期刊
ADVANCED HEALTHCARE MATERIALS
卷 6, 期 22, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201701021
关键词
3D printing; bioinks; memory-shape implants; patient-specific; silk fibroin; tissue engineering
资金
- Portuguese Foundation for Science and Technology (FCT) through the project B-FABULUS [PTDC/BBB-ECT/2690/2014]
- FCT/MCTES [PD/BD/113803/2015]
- program Investigador FCT [IF/00115/2015, IF/00423/2012, IF/01285/2015]
- Fundação para a Ciência e a Tecnologia [PTDC/BBB-ECT/2690/2014, PD/BD/113803/2015] Funding Source: FCT
The pursuit for the perfect biomimetic and personalized implant for musculoskeletal tissue regeneration remains a big challenge. 3D printing technology that makes use of a novel and promising biomaterials can be part of the solution. In this study, a fast setting enzymatic-crosslinked silk fibroin (SF) bioink for 3D bioprinting is developed. Their properties are fine-tuned and different structures with good resolution, reproducibility, and reliability can be fabricated. Many potential applications exist for the SF bioinks including 3D bioprinted scaffolds and patient-specific implants exhibiting unique characteristics such as good mechanical properties, memory-shape feature, suitable degradation, and tunable pore architecture and morphology.
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