Review
Dermatology
J. Karim Ead, David G. Armstrong
Summary: GM-CSF is a glycoprotein with immunomodulatory properties derived from both hemopoietic and nonhemopoietic sources. In patients with diabetic foot ulcers, GM-CSF activation is impaired, leading to impaired inflammatory response. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore immune balance and promote wound healing.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Xu-Dong Wang, Wei-Jia Yu, Jia-Hui Liu, Jie Du, Kang-Nan Chen, Qin-Qin Hu, Wen-Long Sun, Guo-Qing Ying
Summary: This study investigated a long-acting strategy for modifying rhG-CSF with C15-MAL, which significantly increased its serum half-life and showed potential as a novel drug candidate. The modified C15-rhG-CSF retained its bioactivity and demonstrated improved efficacy compared to other existing treatments.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Immunology
Rebecca A. Sosa, Thomas Mone, Bita V. Naini, Donald B. Kohn, Elaine F. Reed, Kristina Wheeler, Beatriz Campo-Fernandez, Alejandra Davila, Donald J. Chaffin, Joseph DiNorcia, Fady M. Kaldas, Aaron Cohen, Erik L. Lum, Jeffrey L. Veale, Neil M. Kogut
Summary: Solid organ transplantation is the therapy of choice for end-stage organ failure. However, recipients are prone to infections and cancer due to lifelong immunosuppression. The study explores the use of hematopoietic stem cells to induce tolerance in deceased donor kidney recipients, while addressing the concern of immune cell trafficking into the liver.
Article
Oncology
Angelo Borsarelli Carvalho de Brito, Rachel P. Riechelmann, Victor Hugo Fonseca de Jesus
Summary: This study examined the impact of primary prophylaxis (PP) with granulocyte colony-stimulating factor (G-CSF) on the frequency of neutropenia and survival outcomes in patients with metastatic pancreatic adenocarcinoma (MPA) treated with FOLFIRINOX. The results showed that although the frequency of grade 3/4 neutropenia decreased, the risk of febrile neutropenia (FN) was low in the FOLFIRINOX treatment group without G-CSF, and it was not justified for routine use. However, further studies are needed to assess the potential role of G-CSF in improving survival in MPA patients treated with FOLFIRINOX.
Article
Biotechnology & Applied Microbiology
Rui Chen, Yujie Li, Yangyang Zhuang, Yiming Zhang, Hailong Wu, Tao Lin, Shixuan Chen
Summary: This study combines GM-CSF and 3D nanofiber scaffolds to promote tissue regeneration. Through subcutaneous implantation in humanized mice, it was found that GM-CSF could accelerate cell migration and cytokine release, and ultimately enhance tissue regeneration. Therefore, GM-CSF loaded 3D nanofiber scaffolds have potential applications in tissue regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Oncology
Eva-Maria Klein, Sandra Sauer, Sabrina Klein, Diana Tichy, Axel Benner, Uta Bertsch, Juliane Brandt, Christoph Kimmich, Hartmut Goldschmidt, Carsten Muller-Tidow, Karin Jordan, Nicola Giesen
Summary: This study compared antibiotic prophylaxis with G-CSF support as anti-infective strategies in patients with multiple myeloma undergoing HDT/ASCT, showing that G-CSF support is associated with a shorter duration of hospitalization and a lower rate of emerging multidrug resistant bacteria.
