Article
Endocrinology & Metabolism
Ning Ai Liu, Anat Ben-Shlomo, John D. Carmichael, Christina Wang, Ronald S. Swerdloff, Anthony P. Heaney, Garni Barkhoudarian, Daniel Kelly, Mazen Noureddin, Lin Lu, Manish Desai, Yana Stolyarov, Kevin Yuen, Adam N. Mamelak, James Mirocha, Mourad Tighiouart, Shlomo Melmed
Summary: Seliciclib may directly target pituitary corticotrophs in patients with Cushing's disease and reverse hypercortisolism. However, further research is needed regarding the liver toxicity associated with seliciclib.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biotechnology & Applied Microbiology
Yan Zhang, Danrong Wu, Ruoqiu Wang, Min Luo, Dong Wang, Kaiyue Wang, Yi Ai, Li Zheng, Qiao Zhang, Lixin Shi
Summary: This article reports a rare case of ectopic ACTH-secreting pituitary adenoma in the clival region. In addition to the more common organs, special attention should be paid to ectopic ACTH-secreting pituitary adenomas in the clivus region when diagnosing ectopic ACTH syndrome.
ONCOTARGETS AND THERAPY
(2022)
Article
Endocrinology & Metabolism
Dongyun Zhang, Robert Damoiseaux, Lilit Babayan, Everett Kanediel Rivera-Meza, Yingying Yang, Marvin Bergsneider, Marilene B. Wang, William H. Yong, Kathleen Kelly, Anthony P. Heaney
Summary: CUDC-907 has been identified as a potent inhibitor of both murine and human corticotroph tumor ACTH secretion and cell proliferation, showing promising efficacy in in vitro and in vivo models of CD. Its mechanism of action involves HDAC1/2 inhibition at the transcriptional level combined with PI3K-mediated inhibition of corticotroph cell viability to reduce ACTH secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Mina M. Gerges, Kavelin Rumalla, Saniya S. Godil, Iyan Younus, Walid Elshamy, Georgiana A. Dobri, Ashutosh Kacker, Abtin Tabaee, Viay K. Anand, Theodore H. Schwartz
Summary: Following gross total resection of nonfunctioning pituitary adenomas, the 10-year chance of recurrence is low and the need for treatment even lower. After subtotal resection, upfront radiation therapy may prevent progression, but even without it, the need for intervention at 10 years is only approximately 20%, warranting a period of observation to prevent unnecessary prophylactic radiation therapy. Tumor volume > 1 cm(3), Knosp score >= 3, and Ki-67 >= 3% may prompt closer follow-up or justify early prophylactic radiation therapy.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed
Summary: A novel regulatory region near the intron 2/exon 3 junction in the human POMC gene functions as a second promoter and enhancer, regulated by methylation status in ACTH-secreting pituitary tumors, and potentially influencing the clinical phenotype of Cushing disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Takako Araki, Yukiko Tone, Masaaki Yamamoto, Hiraku Kameda, Anat Ben-Shlomo, Shozo Yamada, Akira Takeshita, Masato Yamamoto, Yasuhiko Kawakami, Masahide Tone, Shlomo Melmed
Summary: We identified a novel regulatory region near the intron 2/exon 3 junction in the POMC gene, serving as a second promoter and enhancer regulated by methylation status, with demethylation patterns correlating with Cushing disease clinical phenotypes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Meleine Landry Konan, Aderehime Haidara, Wilfried M. Meuga, Grace Djonde, Sidoine M. Gbazi, Marcel Okamon, Louis K. Derou, Dominique Ndri Oka
Summary: This study assessed the early results of EEA for pituitary adenoma in an under-equipped environment, showing a relatively high rate of postoperative complications. However, improvements in the technique of local surgeons could lead to better patient outcomes.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Siyuan Yu, Mohammad Taghvaei, Sarah Collopy, Keenan Piper, Michael Karsy, Pascal Lavergne, Blair Barton, Chandala Chitguppi, Glen D'Souza, Marc R. Rosen, Gurston G. Nyquist, Mindy Rabinowitz, Christopher J. Farrell, James J. Evans
Summary: This study demonstrated that discharge on postoperative day 1 after endonasal transsphenoidal surgery (ETS) for pituitary adenomas was safe and feasible without an increased risk of readmission within 30 days. Factors associated with increased risk of prolonged length of stay included diabetes insipidus (DI) and intraoperative cerebrospinal fluid leak, while the surgical epoch was associated with decreased risk of prolonged length of stay.
