Review
Oncology
Ayesha Hassan, Roberto Carmagnani Pestana, Amanda Parkes
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are rare mesenchymal neoplasms that pose a therapeutic challenge due to lack of effective targeted therapy. Although standard chemotherapy regimens exist, there is a particular need for novel therapeutic strategies, especially for neurofibromatosis type 1 (NF1)-associated MPNST.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Matthieu Peyre, Suzanne Tran, Beatrice Parfait, Isabelle Bernat, Franck Bielle, Michel Kalamarides
Summary: Neurofibromatosis type 2 (NF2) is a rare genetic disorder characterized by central nervous system lesions, but it can also lead to peripheral nerve pathology causing pain and sensory loss. This study investigated the tumor burden of peripheral nerve pathology in NF2 patients and found that surgery is a safe and effective method for treating peripheral nerve schwannomas-associated pain in NF2, except for rare multinodular tumors.
Article
Surgery
Yan Zhang, Hongfei Cai, Guangchao Lv, Yang Li
Summary: The article reports a case of a female patient with neurofibroma on body surfaces and MPNST in the posterior mediastinum. Following surgical resection, there was no tumor relapse in the lungs, indicating the importance of timely surgery and detailed examination in improving tumor diagnostic accuracy.
Review
Oncology
Jordan Jones, Sarah Cain, Jonathan Pesic-Smith, Peter F. M. Choong, Andrew P. Morokoff, Kate J. Drummond, Gabriel Dabscheck
Summary: The main cause of early death in NF1 patients is MPNST. Current methods for diagnosis and monitoring are inadequate, but ctDNA shows promise in improving patient care.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Oncology
Sumanth Nagabushan, Loretta M. S. Lau, Paulette Barahona, Marie Wong, Alexandra Sherstyuk, Glenn M. Marshall, Vanessa Tyrrell, Eva A. Wegner, Paul G. Ekert, Mark J. Cowley, Chelsea Mayoh, Toby N. Trahair, Philip Crowe, Antoinette Anazodo, David S. Ziegler
Summary: The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is poor and surgical resection remains the main treatment option. Chemoradiation approaches have not significantly improved outcomes, while therapies targeting genomic drivers of MPNST have been unsuccessful. MEK inhibitors show promise in preclinical studies but clinical efficacy remains unknown.
NPJ PRECISION ONCOLOGY
(2021)
Article
Oncology
Inka Ristow, Frederic Madesta, Lennart Well, Farzad Y. Shenas, Felicia Wright, Isabel Molwitz, Said Farschtschi, Peter Bannas, Gerhard Adam, Victor F. Mautner, Rene Werner, Johannes Salamon
Summary: This study demonstrates that machine-learning classification using MRI-based radiomics features allows sensitive and specific differentiation of benign peripheral nerve sheath tumors (BPNST) and malignant peripheral nerve sheath tumors (MPNST) in patients with neurofibromatosis type 1 (NF1). The feature expression of premalignant atypical tumors (ANF) falls between that of benign and malignant tumors, suggesting the biological plausibility of these radiomics features.
Review
Biochemistry & Molecular Biology
Teddy Mohamad, Camille Plante, Jean-Philippe Brosseau
Summary: This review article summarizes the natural history of malignant peripheral nerve sheath tumors (MPNSTs), discusses mouse models representing the progression to MPNST, explores the role of the tumor microenvironment in MPNST development, and examines the signaling pathways associated with MPNST development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ziyu Guo, Wei Liu, Ziqian Dong, Lan Yang, Peng Xie
Summary: This is a rare case of malignant peripheral nerve sheath tumor involving the solitary lumbar vertebra. The patient presented with growing lumbocrural pain for 2 months. CT scan revealed a solitary vertebral lesion, highly suggestive of metastatic malignancy. F-18-FDG PET/CT showed heterogeneous intense FDG accumulation in the vertebral lesion with an SUVmax of 16.4. Pathological examination confirmed the diagnosis of malignant peripheral nerve sheath tumor. This case highlights the importance of considering MPNST when there is solitary vertebra invasion with increased FDG uptake.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Medicine, General & Internal
Kyung Jong Kim, Min Sung Kim, Ran Hong, Sung-Chul Lim
Summary: This article presents a case study of a 62-year-old female patient with neurofibromatosis, gastrointestinal stromal tumor, and angiomyolipoma. The patient underwent surgery and radiation therapy, resulting in improved symptoms and no relapse.
Article
Oncology
Mandara M. Harikar, Gianluca Ferini, Paolo Palmisciano, Muhammad Shakir, Paolo Amico, Stefano Ferraresi, Giuseppe E. Umana
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas that originate from mesenchymal tissue. The case report describes a patient with MPNST in the forearm who underwent microsurgery followed by image-guided radiation therapy, resulting in complete tumor disappearance at the 18-month follow-up.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Ajmain Chowdhury, Juan Vivanco-Suarez, Nahom Teferi, Alex Belzer, Hend Al-Kaylani, Meron Challa, Sarah Lee, John M. Buatti, Patrick Hitchon
Summary: Primary craniospinal MPNSTs are rare and have an aggressive clinical course. Early diagnosis and treatment are essential for managing these tumors. Maximal resection, low-grade pathology, young age (<30), and adjuvant radiotherapy were associated with improved survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Otorhinolaryngology
Raven Dunn, Matthew J. Marget, Suhael Momin, Laura Garcia-Rodriguez
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare and aggressive subtype of sarcomas with neural origin. Head and neck manifestations are uncommon, presenting challenges in diagnosis and management. However, achieving local control with good aesthetic outcome can be possible through excision and radiation therapy.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Pediatrics
Samantha W. E. Knight, Tristan E. Knight, Teresa Santiago, Andrew J. Murphy, Abdelhafeez H. Abdelhafeez
Summary: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with nerve sheath differentiation. They have a tendency to metastasize and are relatively common in individuals with neurofibromatosis type 1. The staging of MPNSTs is complex and requires multi-disciplinary collaboration. Surgical management is the primary approach, with non-surgical modalities playing a supportive role. Advances in molecular characterization have allowed the integration of targeted inhibitors into MPNST management.