Article
Dermatology
K. Wolk, T. -C. Brembach, D. Simaite, E. Bartnik, S. Cucinotta, A. Pokrywka, M. L. Irmer, J. Triebus, E. Witte-Haendel, G. Salinas, T. Leeuw, H. -D. Volk, K. Ghoreschi, R. Sabat
Summary: The expression of G-CSF is high in HS skin, especially in inflamed nodules and abscesses. IL-1 and IL-17 induce G-CSF production, and G-CSF blood levels correlate with the severity of HS.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Orthopedics
Adam W. Anz, Johnny Torres, Hillary A. Plummer, Caroline Siew-Yoke Jee, Travis J. Dekker, Kevin B. Johnson, Khay-Yong Saw
Summary: The study demonstrated the pluripotency of peripheral blood stem cells and their safe harvesting/storage using filgrastim, apheresis, clean-room processing, and cryopreservation. These cells can be stored for 2 years and shipped without loss of viability.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Review
Clinical Neurology
Mahsa Vafaei Mastanabad, Aref Nooraei, Mahgol Sadat Hassan Zadeh Tabatabaei, Amir Akbari Fakhrabadi, Faria Jafarzadeh
Summary: This article introduces the basics of amyotrophic lateral sclerosis (ALS) and G-CSF, and comprehensively reviews the applications of G-CSF in clinical and pre-clinical studies, emphasizing the significant efficacy in pre-clinical studies and the failure to replicate the results in clinical studies.
ACTA NEUROLOGICA BELGICA
(2023)
Review
Medicine, General & Internal
Georgios Konstantis, Georgia Tsaousi, Chryssa Pourzitaki, Elisavet Kitsikidou, Dimitrios E. Magouliotis, Sebastian Wiener, Amos Cornelius Zeller, Katharina Willuweit, Hartmut H. Schmidt, Jassin Rashidi-Alavijeh
Summary: G-CSF has a positive impact on reducing mortality and improving liver function in patients with ACLF, but conclusive recommendations cannot be made due to heterogeneity in the studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Lin Li, Jin Yin, Yun Li, Chunyan Wang, Xia Mao, Jia Wei, Yang Cao, Na Wang, Li Lin, Jinhuan Xu, Yicheng Zhang
Summary: This study compared pegylated granulocyte colony-stimulating factor (peg-G-CSF) with non-peg-G-CSF for hematopoietic stem cell mobilization in allogeneic hematopoietic stem cell transplantation. The mobilization with peg-G-CSF resulted in higher numbers of specific cells and a reduced incidence of severe acute graft-versus-host disease after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shao-Yu Tang, Yi-Chin Lee, Chien-Wei Tseng, Po-Hsun Huang, Ko-Lin Kuo, Der-Cherng Tarng
Summary: This study found that G-CSF can improve angiogenic function in patients with peripheral arterial disease (PAD) associated with chronic kidney disease (CKD) through a hypoxia/IL-10 signaling cascade.
Article
Orthopedics
Konstantinos Papadopoulos, Mantana Paisan, Warachaya Sutheesophon, Thana Turajane
Summary: Osteoarthritis often occurs in older individuals with comorbidities, and the low regenerative power of articular cartilage requires potent tissue engineering approaches for chondrogenic differentiation. Current approaches to coax endogenous reparative cells into the joint space have limited success, but a novel treatment involving IA-hG-CSF combined with AAPBSC shows promising advantages in early osteoarthritis treatment.
Article
Oncology
Erin E. Crotty, Stephanie M. C. Smith, Ken Brasel, Fiona Pakiam, Emily J. Girard, Yamicia D. Connor, Frederique Zindy, Andrew J. Mhyre, Martine F. Roussel, James M. Olson
Summary: The study showed that targeting TAMs and microglia with CSF-1R inhibitors did not significantly impact local and spinal cord recurrences or survival rates in medulloblastoma models. The presence of tumor-infiltrating lymphocytes did not vary significantly between treatment groups, and tumor aggressiveness remained unchanged.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Medicine, General & Internal
Slawomir Lewicki, Monika Lesniak, Agnieszka Sobolewska-Ruta, Aneta Lewicka, Marta Grodzik, Eugeniusz K. Machaj, Marek Saracyn, Jacek Z. Kubiak, Zygmunt Pojda
Summary: Encapsulation of cytokines in liposomes is an efficient method to deliver cytokines to cells at working concentrations without affecting cell morphology or proliferation. This method has great potential and important applications in tissue regeneration and other fields.
ARCHIVES OF MEDICAL SCIENCE
(2022)
