Article
Immunology
James S. Griffiths, P. Lewis White, Magdalena A. Czubala, Elena Simonazzi, Mariolina Bruno, Aiysha Thompson, Pierre J. Rizkallah, Mark Gurney, Diogo M. da Fonseca, Julian R. Naglik, Wendy Ingram, Keith Wilson, Frank L. van de Veerdonk, Rosemary Barnes, Philip R. Taylor, Selinda J. Orr
Summary: An immunocompromised patient was found to have a homozygous deletion mutation in the Dectin-2 receptor, resulting in a dysfunctional form of the receptor and an inability to mount a cytokine response to Aspergillus fumigatus. This first identified Dectin-2-deficient patient died of complications of invasive aspergillosis.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Castrejon-Jimenez Nayeli Shantal, Castillo-Cruz Juan, Baltierra-Uribe Shantal Lizbeth, Hernandez-Gonzalez Juan Carlos, Garcia-Perez Blanca Estela
Summary: This review discusses the virulence factors, immune response evasion strategies, and intracellular behavior of Candida glabrata. By comparing it with Mycobacterium tuberculosis, the review highlights the successful pathogenicity of C. glabrata in manipulating the immune response.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Microbiology
Maryam Roudbary, Sunil Kumar, Awanish Kumar, Lucia Cernakova, Fatemeh Nikoomanesh, Celia F. Rodrigues
Summary: Patients with severe COVID-19, especially those in intensive care units, are highly susceptible to fungal co-infections, which can lead to severe illness and death. Timely diagnosis and treatment of fungal co-infections are crucial in preventing adverse outcomes.
Review
Microbiology
James S. Griffiths, Giorgio Camilli, Natalia K. Kotowicz, Jemima Ho, Jonathan P. Richardson, Julian R. Naglik
Summary: Fungal pathogens cause significant mortality and disease burden worldwide, with IL-1 family cytokines playing crucial roles in different fungal infections, although mechanisms vary.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Simon D. P. Baugh, Anna Chaly, Damian G. Weaver, Jeffrey C. Pelletier, Sandeep Thanna, Katie B. Freeman, Allen B. Reitz, Richard W. Scott
Summary: The research team has developed a series of non-peptide antifungal analogs through chemical optimization, resulting in highly potent, broad-spectrum compounds with low mammalian cell cytotoxicity. These compounds have the potential to become new antifungal agents.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Infectious Diseases
Susana Ruiz Mendoza, Susie Coutinho Liedke, Claudia Rodriguez de La Noval, Marina da Silva Ferreira, Kamilla Xavier Gomes, Leandro Honorato, Leonardo Nimrichter, Jose Mauro Peralta, Allan Jefferson Guimaraes
Summary: Fungal infections are on the rise, requiring new and efficient treatment options. Passive immunizations targeting fungal cells with specific antibody structures could potentially play a role in early interventions.
Article
Microbiology
Sanne Schrevens, Dominique Sanglard
Summary: Urinary tract infections caused by fungi, especially Candida species, are common in patients with urinary catheters, and can lead to high mortality rates. The pathogenesis of Candida glabrata UTIs has not been extensively studied, and bioluminescence imaging is an effective tool for in vivo research in this area.
Article
Microbiology
Yazhou Wang, Madeleine Spatz, Gregory Da Costa, Chloe Michaudel, Alexia Lapiere, Camille Danne, Allison Agus, Marie-Laure Michel, Mihai G. Netea, Philippe Langella, Harry Sokol, Mathias L. Richard
Summary: This study found that double deletion of Dectin-1 and Dectin-2 receptors provides protection against gut inflammation, mainly through modulation of the gut microbiota. Bacteria from the Lachnospiraceae family seem to play a central role in this protective effect.
Article
Biochemistry & Molecular Biology
Yanan Zhu, Tao Shi, Xia Lu, Zhen Xu, Junxing Qu, Zhiyong Zhang, Guoping Shi, Sunan Shen, Yayi Hou, Yugen Chen, Tingting Wang
Summary: Mice lacking Dectin-3 showed increased tumorigenesis and Candida albicans burden, leading to enhanced IL-22 production in innate lymphoid cells, highlighting the significance of commensal fungi in regulating host immunity and promoting tumorigenesis.
Article
Cell Biology
David B. Sykes, Michelle M. Martinelli, Paige Negoro, Shuying Xu, Katrina Maxcy, Kyle Timmer, Adam L. Viens, Natalie J. Alexander, Johnny Atallah, Brendan D. Snarr, Shane R. Baistrocchi, Natalie J. Atallah, Alex Hopke, Allison Scherer, Ivy Rosales, Daniel Irimia, Donald C. Sheppard, Michael K. Mansour
Summary: Research has shown that using conditionally immortalized murine neutrophil progenitors can generate a large number of homogeneous granulocyte-macrophage progenitors (GMPs) which have potential therapeutic effects for treating candidemia and pulmonary aspergillosis. Transfused GMPs can differentiate into mature neutrophils in the bone marrow and spleen, and exhibit appropriate responses to inflammatory stimuli. Transfusions of conditionally immortalized GMPs can significantly improve survival rates in models of candidemia and pulmonary aspergillosis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Microbiology
Aiysha Thompson, Diogo M. da Fonseca, Louise Walker, James S. Griffiths, Philip R. Taylor, Neil A. R. Gow, Selinda J. Orr
Summary: Invasive Candida infections are mainly caused by four Candida species, and C-type lectin-like receptors (CLRs) are involved in the immune responses to these infections. Different Candida species have varying mannan contents in their cell walls, and Mincle and Dectin-2 play important roles in regulating cytokine production and clearance of these infections during systemic infection. Dependence on mannan-detecting CLRs varies between different Candida species during systemic infection.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biophysics
Eduardo U. Anaya, Akram Etemadi Amin, Michael J. Wester, Michael E. Danielson, Kyle S. Michel, Aaron K. Neumann
Summary: Dectin-1A recognizes the structural component of Candida species cell walls, 5-(1,3;1,6)-glucan, and its ability to induce signaling depends on the degree of its structure. Stimulation with glucan leads to aggregation of Dectin-1A, while it remains in a low aggregation state in resting cells. The degree of glucan structure also affects the molecular aggregation of Dectin-1A at fungal particle contact sites.
BIOPHYSICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Thomas Senoner, Robert Breitkopf, Benedikt Treml, Sasa Rajsic
Summary: Invasive fungal infections are a major challenge in organ transplant patients, with candidiasis being the most common, followed by aspergillosis and cryptococcosis. Liver transplant recipients are at high risk for candidiasis and aspergillosis, and targeted prophylaxis is recommended. Timely treatment is crucial for optimal outcomes in transplanted patients. This article provides an overview of the epidemiology, risk factors, prophylaxis, and treatment strategies for the most common fungal infections in organ transplantation, focusing on liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Pablo Mata-Martinez, Marta Bergon-Gutierrez, Carlos del Fresno
Summary: Dectin-1, a C-type lectin receptor, plays a crucial role in antifungal responses and immune memory. It recognizes various ligands and triggers different immune reactions. However, the underlying mechanisms of its involvement in trained immunity are not fully understood.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Fatma Zohra Aissat, David W. Denning
Summary: Invasive and superficial fungal infections are increasingly reported in Algeria, indicating a rise in their occurrence due to increased risk factors and improved diagnostic means, particularly in university hospitals. However, hospitals in the interior of the country have lower diagnostic capabilities compared to the major cities in the north.
