Article
Biochemistry & Molecular Biology
Wei Chen, Mingyang Ma, Qingteng Lai, Yanke Zhang, Zhengchun Liu
Summary: A simple pH and redox dual stimuli-responsive diketopyrrolopyrrole (DPP)-Cu2+ complexes gated mesoporous silica nanoparticles (MSN) were prepared for precise drug delivery and controlled drug release. The MSN-DPP-Cu2+ showed good blocking effect under physiological conditions and responded well to the pH and redox glutathione (GSH) dual stimuli. In vitro cytotoxicity assay demonstrated that the MSN-DPP-Cu2+ had good biocompatibility and efficient drug release in Hep G2 cells.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Yunhao Gao, Yu Liu, Xueyin Qin, Ziping Guo, Donglin Li, Chenggang Li, Hu Wan, Fuxing Zhu, Jianhong Li, Zhuo Zhang, Shun He
Summary: The study presented controlled-release formulations with pH/cellulase dual stimuli responsiveness for efficient fungicidal activity against Magnaporthe oryzae and reduced genotoxicity of pyraclostrobin. These formulations are promising for sustainable crop disease protection.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Tao Liao, Chang Liu, Jun Ren, Hui Chen, Ying Kuang, Bingbing Jiang, Jianli Chen, Zhengguang Sun, Cao Li
Summary: In this study, a dual-pH-sensitive chitosan/mesoporous silica nanoparticle-based anticancer drug delivery system was developed using the tumor-triggered targeting strategy. Both in vitro and in vivo studies demonstrated that the system could induce cancer cell apoptosis, inhibit tumor growth, and reduce the cytotoxicity of the drug against normal cells, showing potential for cancer therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Yuzhe Sun, Edward W. Davis
Summary: A tubular-shaped Janus nanoparticle based on polydopamine that responds to near-infrared, magnetic, and pH stimuli is reported. The robust tubular polydopamine structure was obtained by optimizing the halloysite template-to-dopamine ratio during synthesis. The inner and outer surfaces of the tube were exposed at different steps of the template-sonication-etching process, enabling the differential surface modification of these surfaces. The resulting magnetic Janus nanoparticles responded to pH, temperature, and magnetic fields, and the release rates of adsorbed doxorubicin from the nanoparticles were influenced by these stimuli.
Review
Pharmacology & Pharmacy
Thashini Moodley, Moganavelli Singh
Summary: Cancer remains a devastating non-communicable disease with increasing incidence and mortality rates. The development of novel therapeutic strategies using multimodal nanotechnology is critical in enhancing therapeutic outcomes and overcoming resistance. Mesoporous silica nanoparticles have shown promising potential in cancer therapy with their stimuli-responsive controlled release functions and increased bioavailability.
Article
Materials Science, Biomaterials
Zhengguo Chen, Wangting Zhou, Yujing Wei, Lingling Shi, Zhaoxia Zhang, Mehran Dadgar, Guocheng Zhu, Guoqing Zhang
Summary: A novel NIR light-triggered temperature-sensitive drug delivery system has been developed for controllable release of drug. This system uses a phase change material as a drug carrier and releases the drug through a solid-liquid transition upon temperature change. Experimental results demonstrate the effectiveness and controllability of this system.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Pharmacology & Pharmacy
Nicolas Jackson, Andrea C. C. Ortiz, Alejandro Jerez, Javier Morales, Francisco Arriagada
Summary: Stimuli-responsive nanomaterials have been studied as a promising strategy for anticancer therapy, with pH-responsive silica nanocarriers being particularly effective in controlled drug delivery in acidic tumor microenvironments. The design of the nanocarrier and drug release mechanisms play a crucial role in optimizing efficacy, and this study provides new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem.
Article
Pharmacology & Pharmacy
Mengru Chen, Yunyun Chen, Yanbao Zhao, Xueyan Zou, Lei Sun
Summary: In this study, three types of mesoporous silica nanoparticles with different aspect ratios were prepared. The samples showed that aspect ratio affects specific surface area, cell uptake rate, and drug loading capacity. The MS3 sample, with higher cell uptake rate and specific surface area, was used as a carrier for drug delivery system, displaying redox/pH-responsive and sustained release behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Yingnan Zhang, Changhao Fang, Wildemar S. P. Carvalho, Yongfeng Gao, Michael J. Serpe
Summary: The light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) microgels demonstrated efficient release of fluorescein through UV irradiation-induced cleavage and heating-induced deswelling, showing potential applications in triggered cargo release systems.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Zhongtao Li, Jing Guo, Guiqiang Qi, Meng Zhang, Liguo Hao
Summary: A pH-responsive and imaging nanocarriers system using mesoporous silica nanoparticles (MSNs) doped with gadolinium (Gd) was developed. The system showed pH-responsiveness and high biocompatibility, and the T1 contrast was significantly enhanced by Gd, making it a promising system for cancer diagnosis and treatment.
