Article
Medicine, General & Internal
Felix Teufel, Jacqueline A. Seiglie, Pascal Geldsetzer, Michaela Theilmann, Maja E. Marcus, Cara Ebert, William Andres Lopez Arboleda, Kokou Agoudavi, Glennis Andall-Brereton, Krishna K. Aryal, Brice Wilfried Bicaba, Garry Brian, Pascal Bovet, Maria Dorobantu, Mongal Singh Gurung, David Guwatudde, Corine Houehanou, Dismand Houinato, Jutta M. Adelin Jorgensen, Gibson B. Kagaruki, Khem B. Karki, Demetre Labadarios, Joao S. Martins, Mary T. Mayige, Roy Wong McClure, Joseph Kibachio Mwangi, Omar Mwalim, Bolormaa Norov, Sarah Crooks, Farshad Farzadfar, Sahar Saeedi Moghaddam, Bahendeka K. Silver, Lela Sturua, Chea Stanford Wesseh, Andrew C. Stokes, Utibe R. Essien, Jan-Walter De Neve, Rifat Atun, Justine I. Davies, Sebastian Vollmer, Till W. Barnighausen, Mohammed K. Ali, James B. Meigs, Deborah J. Wexler, Jennifer Manne-Goehler
Summary: The prevalence of overweight, obesity, and diabetes is increasing rapidly in low-income and middle-income countries, with BMI affecting the risk of diabetes, but there are significant regional variations in this association.
Article
Gastroenterology & Hepatology
Eun Hyo Jin, Kyungdo Han, Dong Ho Lee, Cheol Min Shin, Joo Hyun Lim, Yoon Jin Choi, Kichul Yoon
Summary: The study found that obesity and metabolic syndrome are associated with an increased risk of earlier-onset colorectal cancer, particularly left-sided colon cancer. Individuals with metabolic syndrome and obesity have a higher risk of developing colorectal cancer before the age of 50, highlighting the importance of preventive interventions for this population.
Article
Public, Environmental & Occupational Health
Chen Zhang, Weiwei Wang, Xiaotian Chang, Siyan Zhan, Shengfeng Wang, Lei Feng, Yongfeng Song
Summary: This cohort study examined the relationship between obesity and hearing loss among middle-aged and older adults. It found that central obesity was significantly associated with hearing loss, especially in males. Among males, the underweight group had the highest risk of hearing loss, while the obese groups had a lower risk compared to the normal weight group. Among females, only the overweight group had a lower risk of hearing loss than the normal weight group.
Article
Multidisciplinary Sciences
Kadari Cisse, Delwende Rene Severin Samadoulougou, Joel Dofinissery Bognini, Tiga David Kangoye, Fati Kirakoya-Samadoulougou
Summary: This study in Burkina Faso aimed to determine the prevalence of metabolic syndrome and its determinants among the adult population. The prevalence of metabolic syndrome varied according to different definitions, with higher rates among those living in urban areas and older individuals.
Article
Multidisciplinary Sciences
Yi-Hsuan Lin, Hsiao-Ting Chang, Yen-Han Tseng, Harn-Shen Chen, Shu-Chiung Chiang, Tzeng-Ji Chen, Shinn-Jang Hwang
Summary: This study aimed to investigate the situation of metabolically healthy overweight and obesity (MHOO) individuals in Asia and the factors associated with maintaining their metabolic health. The results showed that older age, longer follow-up time, higher BMI, and increased waist circumference were detrimental factors for metabolic health. However, sociodemographic factors and lifestyle factors did not have significant relationships with metabolic health among MHOO individuals.
Article
Cardiac & Cardiovascular Systems
Man Li, Ping Zhu, Shu-xia Wang
Summary: Patients with high WC and diabetes have an increased risk of cardiovascular death. WC and diabetes may provide additional prognostic value beyond traditional risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Klarissa R. Wilkinson, Larry A. Tucker, Lance E. Davidson, Bruce W. Bailey
Summary: Regular consumption of non-fat milk was associated with lower levels of abdominal adiposity, while no significant differences were found for full-fat milk drinkers or milk abstainers.
