Article
Cell & Tissue Engineering
Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei, Yanqiu Yu
Summary: The study found that conditioned medium (CM) obtained from placental cells or tissue contained proangiogenic factors that promoted HUVEC angiogenesis in vitro. Placental cells from early pregnancy played a more significant role in promoting HUVEC angiogenesis, and CM collected at 24h or 48h had the best effect. Among all time points, CM collected from sub-cultured placental tissue at 7 days had the best effect.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Solen Novello, Sylvie Tricot-Doleux, Agnes Novella, Pascal Pellen-Mussi, Sylvie Jeanne
Summary: This study evaluated the influence of periodontal ligament stem cell-derived conditioned medium (CM) on osteoblasts and its potential as a therapeutic tool for periodontal regeneration. The findings showed that PDLSC-CM enhanced osteoblast proliferation and increased the expression of some osteoblastic differentiation markers.
Review
Medicine, Research & Experimental
Hongbing Lin, Huishan Chen, Xuetao Zhao, Zhen Chen, Peipei Zhang, Yue Tian, Yawei Wang, Tong Ding, Lijing Wang, Yuqin Shen
Summary: Periodontitis is a chronic inflammatory disease that poses a challenge for complete regeneration in clinics. Mesenchymal stem cells (MSCs) show potential for regenerating periodontal tissue, but their direct use faces drawbacks such as low survival rate and host immune reactions. MSC culture conditioned medium (CM) offers a promising indirect treatment approach with the potential to overcome these challenges for periodontal tissue regeneration.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Physiology
Yixiu Zhong, Youfan Zhang, Aijiao Yu, Zhiwen Zhang, Zhenjun Deng, Kaifen Xiong, Qi Wang, Jianglin Zhang
Summary: This review mainly discusses the roles of mesenchymal stem cell-derived exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Liming Li, Jiafu Mu, Yu Zhang, Chenyang Zhang, Teng Ma, Lu Chen, Tianchen Huang, Jiahe Wu, Jian Cao, Shiqing Feng, Youzhi Cai, Min Han, Jianqing Gao
Summary: This study found that exosomes derived from hypoxic preconditioned human umbilical vein endothelial cells can stimulate angiogenic MSCs, showing great potential in the treatment of traumatic spinal cord injury.
Article
Biochemistry & Molecular Biology
Pouria Hajmomeni, Sajjad Sisakhtnezhad, Ali Bidmeshkipour
Summary: Breast cancer, the most prevalent cancer in females, can be affected by mesenchymal stem cells (MSCs) and their paracrine effects. Thymoquinone (TQ) has various properties and affects the self-renewal and immunomodulatory properties of MSCs. The study examined the effect of TQ-treated MSC conditioned medium on the characteristics of breast cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Medicine, Research & Experimental
Daphne Pinheiro, Isabelle Dias, Thiago Freire, Alessandra Alves Thole, Ana Carolina Stumbo, Erika Afonso Costa Cortez, Lais de Carvalho, Simone Nunes de Carvalho
Summary: The study demonstrated that MSC CM treatment reduced hepatic enzyme levels and collagen deposition in the liver, while also decreasing the profibrotic IL-17A and increasing IL-6 and IL-4. This suggests that MSC CM treatment has therapeutic potential in cholestatic liver fibrosis, promoting matrix remodeling and cytokine profile favorable for liver regeneration.
Article
Cell Biology
Bo Sun, Xianhui Meng, Yumin Li, Yanlong Li, Rui Liu, Zhongdang Xiao
Summary: In this study, we demonstrated that conditioning medium derived from human cord blood mesenchymal stem cells (CBMSC-CM) improved immune response efficiency and reduced cellular senescence in aged mice. CBMSC-CM administration resulted in a decrease in NK and regulatory T-cell populations in peripheral blood, an increase in naive T-cell number, and restoration of the ratio of naive to memory T-cells in CD4(+) T-cell population. Additionally, CBMSC-CM treatment reduced the number of senescent T-cells in kidney tissues and attenuated hydrogen peroxide triggered T-cell response and oxidative stress induced cellular senescence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Yu-Guo Yuan, Jia-Lin Wang, Ya-Xin Zhang, Ling Li, Abu Musa Md Talimur Reza, Sangiliyandi Gurunathan
Summary: This review discusses the potential function of mesenchymal stem cell-derived exosomes (MSCs-EXOs) in various diseases including neurological, cancer, autoimmune, and inflammatory diseases. It also highlights the potential use of MSCs-EXOs in treating COVID-19 inflammatory disease. Additionally, it provides an overview of exosome biogenesis, factors regulating it, strategies, and challenges of using MSCs-EXOs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Jingwen Zhuang, Ruiyue Hang, Ruoyue Sun, Yanshu Ding, Xiaohong Yao, Ruiqiang Hang, Hui Sun, Long Bai
Summary: Exosomes secreted by bone marrow mesenchymal stem cells have multifaceted effects on osseointegration and hold great promise as a safe, efficient, and ethically unrestricted therapy.
FRONTIERS IN CHEMISTRY
(2022)
Review
Cell Biology
Trinidad Montero-Vilchez, Alvaro Sierra-Sanchez, Manuel Sanchez-Diaz, Maria Isabel Quinones-Vico, Raquel Sanabria-de-la-Torre, Antonio Martinez-Lopez, Salvador Arias-Santiago
Summary: Mesenchymal stromal cell-conditioned medium (MSC-CM) shows promising potential in treating skin conditions by improving wound healing, hair restoration, skin rejuvenation, and some inflammatory skin diseases. Further research is needed to confirm its safety, effectiveness, and to standardize the manufacturing process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Benson Koh, Farynna Hana Ab Rahman, Najwa Amira Matlan, Manissha Rajan, Aimi Yasmin Musta'ain, Mohamad Ridhwan Mohd Jeffry Lee, Roszalina Ramli, Siti Salmiah Mohd Yunus, Ruszymah Binti Hj Idrus, Muhammad Dain Yazid
Summary: DPSCs conditioned medium has the potential to induce odontoblastic differentiation in WJMSCs, but further research is needed to understand its stimulating effects and signaling pathways.
BIOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yoon-Young Go, Chan-Mi Lee, Sung-Won Chae, Jae-Jun Song
Summary: The study demonstrated the potential of trophoblast-derived conditioned medium (TB-CM) in promoting osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) and inhibiting adipogenesis. By activating biological processes such as signaling pathways, the trophoblast-derived secretomes show promise for clinical interventions in bone regeneration and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mahesh Ramalingam, Sujeong Jang, Han-Seong Jeong
Summary: The study assessed the neuroregenerative effects of stem cell-conditioned medium in a Parkinson's disease-related cell model, and found that this treatment method had significant protective effects against cell toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ragda Saleem, Samih Mohamed-Ahmed, Rammah Elnour, Ellen Berggreen, Kamal Mustafa, Niyaz Al-Sharabi
Summary: The study identified antioxidant proteins in MSC-CM that can enhance osteogenic differentiation of hBMSC exposed to oxidative stress induced by H2O2. MSC-CM restored H2O2-induced damage to hBMSC by increasing antioxidant enzyme production and anti-apoptotic gene expression, reducing ROS production and cellular apoptosis. Additionally, MSC-CM modulated mRNA expression levels of osteogenesis-related genes and increased collagen type I protein secretion, alkaline phosphatase activity, and in vitro mineralization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)