Article
Chemistry, Multidisciplinary
Hua Pan, Weilan Huang, Litao Wu, Qihao Hong, Zhongxuan Hu, Meijing Wang, Fang Zhang
Summary: Integrating pesticides and mineral elements into a multi-functional nanocarrier can synergistically protect plants and provide nutrients. The pH dual-responsive nanosystem developed in this study effectively delivered a fungicide to target organisms and promoted plant growth, while showing no obvious toxicological influence on bacteria and cell viability.
Review
Pharmacology & Pharmacy
Tao Sun, Chen Jiang
Summary: Drug delivery systems (DDS) triggered by local microenvironment represent the state-of-art of nanomedicine design, aiming to precisely recognize diseased sites, reduce side effects, and expand the therapeutic window. However, the design of DDS functioning at microcosmic levels is still challenging and underexploited.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Physical
Litao Wu, Hua Pan, Weilan Huang, Zhongxuan Hu, Meijing Wang, Fang Zhang
Summary: In this study, Prochloraz controlled-release nanoparticles based on bimodal mesoporous silica with redox and pH dual responses were successfully prepared. The nanoparticles showed excellent release performance under acidic conditions, good antifungal activity, and benign biosafety. This work provides a promising approach to improving the efficient utilization of pesticides and reducing environmental pollution.
Article
Polymer Science
Ngoc-Hang Truong-Thi, Ngoc Hoi Nguyen, Dinh Tien Dung Nguyen, Tuan Ngan Tang, Thi Hiep Nguyen, Dai Hai Nguyen
Summary: In this study, a drug delivery system based on mesoporous silica nanoparticles modified with heparin was fabricated to achieve sustainable and pH-responsive release of Platinum-based drugs. The modified nanoparticles showed high uniform spherical shape with a diameter of 89.03 +/- 4.49 nm, and had a loading capacity of cisplatin twice as the bare nanoparticles. The amount of drug released in tumor microenvironment (pH 5.8) was significantly higher than that released in physiological environment (pH 7.4). Cell toxicity assay confirmed the biocompatibility of the modified nanoparticles on MCF-7 cells. These results suggest that the heparin-modified nanoparticles have great potential as nanocarriers for chemotherapy with effectively loading ability and sustained release of Platinum-based drugs with pH response.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Environmental
Yingjian Ma, Yinmin Wang, Rui Zhao, Zhijie Wang, Shuang Li, Meng Yu, Sen Pang, Xinyu Guo, Yong Xu, Xuemin Wu
Summary: Using advanced functional materials and technologies to construct new, efficient, and controlled-release pesticide formulations can effectively improve the target utilization of pesticides and reduce their impact on nontarget organisms and the surrounding environment. The study presents a strategy for preparing pH-responsive nanodrug delivery systems that can release pesticides rapidly in acidic environments. The results show that the nanodrug delivery system has longer-lasting fungicidal activity and lower impact on non-target organisms and the environment. Moreover, it can provide trace elements required by plants to promote crop growth without disturbing normal growth.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Orthopedics
Henrik C. Baecker, Chia H. Wu, Arne Kienzle, Carsten Perka, Clemens Gwinner
Summary: This study aimed to identify mechanical failures in total hip arthroplasties performed at a major academic center and their associated risk factors. The results showed that there were different types of mechanical failures in 13 patients, and they were not related to participation in sports or BMI. Therefore, it is important to assess and screen patients for risk factors before surgery.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Nils-Jorgen K. Dai, Gabriela Schaefer, Andrew M. Thompson, Sascha Schmitt, Natalja Redinger, Noelia Alonso-Rodriguez, Kerstin Johann, Jessica Ojong, Jens Wohlmann, Andreas Best, Kaloian Koynov, Rudolf Zentel, Ulrich E. Schaible, Gareth Griffiths, Matthias Barz, Federico Fenaroli
Summary: Tuberculosis is a deadly bacterial disease that threatens millions of lives each year. In this study, polymeric micelles were used to encapsulate four derivatives of the antitubercular drug pretomanid, which showed better in vivo activity against Mycobacterium tuberculosis. These micelles overcame the hydrophobicity and limited bioavailability of the compounds, reducing toxicities and improving therapeutic outcomes.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Shen Han, Richard da Costa Marques, Johanna Simon, Anke Kaltbeitzel, Kaloian Koynov, Katharina Landfester, Volker Mailaender, Ingo Lieberwirth