Article
Cardiac & Cardiovascular Systems
Edward Franek, Prem Pais, Jan Basile, Claudia Nicolay, Sohini Raha, Ana Hickey, Nadia. N. N. Ahmad, Manige Konig, Hong Kan, Hertzel. C. C. Gerstein
Summary: In this post hoc analysis, researchers analyzed data from 4952 patients with type 2 diabetes and found that waist-to-hip ratio, waist circumference, and waist circumference adjusted for hip circumference were independent risk factors for cardiovascular disease outcomes. However, body mass index was only a risk factor for heart failure requiring hospitalization. These findings indicate the importance of considering body fat distribution when assessing cardiovascular risk.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Multidisciplinary Sciences
Fernanda Muniz de Macedo Stumpf, Alessandra Silva Dias de Oliveira, Eduardo Faerstein, Cintia Chaves Curioni
Summary: This study investigated the association between BMI and waist circumference with multimorbidity, and identified patterns of multimorbidity. The results showed that an increase in both BMI and waist circumference was associated with a higher number of morbidities and specific patterns of diseases.
Article
Endocrinology & Metabolism
Sangmo Hong, Jung Hwan Park, Kyungdo Han, Chang Beom Lee, Dong Sun Kim, Sung Hoon Yu
Summary: Elderly patients with T2DM and obesity have better clinical outcomes compared to normal-weight patients. Waist circumference (WC) is a suitable indicator for assessing obesity-related risks in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Huiru Jiang, Yongfu Yu, Leah Li, Wanghong Xu
Summary: The study found evidence for a weak effect of fetal exposure to famine on body measurements in adulthood. It also suggests the importance of considering other factors such as age and gender when evaluating the impact of early life famine exposure on adult obesity.
Article
Nutrition & Dietetics
Jose Ignacio Ramirez-Manent, Andres Martinez Jover, Caroline Silveira Martinez, Pilar Tomas-Gil, Pau Marti-Lliteras, Angel Arturo Lopez-Gonzalez
Summary: Metabolic syndrome (Met-S) is a significant health problem associated with insulin resistance (IR). This study aims to assess the relationship between different insulin resistance risk scales and Met-S and identify the components of Met-S that contribute most to IR. The results demonstrate that insulin resistance risk scales can accurately classify individuals with Met-S, particularly when using the International Diabetes Federation (IDF) criteria, and waist circumference is the key factor associated with both IR and Met-S.
Article
Biochemistry & Molecular Biology
Yu-Lin Shih, Chin-Chuan Shih, Tzu-Cheng Huang, Jau-Yuan Chen
Summary: This study investigated the relationship between homocysteine levels and metabolic syndrome. The results showed that the metabolic syndrome group had higher homocysteine levels, and participants with higher homocysteine levels were more likely to have metabolic syndrome.
Article
Multidisciplinary Sciences
Bum Ju Lee, Mi Hong Yim
Summary: Both anthropometric and body composition indices are associated with metabolic risk factors, but anthropometric indices such as waist-to-height ratio and waist circumference are generally better predictors for certain risk factors, particularly in men for hypertension and hyperlipidemia with regards to waist-to-height ratio, and in women for diabetes and hypo-HDL cholesterolemia with regards to waist circumference.
