Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer’s disease by regulating cilia function

Investigational drugs targeting 5-HT6 receptors for the treatment of Alzheimer’s disease

(2015) Karsten Wicke et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation

(2015) P. J. Yao et al.   JOURNAL OF NEUROSCIENCE

The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism

(2014) M. Jacobshagen et al.   DEVELOPMENT

Safety and efficacy of idalopirdine, a 5-HT 6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial

(2014) David Wilkinson et al.   LANCET NEUROLOGY

The primary cilium

(2014) Andrew M Fry et al.   Organogenesis

Arborization of Dendrites by Developing Neocortical Neurons Is Dependent on Primary Cilia and Type 3 Adenylyl Cyclase

(2013) S. M. Guadiana et al.   JOURNAL OF NEUROSCIENCE

Psychological, cognitive and maternal stress assessment in children with primary ciliary dyskinesia

(2013) Marco Carotenuto et al.   World Journal of Pediatrics

Reduction of the immunostainable length of the hippocampal dentate granule cells’ primary cilia in 3xAD-transgenic mice producing human Aβ1-42 and tau

(2012) Balu Chakravarthy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Arl13b in Primary Cilia Regulates the Migration and Placement of Interneurons in the Developing Cerebral Cortex

(2012) Holden Higginbotham et al.   DEVELOPMENTAL CELL

Hippocampal dysgenesis and variable neuropsychiatric phenotypes in patients with Bardet-Biedl syndrome underline complex CNS impact of primary cilia

(2011) V Bennouna-Greene et al.   CLINICAL GENETICS

Primary Cilia Regulate Proliferation of Amplifying Progenitors in Adult Hippocampus: Implications for Learning and Memory

(2011) A. Amador-Arjona et al.   JOURNAL OF NEUROSCIENCE

The Type 3 Adenylyl Cyclase Is Required for Novel Object Learning and Extinction of Contextual Memory: Role of cAMP Signaling in Primary Cilia

(2011) Z. Wang et al.   JOURNAL OF NEUROSCIENCE

Cilia in the CNS: The Quiet Organelle Claims Center Stage

(2011) Angeliki Louvi et al.   NEURON

Loss of Bardet-Biedl syndrome protein-8 (BBS8) perturbs olfactory function, protein localization, and axon targeting

(2011) A. L. D. Tadenev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatostatin Signaling in Neuronal Cilia Is Criticalfor Object Recognition Memory

(2010) E. B. Einstein et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability

(2010) Matthew S. Grubb et al.   NATURE

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

Joubert Syndrome: Insights Into Brain Development, Cilium Biology, and Complex Disease

(2009) Dan Doherty   Seminars in Pediatric Neurology

Developmental changes in frequency of the ciliary somatostatin receptor 3 protein

(2008) Davor Stanić et al.   BRAIN RESEARCH

AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity

(2008) Kristian L. Hedstrom et al.   JOURNAL OF CELL BIOLOGY

5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer’s disease

(2008) Neil Upton et al.   Neurotherapeutics