Summary: Protein corona formation on nanoparticles in biological environments plays a crucial role in determining endocytosis, cellular processes, and drug release. However, little is known about the fate of the protein corona inside cells. This study demonstrates the separation and different processing of nanoparticles and protein corona within different cellular compartments, leading to the conclusion that nanoparticles are prepared for subsequent exocytosis while the protein corona remains in the cell and is ultimately metabolized.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Ryan J. Murphy, Gency Gunasingh, Nikolas K. Haass, Matthew J. Simpson
Summary: The author explores the discrepancy between experimental conditions and in vivo conditions by growing tumour spheroids under time-dependent oxygen conditions and identifies novel biological adaptation mechanisms. The study reveals transient reversal of tumour spheroid growth phases and unexpected necrotic core removal. By extending the Greenspan mathematical model, the biological mechanisms governing tumour spheroid growth in time-dependent oxygen conditions are revealed.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tobias A. A. Bauer, Jonas Schramm, Federico Fenaroli, Svenja Siemer, Christine I. I. Seidl, Christine Rosenauer, Regina Bleul, Roland H. H. Stauber, Kaloian Koynov, Michael Maskos, Matthias Barz
Summary: The efficient manufacturing techniques are necessary for translating innovative nanomaterials into medical products, requiring large-scale high-throughput synthesis with high reproducibility. A continuous flow process is reported for synthesizing pro-drug-loaded core cross-linked polymeric micelles, combining the commonly separated steps into a single process. The microfluidic process allows the production of spherical micelles with low polydispersity values, avoiding toxic solvents and additives. The formed paclitaxel-loaded CCPMs possess pH-responsive release and show improved toxicity profile and therapeutic efficiency.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Maximilian Scherger, Yannick A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Kaloian Koynov, Hans Joachim Raeder, Lutz Nuhn
Summary: The reversible addition-fragmentation chain-transfer (RAFT) polymerization allows the synthesis of biocompatible and functional macromolecules for polymer-drug conjugates. By utilizing traceless linkers, the drug conjugates can be reversibly attached to and released from the polymer chain. This approach is particularly relevant for poly(N,N-dimethylacrylamide) (pDMA), which has shown similar properties to poly(ethylene glycol) (PEG) in improving drug pharmacokinetics and bioavailability. The incorporation of various functionalities in a one-pot reaction procedure has been demonstrated, along with reversible conjugation and traceless release. Moreover, the internalization of polymer-drug conjugates at the cellular level has been achieved using cholesterol-modified RAFT chain-transfer agents.
Review
Oncology
B. W. M. Thilini J. Basnayake, Paul Leo, Sudha Rao, Sarju Vasani, Lizbeth Kenny, Nikolas K. K. Haass, Chamindie Punyadeera
Summary: Head and neck cancers (HNC) are a heterogeneous group of malignancies arising in various anatomical sites within the head and neck region. Patient-derived cancer organoids, or tumouroids, have been developed as in vitro model systems that replicate in vivo tumor characteristics. These tumouroids can play an essential role in bringing precision medicine for highly heterogeneous cancer types such as HNC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Dermatology
Courtney K. Wallingford, Anastassia Demeshko, Asha Krishnankutty Krishnakripa, Darren J. Smit, David L. Duffy, Brigid Betz-Stablein, Annette Pflugfelder, Kasturee Jagirdar, Elizabeth Holland, Graham J. Mann, Clare A. Primiero, Tatiane Yanes, Josep Malvehy, Celia Badenas, Cristina Carrera, Paula Aguilera, Catherine M. Olsen, Sarah Ward, Nikolas K. Haass, Richard A. Sturm, Susana Puig, David C. Whiteman, Matthew H. Law, Anne E. Cust, Miriam Potrony, H. Peter Soyer, Aideen M. McInerney-Leo
Summary: Genetic characterization can improve cost-effectiveness of melanoma screening. The interactions between MC1R RHC variants and MITF E318K in melanoma risk have not been well explored. This study found that while all MC1R RHC genotypes increase melanoma risk in E318K(-) individuals, only the MC1R R genotype increases melanoma risk in E318K(+) individuals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hsiao-Ping Hsu, Manjesh K. Singh, Yu Cang, Heloise Therien-Aubin, Markus Mezger, Ruediger Berger, Ingo Lieberwirth, George Fytas, Kurt Kremer
Summary: A new method for creating nanoporous polymer membranes with well defined pore diameters is introduced, which involves mechanical deformation and quenching of highly entangled polymer films. The approach is validated using polystyrene films and does not require chemical processing, supporting substrate, or self-assembly. The resulting membranes exhibit stable properties and impressive elasticity, with pore diameters on the order of ten polymer reptation tube diameters.