SCIENTIFIC REPORTS
(2021)
Article
Psychiatry
Lara Onofre Ferriani, Daniela Alves Silva, Maria del Carmen Bisi Molina, Jose Geraldo Mill, Andre Russowsky Brunoni, Maria de Jesus Mendes da Fonseca, Arlinda B. Moreno, Isabela M. Bensenor, Odaleia Barbosa de Aguiar, Sandhi Maria Barreto, Maria Carmen Viana
Summary: This study aimed to assess the association between depression and Metabolic Syndrome (MetS). The results showed that baseline depression was positively associated with recovered, incident, and persistent MetS. Baseline depression was also associated with specific components of MetS at follow-up, such as large waist circumference, high triglycerides, low high-density lipoprotein cholesterol, and hyperglycemia. The presence of three or more MetS components at follow-up was strongly associated with baseline depression. These findings suggest that depression is a risk factor for the development of MetS and emphasize the importance of monitoring metabolic and cardiovascular alterations in individuals with depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Kineret Mazor-Aronovitch, Orit Pinhas-Hamiel, Dikla Pivko-Levy, Dalit Modan-Moses, Noa Levek, Shahar Miller, Michal Yackobovitch-Gavan, Noah Gruber, Michal Ben-Ami, Eve Stern, Tal Ben-Ari, Chana Graf-Barel, Rachel Frumkin Ben-David, Yael Levy-Shraga, Zohar Landau
Summary: Youth with a dual diagnosis of type 1 diabetes mellitus (T1DM) and attention-deficit/hyperactivity disorder (ADHD) have poorer glycemic control, especially in the context of untreated ADHD. Health-related quality of life does not differ between the control group, the treated ADHD group, and the untreated ADHD group.
PEDIATRIC DIABETES
(2021)
Article
Clinical Neurology
Aya Bardugo, Boris Fishman, Carmit Libruder, David Tanne, Amit Ram, Yael Hershkovitz, Inbar Zucker, Ariel Furer, Roy Gilon, Gabriel Chodick, Shmuel Tiosano, Estela Derazne, Dorit Tzur, Arnon Afek, Orit Pinhas-Hamiel, Cole Daniel Bendor, Gal Yaniv, Ran Shmuel Rotem, Gilad Twig
Summary: The study found an association between adolescent obesity and stroke in young adults, particularly with ischemic stroke, while the correlation with hemorrhagic stroke was weaker. The increasing prevalence of adolescent obesity may contribute to the future burden of stroke in young adults.
Article
Medicine, General & Internal
Moran Livne-Margolin, Itay Tokatly Latzer, Orit Pinhas-Hamiel, Gil Harari, Anat Achiron
Summary: The study found that the disability level in individuals with MS was not correlated with disease duration, lifestyle habits, or overweight/obesity, but was associated with central obesity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Aya Bardugo, Estela Derazne, Inbar Zucker, Cole D. Bendor, Gal Puris, Miri Lutski, Orit Pinhas-Hamiel, Tali Cukierman-Yaffe, Ofri Mosenzon, Meir Schechter, Dorit Tzur, Arnon Afek, Amir Tirosh, Hertzel C. Gerstein, Itamar Raz, Gilad Twig
Summary: Thyroid disorders diagnosed in adolescence are significantly associated with an increased risk of early-onset type 2 diabetes in both men and women, regardless of other health conditions and types of thyroid disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Noah Gruber, Moran Rathaus, Idit Ron, Rinat Livne, Sharon Sheinvald, Ehud Barhod, Rina Hemi, Amit Tirosh, Orit Pinhas-Hamiel, Amir Tirosh
Summary: FABP4 levels are associated with the diagnosis of DKA, with a significant decrease observed following insulin therapy, showing a certain sensitivity and specificity for the diagnosis of DKA.
Article
Endocrinology & Metabolism
Orit Pinhas-Hamiel, Aya Bardugo, Brian Reichman, Estela Derazne, Zohar Landau, Itay Tokatly Latzer, Liat Lerner-Geva, Jacob Rotschield, Dorit Tzur, Danny Ben-Zvi, Arnon Afek, Gilad Twig
Summary: A study showed that adolescents with severe and mild ADHD are at increased risk for obesity compared to those without ADHD, with higher prevalence of obesity among those with severe ADHD. The elevated risk persists in both males and females, indicating a strong association between ADHD and obesity in adolescents.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Noah Gruber, Lilach Marom Haham, Hila Raanani, Yoram Cohen, Lidia Gabis, Michal Berkenstadt, Liat Ries-Levavi, Shai Elizur, Orit Pinhas-Hamiel
Summary: Women with fragile X premutation (FXPC) have an increased metabolic risk, particularly in terms of waist circumference, glucose, and lipid levels. Metabolic screening is recommended for all women with FMR1 premutation to prevent cardiovascular comorbidities.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Shira Goldman, Orit Pinhas-Hamiel, Adi Weinberg, Adi Auerbach, Alina German, Alon Haim, Amnon Zung, Avivit Brener, David Strich, Erez Azoulay, Floris Levy-Khademi, Hanna Ludar, Ilana Koren, Marianna Rachmiel, Michal Yackobovitch-Gavan, Nehama Zuckerman-Levin, Odeya David, Rana Halloun, Ranit Cahn, Tal Ben-Ari, Yonatan Yeshayahu, Zohar Landau, Moshe Phillip, Yael Lebenthal
Summary: During the COVID-19 pandemic, there was a significant increase in the incidence of DKA in children with type 1 diabetes at diagnosis, particularly among children aged 6-11 years. This highlights the need for targeted measures to raise awareness among the public and healthcare providers.
