has good diagnostic value in TEA patients with characteristics suggestive of incipient degenerative diseases. It suggests that TEA may be the inaugurating feature in some cases of AD. The results also demonstrate the etiological heterogeneity in TEA.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Anna Inguanzo, Konstantinos Poulakis, Rosaleena Mohanty, Christopher G. Schwarz, Scott A. Przybelski, Patricia Diaz-Galvan, Val J. Lowe, Bradley F. Boeve, Afina W. Lemstra, Marleen van de Beek, Wiesje van der Flier, Frederik Barkhof, Frederic Blanc, Paulo Loureiro de Sousa, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Zuzana Nedelska, Jakub Hort, Barbara Segura, Carme Junque, Ketil Oppedal, Dag Aarsland, Eric Westman, Kejal Kantarci, Daniel Ferreira
Summary: Using MRI data, we identified three subtypes of Dementia with Lewy bodies (DLB): older subtype with reduced cortical GM volumes and worse cognition, subtype with low GM volumes in fronto-occipital regions, and a younger subtype with the highest cortical GM volumes, lower GM volumes in basal ganglia, and cognitive fluctuations. These subtypes have implications for clinical practice, research, and treatment decisions.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Manon Querry, Frederic Blanc, Olivier Bousiges, Nathalie Philippi, Benjamin Cretin, Catherine Demuynck, Candice Muller, Anne Botzung
Summary: The aim of this study was to describe the characteristics and evolution of the long-term memory profile of patients with prodromal and mild DLB and AD. The study found that DLB patients performed better than AD patients in terms of total recall, delayed total recall, recognition, and loss of information over time. The memory performance of DLB patients remained stable over 48 months, unlike that of AD patients. Four indicators were relevant to distinguish between DLB and AD patients in terms of memory performance.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychiatry
Candice Muller, Jeanne Merignac, Christophe Moog, Benoit Schorr, Herve Javelot, Frederic Blanc
Summary: This study describes three patients with DLB who presented with major visual hallucinations, delusion, and an orbitofrontal syndrome. They were intolerant of low-dose clozapine and were treated with a combination of pimavanserin and trazodone. After 4 to 6 weeks of treatment, a marked improvement in symptoms was observed.
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2023)
Review
Biology
Alice Tisserand, Nathalie Philippi, Anne Botzung, Frederic Blanc
Summary: This review explores the relationship between the insula, a brain region, and the self. The insula is a multiconnected region that processes diverse information related to the self. Studies in healthy individuals and those with different conditions reveal the involvement of the insula in various aspects of the self. Damage to the insular cortex may lead to a collapse of the self across different pathologies.
Article
Clinical Neurology
Maria Camila Gonzalez, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Backstrom, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad Rejdak, Ewa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquie, Merce Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole-Bjorn Tysnes, Dag Aarsland, Jodi Maple-Grodem
Summary: This study compares the rate of cognitive and motor decline in patients with DLB and PDD, finding that both disorders show similar rates of decline. This has implications for future clinical trial designs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Leslie Grasset, Vincent Planche, Vincent Bouteloup, Chabha Azouani, Bruno Dubois, Frederic Blanc, Claire Paquet, Renaud David, Catherine Belin, Therese Jonveaux, Adrien Julian, Jeremie Pariente, Jean-Francois Mangin, Genevieve Chene, Carole Dufouil, Memento Cohort Study Grp
Summary: This study examines whether physical activity can moderate the association between biomarkers of brain pathologies and dementia risk. The results show that individuals who engage in high-intensity physical activity have weaker associations with brain pathologies and a lower risk of developing dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medical Laboratory Technology
Sylvain Lehmann, Susanna Schraen-Maschke, Jean-Sebastien Vidal, Constance Delaby, Frederic Blanc, Claire Paquet, Bernadette Allinquant, Stephanie Bombois, Audrey Gabelle, Olivier Hanon, BALTAZAR Study Grp
Summary: This study compared the clinical performance of Lumipulse and Simoa assays in predicting the conversion to dementia in patients with mild cognitive impairment (MCI). The results showed that both assays had similar abilities, but Lumipulse was less affected by comorbidities. Plasma pTau181 was associated with renal dysfunction, cardiovascular factors, nutrition, and inflammatory markers. The study suggests that Lumipulse could be used as a noninvasive diagnostic tool for the management of Alzheimer's disease.
CLINICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Vincent Planche, Vincent Bouteloup, Isabelle Pellegrin, Jean-Francois Mangin, Bruno Dubois, Pierre-Jean Ousset, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Karim Bennys, Mathieu Ceccaldi, Cedric Annweiler, Pierre Krolak-Salmon, Olivier Godefroy, David Wallon, Mathilde Sauvee, Claire Boutoleau-Bretonniere, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Genevieve Chene, Carole Dufouil, MEMENTO Study Grp
Summary: In a clinic-based cohort of patients with subjective cognitive complaint or mild cognitive impairment, blood biomarkers may serve as good indicators of underlying pathology but do not contribute significantly to 5-year dementia risk prediction models that include traditional predictors.