JOURNAL OF NEUROSURGERY
(2022)
Review
Endocrinology & Metabolism
Elzbieta Moszczynska, Elzbieta Marczak, Mieczyslaw Szalecki, Krzysztof Kadziolka, Marcin Roszkowski, Patrycja Zagata-Lesnicka
Summary: This study analyzed the diagnostic accuracy of BIPSS in pediatric patients with CD, showing that BIPSS has high accuracy in identifying the underlying cause and guiding surgical intervention, but limited value in tumor localization.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Juan Manuel Canelo Moreno, Elena Dios Fuentes, Eva Venegas Moreno, Pablo Jesus Remon Ruiz, Cristina Munoz Gomez, Ana Pinar Gutierrez, Eugenio Cardenas Valdepenas, Ariel Kaen, Alfonso Soto Moreno
Summary: This study aimed to investigate the prevalence and predictive factors of water and electrolyte disturbances in patients undergoing surgery with an extended endoscopic endonasal approach. The study found a high prevalence of electrolyte disturbances, with most cases being transient hypotonic polyuria and a smaller proportion being transient or permanent diabetes insipidus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Yuanzhi Xu, Maximiliano Alberto Nunez, Ahmed Mohyeldin, Vera Vigo, Ying Mao, Aaron A. Cohen-Gadol, Juan C. Fernandez-Miranda
Summary: This study provides a detailed anatomical description of the dorsal clinoidal space (DCS) from endoscopic endonasal and transcranial perspectives. The study identified the shape, dimensions, and boundaries of the DCS, as well as potential routes for tumor invasion from the cavernous sinus. The findings may help improve surgical outcomes in the treatment of invasive pituitary adenomas and other parasellar lesions.
JOURNAL OF NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Review
Endocrinology & Metabolism
Dimin Zhu, Zongming Wang, Tian Tian, Xinyi Wu, Dongsheng He, Yonghong Zhu, Dawei Liu, Haijun Wang
Summary: Crooke's cell adenoma is a tumor subtype with obvious clinical aggressive behavior. Male patients are more common and often present with elevated adrenocorticotropic hormone levels. The tumor diameter is larger and invasive. Female patients dominate the reported cases and exhibit symptoms such as Cushing's syndrome and hormonal dysfunction. Tumors are more commonly macroadenomas and grow in the suprasellar region, with a high recurrence rate and a significant proportion progressing to pituitary carcinomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Emrah Celtikci, Muammer Melih Sahin, Mustafa Caglar Sahin, Emetullah Cindil, Zuhal Demirtas, Hakan Emmez
Summary: This retrospective study aimed to determine the necessity of intraoperative MRI scans following endoscopic endonasal pituitary adenoma surgery. The results show that for adenomas limited in the sellae and not invading the cavernous sinus, an IO-MRI scan is not necessary, but it is strongly recommended if there is any suprasellar and parasellar extension and/or cavernous sinus invasion.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Dongyun Zhang, Willy Hugo, Peter Redublo, Hui Miao, Marvin Bergsneider, Marilene B. Wang, Won Kim, William H. Yong, Anthony P. Heaney
Summary: This study identified cell populations in human corticotroph tumors using single-cell RNA sequencing and successfully developed sustained ACTH-secreting human corticotroph tumoroid cultures through modifications in in vitro culture methods, which will contribute to further translational research for identifying therapies for Cushing disease.