PEDIATRIC DIABETES
(2022)
Review
Endocrinology & Metabolism
Noah Gruber, Orit Pinhas-Hamiel
Summary: This review provides an update on genetic disorders that cause diabetes and are associated with impaired hearing or vision. It compares these disorders and discusses potential mechanisms and novel treatments.
CURRENT DIABETES REPORTS
(2022)
Review
Endocrinology & Metabolism
Amy S. Shah, Philip S. Zeitler, Jencia Wong, Alexia S. Pena, Brandy Wicklow, Silva Arslanian, Nancy Chang, Junfen Fu, Preeti Dabadghao, Orit Pinhas-Hamiel, Tatsuhiko Urakami, Maria E. Craig
Summary: This chapter provides an overview of risk factors, diagnosis, and management strategies for youth-onset type 2 diabetes, including addressing co-morbidities and complications. It includes updates from recent studies and clinical trials, as well as information on approved pharmacologic therapies. The chapter also discusses the impact of social determinants of health and the challenges of managing care during the COVID-19 pandemic.
PEDIATRIC DIABETES
(2022)
Letter
Endocrinology & Metabolism
Noah Levek, Ruba Faruge-Hadiga, Orit Pinhas-Hamiel
Article
Endocrinology & Metabolism
Maya Simchoni, Estela Derazne, Orit Pinhas-Hamiel, Tali Cukierman-Yaffe, Cole D. Bendor, Aya Bardugo, Gabriel Chodick, Dorit Tzur, Ronit Endevelt, Herzel C. Gerstein, Arnon Afek, Gilad Twig
Summary: The increased incidence of adolescent obesity may be associated with lower cognitive performance than expected potential. This study found that male adolescents with severe obesity had a higher proportion of low cognitive scores compared to their normal-weight counterparts. Similar findings were observed in females. This study suggests that obesity is associated with a lower cognitive performance and the inability to fully achieve cognitive potential.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Neriya Levran, Noah Levek, Bruria Sher, Elinor Mauda-Yitzhak, Noah Gruber, Arnon Afek, Efrat Monsonego-Ornan, Orit Pinhas-Hamiel
Summary: The Mediterranean diet intervention in youth with type 1 diabetes is feasible and leads to improvements in monounsaturated fat intake, time-in-range (TIR), and diastolic blood pressure.
Meeting Abstract
Endocrinology & Metabolism
Sadaf Farooqi, Jesus Argente, Gabriel Martos-Moreno, Elif Oral, Bessie Spiliotis, Eirini Kostopoulou, Orit Pinhas-Hamiel, Michal Ben-Ami, Olga Ohayon, Cecilia Scimia, Guojun Yuan, Murray Stewart, Shana McCormack
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Meeting Abstract
Endocrinology & Metabolism
Alina German, Shlomo Almashanu, Liat De Vries, Merav Gil, Rana Halloun, Alon Haim, Ori Eyal, Yael Magid, Floris Levi, Dikla Pivko-Levi, Judith Nir, Orit Pinhas-Hamiel, Yardena Tenenbaum-Rakover
HORMONE RESEARCH IN PAEDIATRICS
(2021)