Review
Immunology
Yi Ren, Henrik Baecker, Michael Mueller, Arne Kienzle
Summary: The immune system has a significant impact on bone metabolism in various pathological and inflammatory conditions. Myeloid-derived suppressor cells (MDSCs) are a group of cells that can suppress immune responses and mediate bone remodeling. They can both cause bone erosion through differentiation into osteoclasts and alleviate immune reactions. This review discusses the influence of MDSCs on bone metabolism and potential therapeutic targets for improving bone health.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tobias A. A. Bauer, Irina Alberg, Lydia A. A. Zengerling, Pol Besenius, Kaloian Koynov, Bram Slutter, Rudolf Zentel, Ivo Que, Heyang Zhang, Matthias Barz
Summary: Core cross-linked polymeric micelles (CCPMs) are designed to improve the therapeutic profile of hydrophobic drugs, reduce or completely avoid protein corona formation, and offer prolonged circulation times. CCPM stability was tuned by using bifunctional or trifunctional cross-linkers and varying the cross-linkable polymer block length. The circulation time and biodistribution of CCPMs can be enhanced by using trivalent peptide cross-linkers.
Article
Pharmacology & Pharmacy
Dinoop Ravindran Menon, Heinz Hammerlindl, Gregory Gimenez, Sabrina Hammerlindl, Elmar Zuegner, Joachim Torrano, Natalie Bordag, Abdullah Al Emran, Maybelline Giam, Simon Denil, Norman Pavelka, Aik-Choon Tan, Richard A. Sturm, Nikolas K. Haass, Giulia Rancati, Meenhard Herlynj, Christoph Magnes, Michael R. Eccles, Mayumi Fujitab, Helmut Schaider
Summary: This study explores the mechanism of adaptive drug resistance and identifies OGT as a key regulator of DTPPs. The findings suggest that OGT plays a role in cancer cell reprogramming towards acquired drug resistance. Understanding this mechanism may help improve response duration and patient outcomes.
DRUG RESISTANCE UPDATES
(2023)
Article
Pharmacology & Pharmacy
Maximilian Scherger, Yannick A. A. Pilger, Judith Stickdorn, Patric Komforth, Sascha Schmitt, Sana M. M. Arnouk, Els Lebegge, Kaloian Koynov, Hans-Joachim Rader, Jo A. A. Van Ginderachter, Lutz Nuhn
Summary: In this study, a procedure is demonstrated for site-specific reversible bioconjugation of genetically engineered single domain antibodies, called nanobodies, using self-immolative linkers (SILs). The flow cytometry and microscopy images confirm cellular uptake and biological affinity of the modified nanobodies. This strategy can be extended to other therapeutically relevant representatives of nanobodies, highlighting the versatility of this reversible reductive-responsive bioconjugation in a broad field of applications.
ADVANCED THERAPEUTICS
(2023)
Article
Orthopedics
Alexander M. H. Kunde, J. Turner Vosseller, Michael Dahne, Arne Kienzle, Henrik C. Baecker
Summary: This study aims to reduce the need for MRI scans in diagnosing acute isolated syndesmotic injuries (AISIs) by improving conventional radiography and CT imaging. The results suggest that the syndesmotic area (SA) measured on CT scans is the most significant parameter, with high sensitivity and specificity. Radiographic imaging could be an equally accurate and faster alternative to MRI in diagnosing AISIs.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Review
Orthopedics
Henrik C. Baecker, John T. Richards, Arne Kienzle, John Cunningham, Karl F. Braun
Summary: Exertional rhabdomyolysis is a condition in which skeletal muscle cells break down after intense exercise, leading to increased levels of creatine kinase (CK) or myoglobin, as well as blood in the urine, and potentially kidney insufficiency. This study aimed to outline the current perspectives on exertional rhabdomyolysis in athletes and the subsequent treatment options based on existing literature.
CLINICAL JOURNAL OF SPORT MEDICINE
(2023)