Article
Clinical Neurology
Brandon A. Sherrod, Robert Kim, Joshua Hunsaker, Courtney Rada, Clint Christensen, Gregory J. Stoddard, Darrel Brodke, Mark A. Mahan, Marcus D. Mazur, Erica F. Bisson, Andrew T. Dailey
Summary: This study analyzed whether total intravenous anesthesia (TIVA) is associated with a greater risk of postoperative ileus (PI) compared to inhaled anesthetic during thoracolumbar posterior spinal fusion (PSF) surgery. The results showed that TIVA patients had a higher rate of PI compared to inhalation-only patients, which may be attributed to increased intraoperative opiate use.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Clinical Neurology
Brandon A. Sherrod, Giorgos D. Michalopoulos, Graham Mulvaney, Nitin Agarwal, Andrew K. Chan, Anthony L. Asher, Domagoj Coric, Michael S. Virk, Kai -Ming Fu, Kevin T. Foley, Paul Park, Cheerag D. Upadhyaya, John J. Knightly, Mark E. Shaffrey, Eric A. Potts, Christopher I. Shaffrey, Oren N. Gottfried, Khoi D. Than, Michael Y. Wang, Luis M. Tumialan, Dean Chou, Praveen V. Mummaneni, Mohamad Bydon, Erica F. Bisson
Summary: This study aimed to elucidate patient and surgical factors associated with new-onset sustained pain after surgery for cervical spondylotic myelopathy (CSM). By reviewing data from the Quality Outcomes Database (QOD) CSM module, the authors found that increased baseline Neck Disability Index (NDI), number of levels treated surgically, and duration of symptoms longer than 3 months preoperatively were positively correlated with the risk of new-onset neck pain following CSM surgery.
JOURNAL OF NEUROSURGERY-SPINE
(2023)
Article
Clinical Neurology
Jacob K. Greenberg, Madelyn R. Frumkin, Saad Javeed, Justin K. Zhang, Ruixuan Dai, Camilo A. Molina, Brenton H. Pennicooke, Nitin Agarwal, Paul Santiago, Matthew L. Goodwin, Deeptee Jain, Nicholas Pallotta, Munish C. Gupta, Jacob M. Buchowski, Eric C. Leuthardt, Zoher Ghogawala, Michael P. Kelly, Bruce L. Hall, Jay F. Piccirillo, Chenyang Lu, Thomas L. Rodebaugh, Wilson Z. Ray
Summary: This study evaluated the feasibility and acceptability of a multimodal preoperative mHealth assessment in patients with degenerative spine disease. The results showed that participants had high acceptability for this method and the data collected may provide new insights for patient selection and treatment guidance.
Article
Clinical Neurology
Vijay Letchuman, Liangliang He, Praveen V. Mummaneni, Nitin Agarwal, Liam J. Campbell, Saman Shabani, Andrew K. Chan, Christopher R. Abrecht, Catherine Miller, Sujatha Sankaran, Aksharananda Rambachan, Rhiannon Croci, Sigurd H. Berven, Dean Chou, Langston T. Holly, Zhonghui Guan
Summary: In this retrospective observational study, it was found that White patients had higher opioid usage than Black and Asian patients in both the inpatient and outpatient postoperative periods. This study highlights the impact of race on postoperative pain management and underscores the need for increased physician awareness of racial disparities to ensure unbiased opioid prescribing practices.
Article
Clinical Neurology
Andrew K. Chan, Mohamad Bydon, Erica F. Bisson, Steven D. Glassman, Kevin T. Foley, Christopher Shaffrey, Eric A. Potts, Mark E. Shaffrey, Domagoj Coric, John J. Knightly, Paul Park, Michael Y. Wang, Kai-Ming Fu, Jonathan R. Slotkin, Anthony L. Asher, Michael S. Virk, Giorgos D. Michalopoulos, Jian Guan, Regis W. Haid, Nitin Agarwal, Christine Park, Dean Chou, Praveen Mummaneni
Summary: This study compares the long-term outcomes of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) and traditional open TLIF for grade I degenerative lumbar spondylolisthesis. The results show no significant difference in disability, pain level, quality of life, or satisfaction between the two procedures at 60 months postoperatively.
NEUROSURGICAL FOCUS
(2023)
Article
Clinical Neurology
Saad Javeed, Jacob K. Greenberg, Benjamin Plog, Justin K. Zhang, Alexander T. Yahanda, Christopher F. Dibble, Jawad M. Khalifeh, Miguel Ruiz-Cardozo, Raj S. Lavadi, Camilo A. Molina, Paul Santiago, Nitin Agarwal, Brenton H. Pennicooke, Wilson Z. Ray
Summary: This study aims to establish clinical benchmarks for upper limb functional improvement following cervical spine surgery, including the minimal clinically important difference (MCID) and substantial clinical benefit (SCB). The results showed that the MCID of DASH score was -8 points and the SCB was -18 points, which can be used to evaluate minimal and significant improvement in upper limb function in patients undergoing cervical spine surgery.