Article
Clinical Neurology
Michael Zhang, Elizabeth Tong, Forrest Hamrick, Edward H. Lee, Lydia T. Tam, Courtney Pendleton, Brandon W. Smith, Nicholas F. Hug, Sandip Biswal, Jayne Seekins, Sarah A. Mattonen, Sandy Napel, Cynthia J. Campen, Robert J. Spinner, Kristen W. Yeom, Thomas J. Wilson, Mark A. Mahan
Summary: This study developed a machine learning approach using high-dimensional radiomics features and clinical data to differentiate benign from malignant peripheral nerve sheath tumors (PNSTs). The method achieved high specificity and AUC on the test set, outperforming human experts in tumor classification.
Article
Oncology
Mohit R. Sharma, Ketul Sureshbhai Puj, Abhijeet A. Salunke, Shashank J. Pandya, Jahnavi S. Gandhi, Ankita R. Parikh
Summary: The study analyzed prognostic factors and treatment outcomes of 92 patients with MPNST, finding that the presence of NF1, tumor grade, and margin status were closely related to patient survival. For patients receiving curative-intent treatment, tumor grade and margin status significantly affected disease-free survival, while the presence of NF1 and tumor location had a significant impact on overall survival.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Review
Clinical Neurology
Ryuya Yamanaka, Azusa Hayano, Yasuo Takashima
NEUROSURGICAL REVIEW
(2019)
Article
Multidisciplinary Sciences
Yasuo Takashima, Atsushi Kawaguchi, Yasuo Iwadate, Hiroaki Hondoh, Junya Fukai, Koji Kajiwara, Azusa Hayano, Ryuya Yamanaka
Article
Oncology
Azusa Hayano, Yasuo Takashima, Ryuya Yamanaka
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Yasuo Takashima, Atsushi Kawaguchi, Azusa Hayano, Ryuya Yamanaka
Article
Multidisciplinary Sciences
Yasuo Takashima, Atsushi Kawaguchi, Ryuichi Sato, Kenichi Yoshida, Azusa Hayano, Jumpei Homma, Junya Fukai, Yasuo Iwadate, Koji Kajiwara, Shin Ishizawa, Hiroaki Hondoh, Masakazu Nakano, Seishi Ogawa, Kei Tashiro, Ryuya Yamanaka
SCIENTIFIC REPORTS
(2019)
Article
Oncology
Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka, Ryuya Yamanaka
Article
Cell Biology
Yasuo Takashima, Atsushi Kawaguchi, Ryuya Yamanaka
Article
Oncology
Yasuo Takashima, Azusa Hayano, Ryuya Yamanaka
CLINICAL CANCER RESEARCH
(2020)
Article
Multidisciplinary Sciences
Yasuo Takashima, Atsushi Kawaguchi, Yasuo Lwadate, Hiroaki Hondoh, Junya Fukai, Koji Kajiwara, Azusa Hayano, Ryuya Yamanaka
Article
Multidisciplinary Sciences
Yasuo Takashima, Momoko Hamano, Junya Fukai, Yasuo Iwadate, Koji Kajiwara, Tsutomu Kobayashi, Hiroaki Hondoh, Ryuya Yamanaka
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Yasuo Takashima, Atsushi Kawaguchi, Junya Fukai, Yasuo Iwadate, Koji Kajiwara, Hiroaki Hondoh, Ryuya Yamanaka
Summary: Dysregulation of cell morphology and cell-cell interaction is crucial for cancer cell growth and metastasis. The balance between ECM and MMP plays a key role in cancer cell morphology and angiogenesis. Gene signatures associated with PCNSL morphology and microenvironment were identified through NGS, with prognostic prediction formulas developed and collagen genes found to contribute to microenvironment regulation. A combinatorial expression of representative genes enabled precise prognosis prediction and diagnosis of PCNSL cell types with MTX resistance.
Article
Oncology
Yasuo Takashima, Momoko Hamano, Kengo Yoshii, Azusa Hayano, Junya Fukai, Yasuo Iwadate, Koji Kajiwara, Hiroaki Hondoh, Ryuya Yamanaka
Summary: The study investigated expression modules reflecting the reciprocal expression of cancer microenvironment and immune response-related genes associated with poor prognosis in primary central nervous system lymphoma (PCNSL). Weighted gene coexpression network analysis revealed representative modules including neurogenesis, immune response, anti-virus, microenvironment, gene expression, and translation, extracellular matrix, morphogenesis, and cell adhesion. The results suggest that the differential expression and balance of immune response and microenvironment genes may play a crucial role in the growth and prognosis prediction of PCNSL tumors.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Yasuo Takashima, Atsushi Kawaguchi, Yasuo Iwadate, Hiroaki Hondoh, Junya Fukai, Koji Kajiwara, Azusa Hayano, Ryuya Yamanaka
Meeting Abstract
Oncology
Yasuo Takashima, Azusa Hayano, Ryuya Yamanaka
Article
Nursing
Saori Tamura, Koichi Sakaguchi, Ryuya Yamanaka
ASIA-PACIFIC JOURNAL OF ONCOLOGY NURSING
(2019)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