Article
Clinical Neurology
Arjun Gupta, Vamsi Reddy, Awinita Barpujari, Raj Swaroop Lavadi, Prateek Agarwal, Yue-Fang Chang, James Mooney, Galal A. Elsayed, Nitin Agarwal
Summary: Neurosurgical subspecialty fellowship training has become increasingly popular among young neurosurgeons, often in multiple subspecialties. This study provides a detailed analysis of subspecialty fellowship training completion trends and demographics among U.S. academic neurosurgeons.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Alex G. Raman, Neil Parikh, Radhika Gupta, Raj Swaroop Lavadi, Raghav Gupta, Robert F. Heary, Kristopher Kimmell, Justin Singer, Nitin Agarwal
Summary: This study investigated the extent of pain experienced by neurosurgeons and the impact of ergonomics training on pain. The results showed that neurosurgeons commonly suffer from pain and that ergonomics training does not significantly alleviate it. This suggests a need for optimizing ergonomics education to achieve observable benefits.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Avi A. Gajjar, Anthony Huy Dinh Le, Raj Swaroop Lavadi, Ujwal Boddeti, Awinita Barpujari, Hussam Abou-Al-Shaar, Nitin Agarwal
Summary: The use of robotics in spinal surgery has great potential and has seen continuous growth since 1985. There are numerous devices approved by the FDA for spinal operations. Robotic surgery offers improved patient outcomes compared to conventional methods, with superior spatial resolution, geometric accuracy, and faster implant placement. This review discusses the design process, development stages, and the most commonly used FDA-approved robots in spinal surgery.
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2023)
Article
Clinical Neurology
Saman Shabani, Nitin Agarwal, Alma Rechav Ben-Natan, Jeremy Huang, Vivian P. Le, Dean Chou, Praveen V. Mummaneni
OPERATIVE NEUROSURGERY
(2023)
Article
Clinical Neurology
Nitin Agarwal, Souvik Roy, Raj Swaroop Lavadi, Kevin P. Patel, Alp Ozpinar, Nima Alan, Thomas J. Buell, D. Kojo Hamilton
Summary: This study successfully managed severe angular chin-on-chest deformity through a single midline incision and periosteal dissection. The sagittal and coronal corrections were achieved by placing multiple screws, performing posterior osteotomies and interlaminar decompressions, and using a third titanium rod for construct augmentation. The patient showed durable correction and continued satisfaction with the operation on long-term follow-up.
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Meeting Abstract
Clinical Neurology
Andrew K. Chan, Vijay Letchuman, Praveen V. Mummaneni, John Frederick Burke, Nitin Agarwal, Erica Fay Randy Bisson, Mohamad Bydon, Kevin T. Foley, Christopher I. Shaffrey, Steven D. Glassman, Michael Y. Wang, Paul Park, Eric A. Potts, Mark Edwin Shaffrey, Domagoj Coric, John J. Knightly, Kai-Ming G. Fu, Jonathan Slotkin, Anthony L. Asher, Michael S. Virk, Panagiotis Kerezoudis, Mohammed Alvi, Jian Guan, Regis W. Haid, Anthony Michael DiGiorgio
Article
Otorhinolaryngology
Galal A. Elsayed, Raj Swaroop Lavadi, Sangami Pugazenthi, Vinay Jaikumar, Rida Mitha, Daniel M. Hafez, John O. Ogunlade, Nitin Agarwal
Summary: Spatial computing in a surgical context allows for reconstructed four-dimensional models of radiological imaging, providing more insight into personalized surgical approaches. Spine surgery has particularly benefited from perioperative assessment using spatial computing. This article describes the use of spatial computing to perform a perioperative assessment for a revision spinal deformity surgery.
JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE
(2023)
Review
Otorhinolaryngology
Paulomi Gohel, Kevin P. Patel, Raj Swaroop Lavadi, Daryl P. Fields, Nitin Agarwal, Nima Alan
Summary: This article conducted an advanced bibliometric analysis to compile the top ten most-cited articles on the topic of lateral anterior column release (ACR). The findings revealed that lateral ACR has been the subject of significant scholarly attention since its advent, and further high-level analyses and long-term follow-up studies are necessary to improve our understanding of this approach.
JOURNAL OF CRANIOVERTEBRAL JUNCTION AND SPINE
(2023)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)